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| 1 | 石榴健胃散干预对实验性结肠炎小鼠肠道免疫功能的影响显示文摘目的探讨石榴健胃散干预对C.rodentium感染所致实验性结肠炎小鼠肠道免疫功能的影响。方法将24只雌性BALB/c小鼠适应性饲养7 d后随机分为正常组、药物组(1.5g/kg)、感染组、感染+药物组(1.5g/kg),每组6只。观察感染组和感染+药物组(1.5g/kg)小鼠感染第2、6、10、13 d时粪便排菌量和体重变化;13 d病程期后取材观察结肠长度及结肠组织形态学变化;检测肠系膜淋巴结T淋巴细胞培养液上清中γ-干扰素(IFN-γ)、白介素-10(IL-10)、白介素-17(IL-17)及血清IgG2a的含量;检测结肠组织中细胞因子(IFN-γ、TNF-α、IL-10、IL-17)、转录因子(T-bet、RORrt)mRNA的表达量。结果 (1)感染组和感染+药物组小鼠体重均出现明显下降但无差异。(2)感染组和感染+药物组小鼠在感染第2、6、10、13 d时的粪便排菌量无明显差异。(3)感染组小鼠结肠长度明显缩短,感染+药物组小鼠结肠长度延长(与正常组比较无差异)。(4)与感染组比较,感染+给药组血清中IgG2a抗体浓度升高;肠系膜淋巴结T淋巴细胞培养液上清中IFN-γ含量下降,IL-10含量升高,IL-17含量无明显变化;结肠组织中的IFN-γ、TNF-α、T-bet表达降低,IL-10表达升高,IL-17、RORrt表达无明显变化。(5)感染组结肠组织上皮细胞脱落,局部炎性细胞增多,形成淋巴滤泡;感染+给药组上皮结构相对完整,炎性细胞较少,隐窝明显延长。结论石榴健胃散干预对C.rodentium感染所致实验性结肠炎小鼠肠道免疫功能存在有益作用,这种作用可能通过抑制Th1反应实现。 | 申香群 仁增多杰 马倩倩 朱沁芳 Mohamed Magged 张伟 任延明 | 2021 | 中国高原医学与生物学杂志2021，42，2： | 3 |
| 2 | Simulation of transpiration, drainage, N uptake, nitrate leaching, and N uptake concentration in tomato grown in open substrate显示文摘 | M. Gallardo R.B. Thompson J.S. Rodríguez F. Rodríguez M.D. Fernández J.A. Sánchez J.J. Magán | 2009 | Agricultural Water Management2009，，12： | 2 |
| 3 | SOX2,a persistent marker for multipotential neural stem cells derived from embryonic stem cells,the embryo or the adult显示文摘 | Ellis P Fagan B M Magness S T | | 0，，24： | 2 |
| 4 | High strain rate deformation behaviors of kinetic energy penetrator materials during ballistic impact 显示文摘 | MAGNESS L S | 1994 | Mechanics of Materials1994，17，23： | 1 |
| 5 | Nitric oxide and pregnancy 显示文摘 | S1ade SM Magness RR Conrad KP | 1997 | AM JPhysiol1997，272，： | 1 |
| 6 | HealthAgents: distributed multi-agent brain tumor diagnosis and?prognosis显示文摘 | Horacio González-Vélez Mariola Mier Margarida Julià-Sapé Theodoros N. Arvanitis Juan M. García-Gómez Montserrat Robles Paul H. Lewis Srinandan Dasmahapatra David Dupplaw Andrew Peet Carles Arús Bernardo Celda Sabine Huffel Magí Lluch-Ariet | 2009 | Applied Intelligence2009，，3： | 1 |
| 7 | Preparation of uniformed-sized PLA microcapsules by combining Shirasu Porous Glass membrane emulsification technique and multiple emulsion-solvent evaporation method显示文摘 | LiuR MaG H MengFT | 2005 | J Control Release2005，103，： | 1 |
| 8 | Myeloid-derived suppressor cells as an immune parameter in patients with concurrent sunitinib and stereotactic body radiotherapy显示文摘 | ChenHM MaG Gildener-LeapmanN | 2015 | Clin Cancer Res2015，21，18： | 1 |
| 9 | Polarographic determination of sunscreen agents in cosmetic products in mitellar media显示文摘 | DA SILVA AP TRINDADE MAG FERREIRA VS | 2006 | Talanta2006，68，3： | 1 |
| 10 | SOX2 is a dosedependent regulator of retinal neural progenitor competence显示文摘 | Taranova OV Magness ST Fagan BM | | 0，，09： | 1 |
| 11 | Nitric oxide andpregnancy显示文摘 | Sladek SM Magness RR Conrad KP | 1997 | Am J Physiol1997，272，22： | 1 |
| 12 | Nitric oxide and pregnancy显示文摘 | Sladek SM Magness R R Conrad K P | 1997 | Am J physiology1997，272，： | 1 |
| 13 | Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania 显示文摘 | Tanure MAG Cohen E J Sudesh S | 2000 | Cornea2000，19，3： | 1 |
| 14 | Spectrum of fungal keratitis at Wills eye hospital, Philadelphia, Pennsylvania 显示文摘 | Tanure MAG Cohen E J Sudesh S | 2000 | Cornea2000，19，： | 1 |
| 15 | Simulation of transpiration, drainage, N uptake, nitrate leaching, and N uptake concentration in tomato grown in open substrate显示文摘 | M. Gallardo R.B. Thompson J.S. Rodríguez F. Rodríguez M.D. Fernández J.A. Sánchez J.J. Magán | 2009 | Agricultural Water Management2009，，12： | 1 |
| 16 | Serum levels of procalcitonin as a biomarker for differentiating between sepsis and systemic inflammatory response syndrome in the neurological intensive care unit显示文摘 | TianG PanSY MaG | 2014 | J Clin Neurosci2014，21，11： | 1 |
| 17 | Possible mecha-nisms underlying pregnancy-induced changes in uterineartery endothelial function 显示文摘 | Bird I M Zhang L B Magness R R | 2003 | American Journal ofRegulatary Comparative Physiology2003，284，2： | 1 |
| 18 | Susceptibility ofsome bacterial contaminants recovered from commercial cosm-etics in Jordan to preservatives and antibiotics 显示文摘 | Qasem MAS Walid AI-Momani Rania MAG | 2014 | TropicalJournal of Pharmaceutical Research2014，13，2： | 1 |
| 19 | Statistical aspects of the contin-uous damage theory显示文摘 | Krajcinovic D Silva MAG | 1982 | International Journal of Solids andStructures1982，18，17： | 1 |
| 20 | Beat-to?beat variability of repolarization as a new biomarker for proarrhythmia in vivo显示文摘 | Varkevisser R Wijers SC van der Heyden MAG | 2012 | Heart Rhythm2012，9，： | 1 |
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