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1Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation.Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu 2015World Journal of Gastroenterology2015,21,19:37
2生物质燃烧颗粒物有机示踪化合物的测定和应用显示文摘使用气相色谱-质谱法对2002年7月-2003年7月的北京市大气粗、细颗粒物样品中的左旋葡聚糖等糖类化合物进行了测定。结果表明,左旋葡聚糖主要存在于细颗粒中,可以作为示踪化合物来研究生物质燃烧现象。生物质燃烧对北京市大气颗粒物有较重要的贡献,对应于12%-40%的PM2.5有机碳和10%-33%的PM10有机碳。北京市在2002年10月和11月受到明显的生物质燃烧的影响,可能由于农田秸杆焚烧和秋季落叶焚烧。2003年5月7日颗粒物样品受到直线距离约为1000 km以外的内蒙古自治区呼伦贝尔市大兴安岭林区森林大火烟雾的影响。生物质燃烧事件具有突发性,可以长距离传输;生物质作为农村生物燃料的使用其燃烧排放具有经常性和持久性的特征。张烃 刘咸德 董树屏 祁辉 Hélène Cachier Magda Claeys 2006岩矿测试2006,25,2:17
3Impact of osteoporosis in dental implants:A systematic review显示文摘AIM: To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects. METHODS: Extensive examination strategies were created to classify studies for this systematic review. MEDLINE(via Pub Med) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeS H words described as follow: 'osteoporosis' or 'osteopenia' or 'estrogen deficiency' AND 'implant' or 'dental implant' or 'osseointegration'. Assessment of clinical and/or histological peri-implant conditions in osteoporosis subjects treated with titanium dental implants. The examination included a combination of the MeS H terms described as follow: 'osteoporosis' or 'osteopenia' or 'estrogen deficiency' AND 'implant' or 'dental implant' or 'osseointegration'.RESULTS: Of 943 potentially eligible articles, 12 were included in the study. A total of 133 subjects with osteoporosis, 73 subjects diagnosed with osteopenia and 708 healthy subjects were assessed in this systematic review. In these subjects were installed 367, 205, 2981 dental implants in osteoporotic, osteopenic and healthy subjects, respectively. The failure rate of dental implant was 10.9% in osteoporotic subjects, 8.29% in osteopenic and 11.43% in healthy ones. Bone-to-implant contact obtained from retrieved implants ranged between 49.96% to 47.84%, for osteoporosis and non-osteoporotic subjects. CONCLUSION: Osteoporotic subjects presented higher rates of implant loss, however, there is a lower evidence to strengthen or refute the hypothesis that osteoporosis may have detrimental effects on bone healing. Consequently, final conclusions regarding the effect of osteoporosis in dental implant therapy cannot be made at this time. There are no randomized clinical trial accessible for evaluation and the retrospectivenature of the evaluated studies shall be taken in account when interpreting this study.Gabriela Giro Leandro Chambrone Abrao Goldstein Jose Augusto Rodrigues Elton Zenóbio Magda Feres Luciene Cristina Figueiredo Alessandra Cassoni Jamil Awad Shibli 2015World Journal of Orthopedics2015,6,2:11
4Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients显示文摘AIM: To evaluate the safety and the efficacy of the ultrasound ciliary plasty(UCP) on the intraocular pressure(IOP) control in glaucomatous eyes without previous glaucoma surgery.METHODS: A retrospective study included patients with primary and secondary glaucoma who underwent UCP in Dar Al Shifa Hospital, Kuwait between January 2017 to June 2018. High-intensity focused ultrasound procedures were performed under peribulbar anesthesia using the 2^(nd) generation probe with 8 s duration of each of the 6 shots. Complete ophthalmologic examinations were scheduled pre-treatment, and at 1 d, 1 wk, 1, 3, 6 and 12 mo posttreatment. Primary outcomes were the IOP reduction and success rates at 12 mo, while the secondary outcomes were the occurrence of vision threatening complications and visual acuity.RESULTS: The records of 62 eyes of 62 patients were analyzed with mean age of 63.8 y(67.7% males). There was statistically significant reduction in the mean IOP from 35.2±8.3 mm Hg before treatment to 20.6±8.7 mm Hg at 12^(th) month(P<0.0005) with a mean percentage IOP reduction of 42.3% with significant reduction in the mean number of antiglaucomatous drugs from 3.2±0.4 before treatment to 2.1±1.02 at 12 mo(P<0.0005). Qualified success was achieved in 77.4% of eyes at 12 mo. No major intra-or posttreatment complications were reported.CONCLUSION: Second-generation UCP prove to be effective in reducing IOP in naive glaucoma patients with lower success rates in cases of neovascular and uveitic glaucomas.Magda A.Torky Yousif A Al Zafiri Sherein M.Hagras Abeer M.Khattab Rania M.Bassiouny Tharwat H.Mokbel 2019International Journal of Ophthalmology(English edition)2019,12,4:9
5小型底栖生物在北海南部湾生态监测中的应用研究显示文摘北海南部湾(the Southern Bight of the North Sea)6个站位取样鉴定了13个小型底栖动物类群。其中线虫Nematoda、底栖桡足类Copepoda、涡虫Turbellaria、多毛类Polychaeta和水螅Hydrozoa在各站均有发现。线虫与桡足类丰度比率R为1.2~30.7。701站和435站以较低的类群组成和多样性指标、以较高的R比率而明显区别于其它各站。分析结果表明:该两个站位小型底栖群落结构除了沉积物类型因素外,巳受到污染的严重影响。比利时沿岸701站的污染源来自Western Scheldt河长年携带大量工业废物和生活污水的入侵,而435站则归因于TiO_2废物的倾倒活动。陈国通 Magda Vincx Carlo Heip 1992海洋通报1992,11,5:8
6Evaluation of patients with dry eye disease for conjunctival Chlamydia trachomatis and Ureaplasma urealyticum显示文摘AIM:To determine the possibility of the development of dry eye disease(DED) as a result of persistent infection with Chlamydia trachomatis and Ureaplasma urealyticum in the conjunctiva of patients.METHODS: This study was conducted on 58 patients of age range 20-50 y,diagnosed with DED confirmed by Schirmer I test and tear breakup time.The non-dry eye control group included 27 subjects of the same age.Ocular specimens were collected as conjunctival scrapings and swabs divided into three groups: the first used for bacterial culture,the second and third taken to detect Chlamydia trachomatis and Ureaplasma urealyticum by direct fluorescent antibody(DFA) assay and polymerase chain reaction(PCR) method. RESULTS: Chlamydia trachomatis was detected in 65.5% and 76% of DED patients by DFA and PCR methods respectively.Ureaplasma urealyticum was found in 44.8% of DED infected patients using the PCR method.Both organisms were identified in only 37.9% of DED patients found to be infected.Control subjects had a 22%detection rate of Chlamydia trachomatis by DFA assay versus a 7% detection rate by PCR; while Ureaplasma urealyticum was detected in 3.7% of the controls by PCR method.The conjunctival culture revealed that gram positive microorganisms represented 75% of isolates with coagulase negative Staphylococci the most