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| 1 | Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome显示文摘Disordered signalling between the brain and the gut are generally accepted to underlie the functional bowel disorder, irritable bowel syndrome(IBS). However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. This common gastrointestinal disorder is characterised by alterations in bowel habit such as diarrhoea and/or constipation, bloating and abdominal pain, and symptom exacerbation has been linked with periods of stress, both psychosocial and infection-related. Indeed, a high level of comorbidity exists between IBS and stress-related mood disorders such as anxiety and depression. Moreover, studies have observed alterations in autonomic output and neuro-endocrine signalling in IBS patients. Accumulating evidence indicates that a maladaptive stress response, probably mediated by the stress hormone, corticotropin-releasing factor contributes to the initiation, persistence and severity of symptom flares.Other risk factors for developing IBS include a positive family history, childhood trauma, dietary factors and prior gastrointestinal infection. An emerging role has been attributed to the importance of immune factors in the pathophysiology of IBS with evidence of altered cytokine profiles and increased levels of mucosal immune cells. These factors have also been shown to have direct effects on neural signalling. This review discusses how pathological changes in neural, immune and endocrine pathways, and communication between these systems, contribute to symptom flares in IBS. | Maria M Buckley Siobhain M O'Mahony Dervla O'Malley | 2014 | World Journal of Gastroenterology2014，20，27： | 24 |
| 2 | High gain GaAs potoconductive semiconductor switches for impulse sources显示文摘 | LOUBREIL G M ZUTAVERN F J O'MALLEY M W | 1994 | SPIE1994，2343，： | 2 |
| 3 | Patients'priorities for medical care显示文摘 | Fletcher R H O'Malley M S Earp J A | 1983 | Medical Care1983，21，2： | 1 |
| 4 | Inheritance, gene ex- pression, and lignin characterization in a mutant Pine deficient in cinnamyl alcohol dehydrogenase显示文摘 | John M David M Malley O | 1997 | Plant Biology1997，94，： | 1 |
| 5 | Optimal allocation of embedded generation on distribution networks显示文摘 | Keane A O'Malley M | 2005 | IEEE Trans on Power Systems2005，20，3： | 1 |
| 6 | A study of principal component analysis applied to spatially distributed wind power显示文摘 | BURKE D J O'MALLEY M J | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 7 | Listening coprehension strategies in secondlanguage acquisition 显示文摘 | | 1989 | Applied Linguistics1989，11，： | 1 |
| 8 | Augmented Hopfield Network for Unit Commitment and Economic Dispatch显示文摘 | Walsh M P O'Malley M J | 1997 | IEEE Trans on Power Systems1997，12，4： | 1 |
| 9 | Frequency control in competitive electricity market dispatch显示文摘 | Ronan Doherty Gillian Lalor Malley M O | 2005 | IEEE Trans on Power Systems2005，20，3： | 1 |
| 10 | Listening comprehension strategies in second language acquisition 显示文摘 | O'Malley J M Chamot A U & Kupper L | 1989 | Applied Linguistics1989，，10： | 1 |
| 11 | Design of a Haptic Arm Exoskeleton for Training and Rehabilitation显示文摘 | A Gupta M K O'Malley | 2006 | IEEE/ASME Transactions on Mechatronics2006，11，3： | 1 |
| 12 | Positional cloning of the mouse obese gene and its human homologue显示文摘 | Zhang Y Proenca P Mallei M | 1994 | Nature1994，372，： | 1 |
| 13 | MRI measurements of the cervical spine and their correlation to Parlor's ratio 显示文摘 | Prasad SS O'Malley M Caplan M | 2003 | Spine2003，28，12： | 1 |
| 14 | Controllers of Ziegler- Nichols type for unstable process with time delay显示文摘 | De Paor A M O'Malley M | 1989 | International Journal of Control1989，49，4： | 1 |
| 15 | A steady-state voltage stability analysis of power systems with high penetrations of wind显示文摘 | Vittal E O'Malley M Keane A | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 16 | Weight-reducing effects of the plasma protein encoded by the obese gene 显示文摘 | Halaas JL Gajiwala KS Mallei M | 1995 | Science1995，269，： | 1 |
| 17 | MR urography显示文摘 | HUSSAIN S O′MALLEY M JARA H | 1997 | Magn Reson Imaging Clin N Aam1997，5，1： | 1 |
| 18 | Pancreatic phase versus portal vein phase helical CT of the pancreas:optimal temporal window for evaluation of pancreatic adenocarcinoma显示文摘 | Boland GW O'Malley ME Saez M | 1999 | AJR1999，172，3： | 1 |
| 19 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123显示文摘 | Stephen L Hempel Garry R Buettner Yunxia Q O’Malley Duane A Wessels Dawn M Flaherty | 1999 | Free Radical Biology and Medicine1999，，1： | 1 |
| 20 | Release of platelet Constituents by monosodiumurate crystals显示文摘 | Kozinf O Malley M | 1997 | J Clin Invest1997，60，6： | 1 |
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