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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Investigation of the aerodynamic characteristics of an aerofoil shaped fuselage UAV model显示文摘 | ALAM J MAMUN M ALI T A | 2014 | Procedia Engineering2014，90，： | 1 |
| 3 | Does hypertensive disorder of pregnancy predict offspring blood pressure at 21 years?Evidence from a birth cohort study显示文摘 | Mamun AA Kinarivala MK O'Callaghan M | 2012 | J Hum Hypertens2012，26，5： | 1 |
| 4 | Oral misoprostol forpre- venting postpartum haemorrhage in home births in rural Bangla- desh: howeffective is it显示文摘 | Nasreen H E Nahar S Al Mamun M | 2011 | Global health action2011，4，： | 1 |
| 5 | Low-frequency drift wave instabilities in a magnetized dust plasma 显示文摘 | Salahuddin M Mamun A A | 1999 | Astrophys Space Sci1999，262，： | 1 |
| 6 | Spectro- photometric determination of lead in industrial, environ- mental, biological and soil samples using 2,5-dimercapto- 1,3,4-thiadiazole显示文摘 | Jamaluddin Ahmed M Mosaddequc-A1 Mamun | 2001 | Talanta2001，55，： | 1 |
| 7 | EOQ models for a coordinated two-level international supply chain considering imperfect items and environmental im- pact 显示文摘 | Wahab M I M Mamun S M H Ongkunaruk P | 2011 | International Journal of Production Economics2011，134，1： | 1 |
| 8 | Integrated pest management in tea: prospects and future strategies in Bangladesh 显示文摘 | Mamun M S A Ahmed M | 2011 | The Journal of Plant Protection Sciences2011，3，2： | 1 |
| 9 | Associations of excess weight gain during pregnancy with long-term maternal overweight and obesity:evidence from 21 y postpartum follow-up显示文摘 | MAMUN A A KINARIVALA M O'CALLAGHAN M J | 2010 | Am J Clin Nutr2010，91，： | 1 |
| 10 | EOQ models for a coordinated two-level international supply chain considering imperfect items and environmental impact显示文摘 | WahabMI M Mamun SMH Ongkunaruk P | 2011 | Int J of Production Economics2011，134，1： | 1 |
| 11 | Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age:evidence from a birth cohort study显示文摘 | Mamun AA O' Callaghan M Callaway L | 2009 | Circulation2009，119，13： | 1 |
| 12 | The Effect of Heat Treatments and Coatings on theOutgassing Rate of Stainless Steel Chambers 显示文摘 | Mamun M A A Elmustafa A A Stutzman M L | 2014 | Journalof Vacuum Science & Technology A Vacuum Surfaces& Films2014，32，2： | 1 |
| 13 | A privacy-preserving efficient RFID authentication protocol from SLPN assumption显示文摘 | MAMUN M S I and MIYAJI A | 2015 | International Journal of Computational Science and Engineering2015，10，3： | 1 |
| 14 | Spectrophotometric Determination of Lead in Industrial,Environmental, Biological and Soil Samples Using 2,5-dimercapto-1-3,4-thiadiazole显示文摘 | Jamaluddin M Ahmed Mosaddeque-Al Mamun | 2001 | Talanta2001，55，1： | 1 |
| 15 | Association between weight gain during pregnancy and postpartum weight retention and obesity:a bias-adjusted metaanalysis显示文摘 | MANNAN M DOI S A MAMUN A A | 2013 | Nutr Rev2013，71，： | 1 |
| 16 | Effect of drying methods on the functional properties of soy hull pectin显示文摘 | Mamun A M | 2005 | Carbohydrate Polymers2005，61，3： | 1 |
| 17 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 18 | EOQ models for a coordinated two-level international supply chain considering imper-fect items and environmental impact显示文摘 | Wahab M Mamun S Ongkunaruk P | 2011 | International Journal of Production Economics2011，134，1： | 1 |
| 19 | EOQ models for a coordinated two-level international supply chain considering imperfect items and environmental impact显示文摘 | Wahab M Mamun S Ongkunaruk P | 2011 | Int J of Production Economics2011，134，1： | 1 |
| 20 | Sulphate resistance of fibre reinforced cement-based foams 显示文摘 | MAMUN M BINDIGANAVILE V | 2011 | Construction and Building Materials2011，25，8： | 1 |
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