common(50%) followed by Staphylococcus aureus(20%),whereas gram negative microorganisms occurred in 25% of cases,isolating Moraxella spp.as the most frequent organism. CONCLUSION: Our results tend to point out that Chlamydia trachomatis and Ureaplasma urealyticum were detected in a moderate percentage of patients with DED,and could be a fair possibility for its development.PCR is more reliable in detecting Chlamydia trachomatis than DFA technique.The presence of isolated conjunctival bacterial microflora can be of some potential value.Maha Mohssen Abdelfattah Rania Abdelmonem Khattab Magda H.Mahran Ebrahim S.Elborgy 2016International Journal of Ophthalmology(English edition)2016,9,10:6
7HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination.Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy 2011World Journal of Hepatology2011,3,6:5
8VDR-Taq Ⅰ、Fok Ⅰ位点多态性与宁夏人群结核易感性研究显示文摘目的探讨维生素D受体(VDR)基因TaqⅠ、FokⅠ位点基因多态性与宁夏回族自治区人群肺结核易患性之间的关系。方法搜集宁夏南部8个地区2010年7—11月确诊的肺结核患者993例(简称'病例组'),其中男550例,女443例;同期选择来源地区,与病例组性别相同、民族相同、年龄相当、居住环境相匹配的确认无肺结核的健康人880名(简称'对照组'),其中男485名,女395名。将聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测VDR基因多态性的方法,应用于人群结核病易感性的病例-对照研究。用SPSS 16.0软件对检测结果进行数据统计,各基因型与结核易感性关系用单因素分析和多因素logistic回归分析,以P<0.05为差异有统计学意义。结果VDR-TT、Tt、tt基因型在病例组和对照组中分布频率分别为83.0%(815/982)、15.2%(149/982)、1.8%(18/982)和84.7%(739/872)、14.7%(128/872)、0.6%(5/872),病例组与对照组差异有统计学意义(χ2=6.15,P=0.046)。VDR-FF、Ff、ff基因型病例组和对照组分布频率分别为32.4%(316/976)、47.9%(468/976)、19.7%(192/976)和28.5%(245/861)、53.3%(459/861)、18.2%(157/861),病例组和对照组分布差异无统计学意义(χ2=5.41,P=0.067)。在显性基因模型中,VDR-(TT+Tt)、tt基因型病例组和对照组中分布频率分别为98.2%(964/982)、1.8%(18/982)和99.4%(867/872)、0.6%(5/872),病例组和对照组中分布差异有统计学意义(χ2=5.98,P=0.014;OR=0.98、3.19,95%CI=0.978~0.997、1.193~8.574);在纯合基因模型中VDR-(FF+ff)、Ff基因型在病例组和对照组中频率分别为52.0%(508/976)、48.0%(468/976)和46.7%(402/861)、53.3%(459/861),病例组和对照组分布差异有统计学意义(χ2=5.27,P=0.022;OR=1.12、0.89,95%CI=1.023~1.298、0.822~0.985)。结论在宁夏人群中,肺结核易患性可能与VDR-TaqⅠ、FokⅠ位点多态性有关联,VDR-(FF+ff)、tt基因型可能是罹患肺结核的危险因素,而VDR-(TT+Tt)、Ff基因型可能是保护因素。陈丹丹 朱圭娜 关光玉 Magda Ellis Donald P. McManus 杨玉荣 2013中国防痨杂志2013,35,8:5
9Crystallographically Selective Nanopatterning of Graphene on SiO_(2)显示文摘Graphene has many advantageous properties,but its lack of an electronic band gap makes this two-dimensional material impractical for many nanoelectronic applications,for example,field-effect transistors.This problem can be circumvented by opening up a confinement-induced gap,through the patterning of graphene into ribbons having widths of a few nanometres.The electronic properties of such ribbons depend on both their size and the crystallographic orientation of the ribbon edges.Therefore,etching processes that are able to differentiate between the zigzag and armchair type edge terminations of graphene are highly sought after.In this contribution we show that such an anisotropic,dry etching reaction is possible and we use it to obtain graphene ribbons with zigzag edges.We demonstrate that the starting positions for the carbon removal reaction can be tailored at will with precision.Péter Nemes-Incze Gábor Magda Katalin Kamarás LászlóPéter Biró 2010Nano Research2010,3,2:4
10Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation.Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat 2013World Journal of Hepatology2013,5,2:4
11A Secure Elliptic Curve-Based RFID Protocol显示文摘Nowadays, the use of Radio Frequency Identification (RFID) systems in industry and stores has increased. Nevertheless, some of these systems present privacy problems that may discourage potential users. Hence, high confidence and efficient privacy protocols are urgently needed. Previous studies in the literature proposed schemes that are proven to be secure, but they have scalability problems. A feasible and scalable protocol to guarantee privacy is presented in this paper. The proposed protocol uses elliptic curve cryptography combined with a zero knowledge-based authentication scheme. An analysis to prove the system secure, and even forward secure is also provided.Santi Martínez Magda Valls Concepció Roig Josep M. Miret Francesc Giné 2009Journal of Computer Science & Technology2009,24,2:3
12Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations.Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans 2017World Journal of Transplantation2017,7,5:3
13低能重离子诱导反应中轻带电粒子和蒸发剩余物的能谱(英文)显示文摘在多源理想气体模型的框架内,用一个关于末态粒子多重数分布的统一描述,研究了低能重离子诱导反应中轻带电粒子和蒸发剩余物的能谱。在同一个激发的复合核中,每个源对带电粒子和蒸发剩余物均贡献一个指数分布的能谱。计算结果与158,170,180和200MeV20Ne+12C反应中,轻带电粒子和蒸发剩余物能谱的实验结果符合。吕绮雯 卫华荣 Rahim Magda A Fakhraddin S 刘福虎 2012原子核物理评论2012,29,1:2
14Designer uniform Li plating/stripping through lithium–cobalt alloying hierarchical scaffolds for scalable high-performance lithium-metal anodes显示文摘Lithium metal anodes are of great interest for advanced high-energy density batteries such as lithiumair, lithium-sulfur and solid-state batteries, due to their low electrode potential and ultra-high theoretical capacity. There are, however, several challenges limiting their practical applications, which include low coulombic efficiency, the uncontrollable growth of dendrites and poor rate capability. Here, a rational design of 3D structured lithium metal anodes comprising of in-situ growth of cobalt-decorated nitrogen-doped carbon nanotubes on continuous carbon nanofibers is demonstrated via electrospinning.The porous and free-standing scaffold can enhance the tolerance to stresses resulting from the intrinsic volume change during Li plating/stripping, delivering a significant boost in both charge/discharge rates and stable cycling performance. A binary Co-Li alloying phase was generated at the initial discharge process, creating more active sites for the Li nucleation and uniform deposition. Characterization and density functional theory calculations show that the conductive and uniformly distributed cobalt-decorated carbon nanotubes with hierarchical structure can effectively reduce the local current density and more easily absorb Li atoms, leading to more uniform Li nucleation during plating. The current work presents an advance on scalable and cost-effective strategies for novel electrode materials with 3D hierarchical microstructures and mechanical flexibility for lithium metal anodes.Xinhua Liu Xiaojuan Qian Weiqiang Tang Hui Luo Yan Zhao Rui Tan Mo Qiao Xinlei Gao Yang Hua Huizhi Wang Shuangliang Zhao Chao Lai Magda Titirici Nigel PBrandon Shichun Yang Billy Wub 2021Journal of Energy Chemistry2021,30,1:2
