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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Frequency and predictive factors of malignancy in residual thyroid tissue and cervical lymph nodes after partial thyroidectomy for thyroid cancer显示文摘 | Alzahrani AS AI Mahdi M Chaudhary MA | 2002 | Surgery2002，131，4： | 1 |
| 3 | Immune stimulation improves endocrine and neural fetal outcomes in a model of maternofetalthyrotoxicosis显示文摘 | Ahmed RG Abdel-Latif M Mahdi EA | 2015 | Int Immunopharmacol2015，29，2： | 1 |
| 4 | Screening analysis of beer ageing using near infrared spectroscopy and the successive projections algorithm for variable selection显示文摘 | MAHDI G V SEYED S M MARIA L R M | 2012 | Talanta2012，89，1： | 1 |
| 5 | Blockade of vascular endothelial growth factor receptor Ⅰ(VEGF R Ⅰ),but not VEGF-R Ⅱ,suppresses joint destruction in the K/BxN model of rheumatoid arthritis显示文摘 | de Bandt M Ben Mahdi MH Ollivier V | 2003 | J Immunol2003，171，9： | 1 |
| 6 | Decision Support SystemForselecting the Proper Project Delivery Method Usinganalytical Hierarchy Process(AHP)显示文摘 | MAHDI I M ALRESHAID K | 2005 | InternationalJournal of Project Management2005，，23： | 1 |
| 7 | Laboratory aspects of asymptomatic bacteriuria after operation 显示文摘 | Mohammad M Mahdy ZA Omar J | 2002 | Southeast Asian J Trop Med Public Health2002，33，3： | 1 |
| 8 | Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis显示文摘 | MAHDY A M LOWES D A GALLEY H F | 2006 | Clin Vaccine Immunol2006，13，4： | 1 |
| 9 | Secondary outcomes of a pilot randomized trial of azithromycin treatment for asthma显示文摘 | Hahn D L Plane M B Mahdi O S | 2006 | PLOS Clin Trials2006，1，： | 1 |
| 10 | Comparative study between bo- tulinum toxin injection and partial division of pnborectalis for treating anismus显示文摘 | Farid M Youssef T Mahdy T | 2009 | Int J Colorectal Dis2009，24，3： | 1 |
| 11 | Solving a dynamic virtual cell formation problem by linear programming embedded particle swarm optimization algorithm 显示文摘 | Hassan R Reza M Mahdi Z | 2011 | Applied Soft Computing2011，，11： | 1 |
| 12 | Thyroid surgery: Use of the LigaSure vessel sealing system versus conventional knot tying显示文摘 | Youssef T Mahdy T Farid M | 2008 | Int J Surg2008，6，4： | 1 |
| 13 | Effects of preparation conditions on the monodispersity of albumin microspheres 显示文摘 | Ibrahim E - S Safwat S | 1998 | Journal of Microencapsulation1998，15，5： | 1 |
| 14 | Decomposition of 14C-fenitrothion under the influence of UV and sunlight under tropical and subtropical conditions显示文摘 | Zayed S M Mahdy F | 2008 | Cheraosphere2008，70，： | 1 |
| 15 | Methyltrioxorhenium-catalyzed epoxidating in ionic liquids 显示文摘 | GREGORY S OWENS MAHDI M | 2000 | Chem Commun2000，13，： | 1 |
| 16 | Forecasting output umng oil price:a cascaded artificial neural network approach 显示文摘 | M Fareoq N Mahdi | 2006 | Journal of Economics and Business2006，58，2： | 1 |
| 17 | Evaluating response modification factors of concentrically braced steel frames 显示文摘 | Mussa M Mahdi Z | 2010 | Journal of Constructional Steel Research2010，66，10： | 1 |
| 18 | Optimal fixed gain linear proces-sing for amplify-and-forward multichannel relaying 显示文摘 | Dong M Mahdi H Liang B | 2012 | IEEETrans on Signal Processing <2012，60，11： | 1 |
| 19 | Crushing response of composite corrugated tubes to quasi-static axial loading显示文摘 | Elgalai A M Mahdi E Hamouda A M S | 2004 | Composite Structures2004，66，14： | 1 |
| 20 | Solving flexible job shop sched- uling with multi objective approach显示文摘 | Arash M Kamyar S Mahdi H | 2010 | International Journal of Industrial Engineering & Production Research2010，21，4： | 1 |
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