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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Research on Glutamate Synthase Activity in Sugar Beet(Beta Vulgaris L.)under Different Levels of Nitrogen显示文摘ResearchonGlutamateSynthaseActivityinSugarBeet(BetaVulgarisL.)underDifferentLevelsofNitrogenYanGuiping,MaFengming,LiWenhuaand... | Yan Guiping, Ma Fengming, Li Wenhua and Gao Jiguo (Northeast Agricultural University, Harbin 150030 PRC) | 1998 | Journal of Northeast Agricultural University(English Edition)1998，5，1： | 7 |
| 3 | Flexible, Porous, and Metal–Heteroatom?Doped Carbon Nanofibers as Efficient ORR Electrocatalysts for Zn–Air Battery显示文摘Developing an e cient and durable oxygen reduction electrocatalyst is critical for clean-energy technology, such as fuel cells and metal–air batteries. In this study, we developed a facile strategy for the preparation of flexible, porous, and well-dispersed metal–heteroatom-doped carbon nanofibers by direct carbonization of electrospun Zn/Co-ZIFs/PAN nanofibers(Zn/Co-ZIFs/PAN). The obtained Zn/Co and N co-doped porous carbon nanofibers carbonized at 800 °C(Zn/Co–N@PCNFs-800) presented a good flexibility, a continuous porous structure, and a superior oxygen reduction reaction(ORR) catalytic activity to that of commercial 20 wt% Pt/C, in terms of its onset potential(0.98 V vs. RHE), half-wave potential(0.89 V vs. RHE), and limiting current density(-5.26 mA cm^(-2)). In addition, we tested the suitability and durability of Zn/Co–N@PCNFs-800 as the oxygen cathode for a rechargeable Zn–air battery. The prepared Zn–air batteries exhibited a higher power density(83.5 mW cm^(-2)), a higher specific capacity(640.3 mAh g^(-1)), an excellent reversibility, and a better cycling life than the commercial 20 wt% Pt/C + RuO_2 catalysts. This design strategy of flexible porous non-precious metal-doped ORR electrocatalysts obtained from electrospun ZIFs/polymer nanofibers could be extended to fabricate other novel, stable, and easy-to-use multi-functional electrocatalysts for clean-energy technology. | Qijian Niu Binling Chen Junxia Guo Jun Nie Xindong Guo Guiping Ma | 2019 | Nano-Micro Letters2019，11，1： | 7 |
| 4 | Preparation of multi-color quantum dots and its application to immunohistochemical analysis显示文摘Quantum dots (QDs) have the potential to be used in the multiplexed bioanalysis for their unique property:multi-color QDs can be excited at the same single wavelength light. In this work,high quan-tum yield multi-color core/shell QDs were prepared. After being water-solubilized by amphiphilic polymer based on self-assembling,the QDs would be labeled by two different IgGs and used in the multiplexed biodetection. Fluorescence resonance energy transfer (FRET) should be avoided in the multiplexed biodetection. In this work,spectral analysis showed that no FRET appeared in water-soluble QDs modified by amphiphilic polymer. The immunofluorescence in vitro indicated that the QDs-IgGs bioconjugates had excellent species-specific detection ability with nearly non-specific binding. The setting of this model will help to support the application of multi-color QDs in the multiplexed bioanalysis communities. | ZHANG BingBo LIU XuHui LI DeNa TIAN Hui MA GuiPing CHANG Jin | 2008 | Chinese Science Bulletin2008，53，13： | 6 |
| 5 | Recent studies in satellite observations of three-dimensional magnetic reconnection显示文摘Magnetic reconnection is a main process converting the magnetic energy into thermal and kinetic energy in plasmas. It is one of the fundamental problems of crucial importance not only to space plasmas physics and space weather studies,such as the solar flare,coronal mass ejections and magnetospheric substorms,but also to the stability analysis in magnetically confined fusion. In general,except for cases with periodical boundary conditions,three-dimensional(3D) magnetic re-connection occurs on magnetic separatrices generated by magnetic nulls. Here we briefly introduce/review the theories and some recent satellite observations of 3D magnetic reconnection. Topics to be further studied are also discussed. | XIAO ChiJie WANG XiaoGang PU ZuYin MA ZhiWei ZHAO Hui ZHOU GuiPing WANG JingXiu LIU ZhenXing | 2007 | Science China(Technological Sciences)2007，50，3： | 4 |
| 6 | Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial显示文摘Importance:Recurrent respiratory tract infection(RRTI)is common in children.Inappropriate RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of children.Immune function modulation can prevent and alleviate childhood RRTI.Yupingfeng(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with RRTI.Objective:To evaluate the safety and efficacy of YPF monotherapy in treating children with RRTI.Methods:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug withdrawal.Children aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or placebo.The primary outcome was the proportion of RRTI returning to normal standard level during the follow-up.The secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and safety.The trial was registered at the Chinese Clinical Trials Registry(www.chictr.org.cn)under the unique identifier ChiCTR-IPR-15006847.Results:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the trial.During the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo group.The safety profile did not significantly differ among the groups.Interpretation:YPF granules were noninferior to the active control drug pidotimod oral solution for the treatment of RRTI in children,and were superior to placebo,with a high safety profile. | Baoping Xu Xinmin Li Siyuan Hu Yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei Liu Yufeng Liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui Liu Lei Li Rong Ma Kunling Shen | 2022 | Pediatric Investigation2022，6，2： | 3 |
