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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 4 | Design of robust controllers for time-delay systems显示文摘 | Mahmoud M S Al-Muthairi N F | 1994 | IEEE Trans Automat Contr1994，39，： | 1 |
| 5 | The non- covalent decoration of self-assembling protein fibers 显示文摘 | Mahmoud Z N Grundy D J Channon K J | 2010 | Biomaterials2010，31，29： | 1 |
| 6 | Simu- lation, Integration, and Economic Analysis of Gas-to-Liquid Processes显示文摘 | Bao Buping El-Halwagi Mahmoud N Elbashir Nimir O | 2010 | Fuel Processing Technology2010，91，： | 1 |
| 7 | Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis 显示文摘 | MAHMOUD N N CAROTHERS A M GRUNBERG- ER D | 2000 | Carcinogenesis2000，21，： | 1 |
| 8 | Design of robust controller for time-delay systems显示文摘 | Mahmoud M S Al-Muthairi N F | 1994 | IEEE Trans on Automatic Control1994，39，8： | 1 |
| 9 | Least sum of squared errors (LSSE) channel estimation显示文摘 | S N Crozier D D Falconer S A Mahmoud | 1991 | Radar and Signal Processing IEE Proceedings F1991，138，4： | 1 |
| 10 | On autonomous and nonautonomous modified hyperchaotic complex la systems显示文摘 | Mahmoud G M Ahmed M E Sabor N | 2011 | I J Bifurcation and Chaos2011，21，： | 1 |
| 11 | Longer time inter val between completion of neoadjuvant ehemoradiation and sur- gical resection does not improve downstaging of rectal carcino- ma显示文摘 | Stein D E Mahmoud N N Anne P R | 2003 | Dis Colon Rectum2003，46，： | 1 |
| 12 | Why do African A- mericans get more colon cancer them native Africans? 显示文摘 | O'keefe SJ Chung D Mahmoud N | 2007 | J Nutr2007，137，1： | 1 |
| 13 | Effect of magnesium sulfate therapy on patients with aneurismal subarachnoid hemorrhage using serum S100B protein as a prognostic marker显示文摘 | Tamer H Mahmoud N | 2012 | Neurosurg Rev2012，35，4： | 1 |
| 14 | Heavy metal pollution assessment in relation to sediment properties in the coast- al sediments of the southern Caspian Sea显示文摘 | Kazem D B Mahmoud R N Farzaneh S | 2015 | Marine Pollution Bulletin2015，92，12： | 1 |
| 15 | The current management of rectal cancer显示文摘 | Ross HM Mahmoud N Fry RD | 2005 | Curr Probl Surg2005，42，2： | 1 |
| 16 | Altered immunoglobulin isotype profile and anti-immatrue worm surface immunoglobulins in mice harboring a praziquantel-resistant Schistoso ma mansonii solate显示文摘 | Hanallah S EL-Lakkany N Mahmoud S | 2003 | APMIS2003，111，12： | 1 |
| 17 | Coastal sewage discharge and its impact on fish with reference to antibiotic resistant enteric bacteria and enteric pathogens as bioindicators of pollution显示文摘 | Al-Bahry S N Mahmoud I Y Al-Belushi K I A | | 0，，： | 1 |
| 18 | The current management of rectal cancer显示文摘 | Ross HM Mahmoud N Fry RD | 2005 | Curr Probl Surg2005，42，： | 1 |
| 19 | Anaerobic sewage treatment in a one-stage UASB reactor and a combined UASB-Digester system 显示文摘 | Mahmoud N Zeeman G Gijzen H | 2004 | Water Research2004，38，9： | 1 |
| 20 | Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis显示文摘 | Mahmoud N N Carothers A M Grunberger D | 2000 | Carcinogenesis2000，21，5： | 1 |
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