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| 1 | Ikaros in B cell development and function显示文摘The zinc finger transcription factor,Ikaros,is a central regulator of hematopoiesis.It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptor expression.Mature B cells rely on Ikaros to set the activation threshold for various stimuli,and to choose the correct antibody isotype during class switch recombination.Thus,Ikaros contributes to nearly every level of B cell differentiation and function. | MacLean Sellars Philippe Kastner Susan Chan | 2011 | World Journal of Biological Chemistry2011，2，6： | 3 |
| 2 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 3 | 职业教育与高等教育:问题、关注点和发展前景显示文摘从历史的角度来说,职业教育和高等教育源自截然不同的教育传统,大学一般生产系统的科学知识,而职业教育则提供某一特定职业的培训。随着时间的推移,这两者之间的关系也受到了社会经济发展过程的影响。在世界范围内,一个国家之内的精英高等教育机构、大众化高等教育机构、多科技术学院以及不同层次的职业教育机构间形成了复杂的关系。即使在都是以资本主义经济为主体的德国和英国等欧盟国家,也采用了不同的高等教育和职业教育实施方法。 | Rupert Maclean | 2007 | 职业技术教育2007，28，18： | 3 |
| 4 | 雄激素受体的目标基因在骨骼肌的表达显示文摘本文通过研究体外和体内模型中潜在的雄激素受体调节基因来确定骨骼肌中雄激素的合成代谢作用机制。睾酮治疗组的去势雄性小鼠与对照组去势雄性小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著下降,而缺乏DNA结合活性的雄性雄激素受体敲除小鼠(AR^△ZF2)与野生型小鼠比较,其骨骼肌中肌源性调节因子肌细胞生成素的表达显著升高,证明了肌细胞生成素是通过雄激素/雄激素受体通路被抑制。通过12小时的骨骼肌细胞(SkMC)的成肌细胞联合双氢睾酮治疗,睾酮治疗组的去势雄性小鼠肌肉中的泛素连接酶Fbxo32被抑制,而肌肉中c—Myc表达较对照组去势雄性小鼠降低,在△R^△ZF2组小鼠肌肉中c-Myc表达升高。调节成肌细胞由增殖向分化转变的一组基因如Tceal7,p57^Kip2,Igf2和钙调磷酸酶Aa的表达在AR^△ZF2组小鼠肌肉中升高,除p57^Kip2外的上述所有基因在睾酮治疗组去势雄性小鼠肌肉中的表达均较对照组降低。因此得出结论,雄激素通过雄激素受体在雄性小鼠体内发挥作用,它在肌肉生长和发展过程中可维持成肌细胞处于增殖状态并推迟成肌细胞向分化状态转变,另外还可抑制泛素连接酶介导的导致肌肉萎缩的通路来保持小鼠肌肉质量,从而一定程度上促进肌肉不断生长达到顶峰。 | Kesha Rana Nicole KL Lee Jeffrey D Zajac Helen E MacLean | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 5 | 加拿大综合教育组织有效的领导与管理显示文摘2007年10月,中央校成功举办全国农广校系统师资能力建设远程培训班。来自美国、加拿大及联合国粮农组织的4位专家就教育机构领导与管理、教育技术与学习支持系统和农村人口教育作了专题讲座。专家讲座的幻灯片文件已在'中国农村远程教育网'的'国际远教广角'栏目登载。应农广校系统广大教职员工的要求,中央农广校对外交流处组织翻译、整理了专家的讲稿,本刊将连续三期摘编专家的中文讲稿,供大家学习交流。本文作者Scott Maclean博士现任加拿大卡尔加里大学继续教育学院主任,在成人教育、继续教育和远程教育领域里的学术性杂志上发表了多篇文章。Scott Maclean博士效力于加拿大的大学继续教育协会,社会科学和人文科学研究理事会,现任中央农广校专家组国际咨询专家。此报告是应中央农广校体系师资能力建设远程培训之邀所准备。 | Scott Maclean | 2008 | 农民科技培训2008，，1： | 2 |
| 6 | 庭审中的专家:发现科学证据中的认知偏差显示文摘一、引言数百年来,法庭制定了许多证据规则和程序规则,旨在防止不可靠的信息污染审判过程。这些规则体系在某些方面成效很好,但在其他方面成效不佳。关于专家意见证据(Expert Opinion Evidence),法庭试图消除或纠正可能存在的偏差,主要是故意偏差。但是,迄今为止,法庭尚未发展出有效的方法,以识别和抵消专家的认知偏差,这些认知偏差是由影响证据质量的潜意识因素导致的(例如,能使决策产生偏差的无关情境信息)。 | 朱海(译) 王进喜 | 2021 | 证据科学2021，29，4： | 2 |
| 7 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 8 | Detection of hydrocarbon fuel spills using a distributed fibre optic sensor显示文摘 | Alistair MacLean Chris Moran Walter Johnstone Brian Culshaw Dan Marsh Paul Parker | 2003 | Physical2003，，1： | 2 |
| 9 | Contractile responses to human urotensinⅡin rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat显示文摘 | Maclean M R Alexander D Atirrat A | 2000 | Br J Pharmacol2000，130，2： | 2 |
| 10 | Skeletal muscle sterol regulatory element binding protein-1c decreases with food deprivation and increases with feeding in rats显示文摘 | BIZEAU M E MACLEAN P S JOHNSON G C | 2003 | The Journal of Nutrition2003，133，： | 1 |
| 11 | Assessing care of vulnerable elders:methods for developing quality indicators 显示文摘 | Shekelle PG MacLean CH Morton SC | 2001 | Ann Intern Med2001，135，8： | 1 |
| 12 | Proliferation and signal- ing in fibroblasts : Role of 5-hydroxytryptamine receptor and trans- porter 显示文摘 | Welsh D J Harnett M MacLean M | 2004 | Am J Respir Crit Care Med2004，1170，3： | 1 |
| 13 | Conditioned emergence: A dissipative structures approach to transformation显示文摘 | Macintosh R Maclean D | 1999 | Strategic Management Journal1999，20，： | 1 |
| 14 | Risk of small bowel obstruction after the ileal pouch-anal anastomosis显示文摘 | MacLean AR Cohen Z MacRae HM | 2002 | Ann Surg2002，235，2： | 1 |
| 15 | The minimum positionalerror incurred by any connectivity-based positioning algo-rithm for mobile wireless systems 显示文摘 | Stuart MacLean Suprakash Datta | 2011 | Theoretical Comput-er Science2011，412，50： | 1 |
| 16 | Mirror display in the squirrel monkeys, Saimirisciureus显示文摘 | Maclean PD | 1964 | Science1964，146，： | 1 |
| 17 | Screening and management of adult hearing loss in primary care:scientific review显示文摘 | Yueh B Shapiro N MacLean CH | 2003 | JAMA2003，289，15： | 1 |
| 18 | Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression 显示文摘 | Maclean JJ Lee CR Alini M | 2004 | J Orthop Res2004，22，6： | 1 |
| 19 | A quantitative relationship between forest growth rates and thematic mapper reflectance measurements显示文摘 | Ahern F J Erdle T Maclean D A | 1991 | International Journal of Remote Sensing1991，12，3： | 1 |
| 20 | Phylogenetic relationships between some members of the genera Neisseria , Acinetobacter, Moraxella , and Kingella based on partial 16S ribosomal DNA sequence analysis显示文摘 | ENRIGHT M C CCARTER P E MACLEAN I A | 1994 | Int J Syst Bacteriol1994，44，3： | 1 |
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