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| 1 | Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7显示文摘AIM To present the incidence of heterotopic ossification after the use of recombinant human bone morphogenetic protein-7(rhB MP-7) for the treatment of nonunions.METHODS Bone morphogenetic proteins(BMPs) promote bone formation by auto-induction. Recombinant human BMP-7 in combination with bone grafts was used in 84 patients for the treatment of long bone nonunions. All patients were evaluated radiographicaly for the development of heterotopic ossification during the standard assessment for the nonunion healing. In all patients(80.9%) with radiographic signs of heterotopic ossification, a CT scan was performed. Nonunion site palpation and ROM evaluation of the adjacent jointswere also carried out. Factors related to the patient(age, gender), the nonunion(location, size, chronicity, number of previous procedures, infection, surrounding tissues condition) and the surgical procedure(graft and fixation type, amount of rhB MP-7) were correlated with the development of heterotopic ossification and statistical analysis with Pearsons χ~2 test was performed.RESULTS Eighty point nine percent of the nonunions treated with rh BMP-7, healed with no need for further procedures. Heterotopic bone formation occurred in 15 of 84 patients(17.8%) and it was apparent in the routine radiologi-cal evaluation of the nonunion site, in a mean time of 5.5 mo after the rh BMP-7 application(range 3-12). The heterotopic ossification was located at the femur in 8 cases, at the tibia in 6, and at the humerus in οne patient. In 4 patients a palpable mass was present and only in one patient, with a para-articular knee nonunion treated with rhB MP-7, the size of heterotopic ossification affected the knee range of motion. All the patients with heterotopic ossification were male. Statistical analysis proved that patient's gender was the only important factor for the development of heterotopic ossification(P = 0.007). CONCLUSION Heterotopic ossification after the use of rh BMP-7 in nonunions was common but it did not compromise the final clinical outcome in most cases, and affected only male patients. | Marianthi Papanagiotou Zoe H Dailiana Theophilos Karachalios Sokratis Varitimidis Michael Hantes Georgios Dimakopoulos Marianna Vlychou Konstantinos N Malizos | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 2 | Lectin - like oxidized low density lipoprotein receptor 1 ( LOX - 1 ) expression in human articu- lar chondrocytes显示文摘 | Simopoulou T Malizos KN Tsezou A | 2007 | Clin Exp Rheumato12007，25，： | 1 |
| 3 | Osteone-crosis of the femoral head:Etiology,imaging and treatment显示文摘 | Malizos KN Karantanas AH Varitimidis SE | | 0，，01： | 1 |
| 4 | Bone morphogenetic protein-2-induced Wnt/-catenin signaling pathway activation through enhanced low-density- lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes 显示文摘 | Papathanasiou I Malizos KN Tsezou A | 2012 | Arthritis Res Ther2012，14，2： | 1 |
| 5 | Treatment of avascular necrosis of the femoral head with vascularized fibular transplant显示文摘 | Soucacos PN Beris AE Malizos K | 2001 | Clin Orthop2001，386，： | 1 |
| 6 | Inte- grative microRNA and proteomie approaches identify novel osteoar- thritis genes and their collaborative metabolic and inflammatory networks显示文摘 | ILIOPOULOS D MALIZOS K N OIKONOMOU P | 2008 | PLoS One2008，3，11： | 1 |
| 7 | Complications in limb - lengthening procedures : a review of 49 cases 显示文摘 | Hantes ME Malizos KN Xenakis TA | 2001 | Am J Orthop2001，6，： | 1 |
| 8 | Central role of SREBP -2 in the pathogenesis of osteoarthritis 显示文摘 | Kostopoulou F Gkretsi V Malizos KN | 2012 | PloS One2012，7，35： | 1 |
| 9 | MR imaging findings in transient osteoporosis of the hip显示文摘 | MALIZOS K N ZIBIS A H DAILIANA Z | 2004 | Eur J Radiol2004，50，3： | 1 |
| 10 | Relapsed clubfoot correction with soft-tissue release and selective application of Ilizarov technique显示文摘 | Malizos KN Gougoulias NE Dailiana ZH | 2008 | Strategies Trauma Limb Reconstr2008，3，3： | 1 |
| 11 | Repair and tissue engineering techniques for articular cartilage显示文摘 | Makris EA Gomoll AH Malizos KN | 2015 | Nat Rev Rheumatol2015，11，1： | 1 |
| 12 | Longstanding nonunions of scaphoid fractures with bone loss successful reconstruction with vascularized bone grafts 显示文摘 | Malizos KN Dailiana ZH Kirou M | 2001 | J Hand Surg [ Br]2001，26，4： | 1 |
| 13 | Osteonecrosis of the femoral head:Etiology,imaging and treatment显示文摘 | Malizos KN Karantanas AH Varitimidis SE | | 0，，01： | 1 |
| 14 | Treatment of avascular necrosis of the femoral head with vascularized fibular transplant显示文摘 | Soucacos PN Beris AE Malizos K | | 0，，386： | 1 |
| 15 | Treatment of avaseular necrosis of the femoral head with vascularized fibular transplant显示文摘 | Soucaeos PN Beris AE Malizos K | 2001 | Clin Orthop Relate Res2001，386，： | 1 |
| 16 | Integrative microRNA and proteomic approaches identify novel osteo- arthritis genes and their collaborative metabolic and inflam- matory networks显示文摘 | Iliopoulos D Malizos KN Oikonomou P | 2008 | PLoS One2008，3，： | 1 |
| 17 | Lowintensity pulsed ultrasound for bone healing: an overview显示文摘 | Malizos KN Hantes ME Protopappas V | 2006 | Injury2006，37，1： | 1 |
| 18 | The role of MR imaging in scaphoid disorders显示文摘 | Karantanas A Dailiana Z Malizos K | 2007 | Eur Radiol2007，17，11： | 1 |
| 19 | Low-intensi- ty pulsed ultrasound for bone healing: an overview显示文摘 | Malizos KN Hantes ME Protopappas V | 2006 | Inju- ry2006，37，1： | 1 |
| 20 | 1,25-Dihydrox- yvitamin D3 and extracellular inorganic phosphate activate mito- gen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in os- teoarthritic chondrocytes显示文摘 | Orfanidou T Malizos KN Varitimidis S | 2012 | Exp Biol Med2012，237，24： | 1 |
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