15SLC11A1基因多态性与宁夏南部人群肺结核易感性研究显示文摘目的 探索SLC11A1基因rs17235409、rs17235416、rs3731865等位点多态性与中国宁夏回族自治区南部人群肺结核易感性的关系.方法 于2010年7-11月选取宁夏回族自治区南部的西吉、海原、泾原、彭阳、原州、同心、中卫、隆德等8个地区,并在该地区居住10年以上,且经当地疾病预防控制中心确诊为活动性肺结核的患者作为观察组,共965例.同期选取上述地区的健康人群作为对照组,共897名.收集研究对象基本信息,采集研究对象外周静脉血5 ml,应用乙二胺四乙酸(EDTA)抗凝,-80℃保存,用于提取基因组DNA.利用聚合酶链反应限制性片段长度多态性(PCR-RFLP)的方法对SLC11A1基因rs17235409、rs17235416、rs3731865位点进行基因分型,分析3个单核苷酸多态性(SNP)位点与结核易感性的关系.结果 rs17235409位点AA、AG、GG基因型在观察组和对照组中分布频率分别为1.4%(13/950)、23.5%(223/950)、75.1%(714/950)和2.7% (23/842)、25.1%(211/842)、72.2%(608/842),两组比较差异无统计学意义(x2=5.12,P=0.077);rs17235416位点TGTG(-)/(-)、TGTG(+)/(-)、TGTG(+)/(+)基因型在观察组和对照组中的分布频率分别为1.8%(17/939)、22.7%(213/939)、75.5%(709/939)和3.4%(28/824)、23.8%(196/824)、72.8%(600/824),两组比较差异无统计学意义(x2=4.99,P=0.082);rs3731865位点CC、GC、GG基因型在观察组和对照组中分布频率分别为2.3%(22/951)、26.1%(248/951)、71.6%(681/951)和2.4%(20/843)、24.9%(210/843)、72.7%(613/843),两组比较差异无统计学意义(x2 =0.32,P=0.852).在隐性模型中,rs17235409位点AA、AG+ GG-基因型在观察组和对照组中分布频率分别为1.4%(13/950)、98.6%(937/950)和2.7%(23/842)、97.3%(819/842),两组分布频率比较差异有统计学意义(x2=4.21,P=0.040);但多因素logistic回归分析结果与单因素结果不-致,说明条件因素包括性别、年龄、民族等不同对结果有一定影响,所以不能说明rs17235409位点与肺结核发病相关(OR=0.51,95%CI=0.25~1.03,P=0.060).rs17235416位点TGTG(-)/(-)、TGTG(+)/(-)+TGTG(+)/(+)基因型在观察组和对照组中分布频率分别为1.8%(17/939)、98.2%(922/939)和3.4%(28/824)、96.6%(796/824),两组分布频率比较差异有统计学意义(x2 =4.45,P=0.038,OR=0.52、1.91,95%CI=0.23~0.97、1.04~3.51);经多因素logistic回归分析,排除性别、年龄和民族等条件因素对结果的影响,多因素结果与单因素结果相似,发现条件因素对结果无影响,结果仍有意义,说明携带rs17235416位点TGTG(+)/(-)和(或)TGTG(+)/(+)基因型的个体较携带TGTG(-)/(-)基因型的个体患肺结核的风险增加(OR=0.54,95%CI:0.29~1.00,P=0.049).结论 SLC11A1基因rs17235409和rs3731865位点多态性与宁夏南部地区人群肺结核易感性不相关.而rs17235416位点在隐性模型中,即携带TGTG(+)/(-)与TGTG(+)/(+)基因型的个体发病风险增高.朱圭娜 侯怀哲 尹媛婕 陈丹丹 Ellis K. Magda 关光玉 杨书鲲 杨延辉 Donald P. McManus 景永峰 王平 杨玉荣 2017中国防痨杂志2017,39,10:2
16The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner显示文摘Magda Kucia Wojtek Wojakowski Ryan Reca Bogdan Machalinski Jolanta Gozdzik Marcin Majka Jarek Baran Janina Ratajczak Mariusz Z. Ratajczak 2006Archivum Immunologiae et Therapiae Experimentalis2006,,2:2
17The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage显示文摘Ahmed O. Abdel-Zaher Randa H. Abdel-Hady Madeha M. Mahmoud Magda M.Y. Farrag 2007Toxicology2007,,3:2
18Identification and estimation of the biomass burning contribution to Beijing aerosol using levoglucosan as a molecular marker显示文摘Ting Zhang Magda Claeys Hélène Cachier Shuping Dong Wan Wang Willy Maenhaut Xiande Liu 2008Atmospheric Environment2008,,29:2
19Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease显示文摘Jannis Kountouras Marina Boziki Emmanuel Gavalas Christos Zavos Nikolaos Grigoriadis Georgia Deretzi Dimitrios Tzilves Panagiotis Katsinelos Magda Tsolaki Dimitrios Chatzopoulos Ioannis Venizelos 2009Journal of Neurology2009,,5:2
20Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes显示文摘Diego Sbardella Giovanni Francesco Fasciglione Magda Gioia Chiara Ciaccio Grazia Raffaella Tundo Stefano Marini Massimo Coletta 2011Molecular Aspects of Medicine2011,,2:2
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