| 7 | Electrospun Core-Shell Fibrous 2D Scaffold with Biocompatible Poly(Glycerol Sebacate) and Poly-l-Lactic Acid for Wound Healing显示文摘Biomimetic scaffolds made by synthetic materials are usually used to replace the natural tissues aimed at speeding up the skin regeneration.In this study,a flexible and cytocompatible poly(glycerol sebacate)@poly-l-lactic acid(PGS@PLLA)fibrous scaffold with a core-shell structure was fabricated by coaxial electrospinning,where the shell PLLA was used to be a skeleton with pores on the fibrous surface.The fibrous morphology with pores on the surface of the prepared fibers was observed by SEM.The core-shell microstructure of PGS@PLLA fibers was confirmed by TEM and Laser Scanning Confocal Microscopy(LSCM).In addition,the prepared fibers exhibited a strong ability to repair tissues of the skin wound,where the stability of cell security and proliferation,and the lower inflammatory response were all superior to those of pure PLLA scaffold.It’s worth noting that the percentage of skin tissue was regenerated by 95%within 14 days,which suggests the potential application for electrospun-based synthetic fibrous scaffolds on wound healing. | Xiaoping Yang Lingfeng Li Dongzhi Yang Jun Nie Guiping Ma | 2020 | Advanced Fiber Materials2020，2，2： | 2 |
| 8 | Effects of solution properties and electric field on the electrospinning of hyaluronic acid显示文摘 | Liu Yang Ma Guiping Fang Dawei | | 0，，02： | 1 |
| 9 | Electrospun sodium alginate/poly(ethylene oxide) core–shell nanofibers scaffolds potential for tissue engineering applications显示文摘 | Guiping Ma Dawei Fang Yang Liu Xiaodan Zhu Jun Nie | 2011 | Carbohydrate Polymers2011，，1： | 1 |
| 10 | Prepara- tion and characterization of N-alkylated chitosan deriva- tives显示文摘 | Ma Guiping Yang Dongzhi Tan Hailin | 2008 | Journal of Applied Polymer Science2008，109，2： | 1 |
| 11 | Preparation and characterization of N-alkylated chitosan derivatives 显示文摘 | MA Guiping YANG Dongzhi TAN Hailin | 2008 | Journal Applied Plymer Science2008，109，： | 1 |
| 12 | Preparation and characterization of N-alkylated chitosan derivatives显示文摘 | MA GUIPING YANG DONGZHI TAN HAILIN | 2008 | Appl Polymer Sci2008，109，2： | 1 |
| 13 | Design and characterization of antitumor drug paclitaxel-loaded chitosan nanoparticles by W/O emulsions显示文摘 | Juan Xu Lili Ma Yang Liu Fei Xu Jun Nie Guiping Ma | 2012 | International Journal of Biological Macromolecules2012，，2： | 1 |
| 14 | Synthesis and properties of photo sensitive chitosan derivatives 显示文摘 | Ma Guiping Qian Bin Yang Jianxin | 2010 | International Journal of Biological Macromolecules2010，46，2： | 1 |
| 15 | Synthesize and characterization of organic soluble acy lated chitosan显示文摘 | Ma Guiping Yang Dongzhi John F Kennedy | 2009 | Carbohydrate Polymers2009，75，： | 1 |
| 16 | Preparation and characterization of water-soluble N- alkylated chitosan显示文摘 | Ma Guiping Yang Dongzhi Zhou Yingshan | 2008 | Carbohydrate Polymers2008，74，1： | 1 |
| 17 | Fabrication and characterization of chitosan/PVA with hydroxyapatite biocomposite nanoscaffolds 显示文摘 | Yang Dongzhi Jin Yu Ma Guiping | 2008 | Journal of Applied Polymer Science2008，110，6： | 1 |
| 18 | Preparation of porous ultrafine polyacrylonitrile (PAN) fibers by elec- trospinning 显示文摘 | MA Guiping YANG Dongzhi NIE Jun | 2009 | Polymers for Advanced Technologies2009，20，2： | 1 |
| 19 | Research on ultracold cesium molecule long-range states by high-resolution photoassociative spectroscopy显示文摘In this paper, an ultra-high resolution photoassociation spectroscopy study on photoassociation of cesium atoms is reported. The cold cesium gas in the mag-neto-optical trap is illuminated by a photoassociation laser with red-tuning as large as 40 cm?1 below the 6S1/2 + 6P3/2 dissociation limit, and the photoassociation to the excited state ultracold molecule is detected. High signal-to-noise ratio is obtained by using the lock-in detection of the fluorescence from the modulated cold Cs at-oms. The 0g?, 1g and 0u+ long-range states which correspond to 6S1/2 + 6P3/2 dissocia-tion limit are present in the photoassociation spectrum. The effective coefficients of leading long-range interactions and the corresponding vibrational quantum num-ber are obtained using LeRoy-Bernstein Law. It is found that photoassociation process creates rotating molecules and the high J value is a hint that higher partial waves participate in the PA process in the presence of trapping laser. | WANG LiRong MA Jie JI WeiBang WANG GuiPing XIAO LianTuan JIA SuoTang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，2： | 1 |
| 20 | Adsorption performance and mechanism in binding of Reactive Red 4 by coke waste显示文摘 | Wu Guiping Ma Hui | 2006 | Journal of Hazardous Materials2006，138，： | 1 |
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