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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Carcinogenic nitroso compounds显示文摘 | Magee P N Barnes J M | 1967 | Adv Cancer Res1967，10，： | 2 |
| 3 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 4 | Assessment of tobacco-specific N-nitrosamines in tobacco products显示文摘 | MAGEE P N MONTESANO R PREUSSMAN R | 1976 | ACS Monogr1976，173，： | 1 |
| 5 | The experimental basis for the role of nitroso compounds in human cancer显示文摘 | MAGEE P N | 1989 | Cancer Survey1989，8，2： | 1 |
| 6 | Haemodynamic monitoring with pulse-induced countour cardiac output (PiCCO) in critical care 显示文摘 | Cottis R Magee N Higgins D J | 2003 | Intensive Crit Care Nurs2003，19，5： | 1 |
| 7 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 8 | Structuring parallel and distributed programs 显示文摘 | Magee J Dulay N Kramer J | 1993 | Software Engineering Journal1993，8，2： | 1 |
| 9 | Structuring parallel and distributed programs显示文摘 | Magee J Dulay N Kramer J | 1993 | Software Engineering Journal1993，8，2： | 1 |
| 10 | The urban heat island effect at Fairbanks, Alaska显示文摘 | Magee N Curtis J ld Wendler G | 1999 | Theoretical and Applied Climatology1999，64，： | 1 |
| 11 | The inhibition of malignant cell growth by ketone bodies显示文摘 | MAGEE B A POTEZNY N ROFE A M | 1979 | Aust J Exp Bioi Med Sci1979，57，： | 1 |
| 12 | Identification of two novel mutations in karation 13 as the cause of white sponge naevtts显示文摘 | Rugg E Magee G Wilson N | 1999 | Oral Dis1999，5，4： | 1 |
| 13 | Haemodynamic monitoring with pulse- induced contour cardiac output (PiCCO) in critical care显示文摘 | CottisR Magee N Higgins DJ | 2003 | Intensive Crit Care Nurs Oct2003，19，5： | 1 |
| 14 | Nature显示文摘 | Earlel M J Esperanca J M Gilea M A Canongia-Lopes J N Rebelo L P N Magee J W Seddon K R Widegren J A | 2006 | 439 : 832006，439，： | 1 |
| 15 | Identification of two novel muta- tions in keratin 13 as the cause of white sponge naevus 显示文摘 | Rugg E Magee G Wilson N | 1999 | Oral Dis1999，5，4： | 1 |
| 16 | A First Look at Health Cyber Map Medical Semantic Subject Search Engine 显示文摘 | Boulos Maged N Kamel | 2004 | Technology & Health Care2004，，11： | 1 |
| 17 | The production of malignant primary hepatictumours in the rat by feeding dimethylnitrosamine显示文摘 | MAGEE P N BAMES J M | 1956 | Br J Cancer1956，，1： | 1 |
| 18 | Myostatin short in- terfering hairpin RNA gene transfer increases skeletal muscle mass显示文摘 | Magee T R Artaza J N Ferrini M G | 2006 | J GeneMed2006，8，： | 1 |
| 19 | Carcinogenic nitroso compounds 显示文摘 | MAGEE P N BARNES J M | 1967 | Adv Cancer Res1967，，10： | 1 |
| 20 | Surgery {or the manage-ment of ovarian endometriomas:from the physiopathology to the pre-peri- and postoperative treatment显示文摘 | Bourdel N Roman H Mage G | 2011 | Gynecol Obstet Ferti12011，39，12： | 1 |
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