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| 1 | Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns显示文摘 | Wei Xiao Qing-Fang Duan Wen-Ya Fu Xin-Zuo Chi Feng-Ying Wang Da-Qing Ma Tian-Long Wang Lei Zhao | 2015 | Chinese Medical Journal2015，，14： | 35 |
| 2 | Microstructure and Properties of Hot Working Die Steel H13MOD显示文摘Compared with H13 steel,the influences of different heat treatment process on the microstructure and properties of the new type of hot working die steel H13MOD were studied.The results show that the complete austenitizing temperature of H13MOD is around 1 030℃ and the quenching hardness achieves the maximum value at this temperature.While for H13,the complete austenitizing temperature is above 1 100℃ and the quenching hardness rise constantly with the quenching temperature increasing.In quenching process,the undissolved MC carbides can prevent the coarsening of grain in both steels.With the rise of quenching temperature,when MC carbides dissolve completely,the grain grows quickly.The hardness and strength of H13MOD at higher tempering temperature(above570℃)are nearly the same as those of H13,but its toughness is higher than that of H13.Mo2C carbide is the main strengthening phase in H13MOD,which is attributed to the higher content of Mo.The quantity of VC eutectic carbides is reduced because of lower content of V in H13MOD,which plays an important role in enhancing the impact toughness of H13MOD.Under a certain strength condition,H13MOD steel can be used in the environment that higher toughness is required and the service life of die casting mold can be improved. | ZHOU Jian MA Dang-shen CHI Hong-xiao CHEN Zai-zhi LI Xiang-yang | 2013 | Journal of Iron and Steel Research(International)2013，20，9： | 25 |
| 3 | Major Technologies for Safe Construction of High Earth-Rockfill Dams显示文摘 | Hongqi Ma Fudong Chi | 2016 | Engineering2016，2，4： | 22 |
| 4 | Technical Progress on Researches for the Safety of High Concrete-Faced Rockfill Dams显示文摘The concrete-faced rockfill dam(CFRD) is an important dam type in the selection of high dams to be constructed in Western China,owing to its direct utilization of local materials,good adaptability,and distinct economic advantages.Over the past decades,China has gained successful experience in the construction of 200 m CFRDs,providing the necessary technical accumulation for the development of 250–300 m ultra-high CFRDs.This paper summarizes these successful experiences and analyzes the problems of a number of major 200 m CFRDs around the world.In addition,it discusses the key technologies and latest research progress regarding safety in the construction of 250–300 m ultra-high CFRDs,and suggests focuses and general ideas for future research. | Hongqi Ma Fudong Chi | 2016 | Engineering2016，2，3： | 19 |
| 5 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 6 | Circular RNA PIP5K1A promotes colon cancer development through inhibiting mi R-1273a显示文摘BACKGROUND Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1A’s role may help with the identification of novel diagnostic and therapeutic targets for colon cancer. AIM To investigate the status of circPIP5K1A in colon cancers and its effects on the modulation of cancer development. METHODS The expression level of circPIP5K1A in tissue and serum samples from colon cancer patients, as well as human colonic cancer cell lines was detected by realtime quantitative reverse transcription-polymerase chain reaction. Following the transfection of specifically synthesized small interfering RNA (siRNA) into colon cell lines, we used Hoechst staining assay to measure the ratio of cell death in the absence of circPIP5K1A. Moreover, we also used the Transwell assay to assess the migratory function of colon cells overexpressing circPIP5K1A. Additionally, we employed a series of bioinformatics prediction programs to predict the potential of circPIP5K1A-targeted miRNAs and mRNAs. The miR-1273a vector was constructed, and then transfected with or without circPIP5K1A vector into colon cancer cells. Afterwards, the expression of activator protein 1 (AP-1), interferon regulating factor 4 (IRF-4), caudal type homeobox 2 (CDX-2), and zinc finger of the cerebellum 1 (Zic-1) was detected by western blotting. RESULTS CircPIP5K1A was significantly upregulated in colon cancer tissue relative to their adjacent normal tissues. Knockdown of circPIP5K1A in colon cancer cells impaired cell viability and suppressed cell invasion and migration, while enforced expression of circPIP5K1A exhibited the opposite effects on cell migration. Bioinformatics prediction program predicted that the association of circPIP5K1A with miR-1273a, as well as AP-1, IRF-4, CDX-2, and Zic-1. Subsequent studies showed that overexpression of circPIP5K1A augmented the expression of AP-1 but attenuated the expression of IRF-4, CDX-2, and Zic-1. Reciprocally, overexpression of miR-1273a abrogated the oncogenic function of circPIP5K1A in colon cancers. CONCLUSION Overall, our data demonstrate the oncogenic role of circPIP5K1A-miR-1273a axis in regulation of colon cancer development, which provides a novel insights into colon cancer pathogenesis. | Qu Zhang Chi Zhang Jian-Xin Ma Hui Ren Yu Sun Jiao-Zhen Xu | 2019 | World Journal of Gastroenterology2019，25，35： | 18 |
| 7 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 8 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 9 | Marine Yeasts and Their Applications in Mariculture显示文摘The terrestrial yeasts have been receiving great attention in science and industry for over one hundred years because they can produce many kinds of bioactive substances. However, little is known about the bioactive substances of marine yeasts. In recent years, it has been found that marine yeasts have wide applications in mariculture and other fields. Therefore,marine yeasts, the bioactive substances from them and the applications of marine yeasts themselves and the bioactive substances they produced are reviewed in this paper. | CHI Zhenming LIU Zhiqiang GAO Lingmei GONG Fang MA Chunling WANG Xianghong LI Haifeng | 2006 | Journal of Ocean University of China2006，5，3： | 12 |
| 10 | Geochemical Characteristics and Geological Significance of Early Permian Baya'ertuhushuo Gabbro in South Great Xing'an Range显示文摘领域地质的调查和 geochemical 分析在南方伟人 Xing'an 在 Baya'ertuhushuo 斑粝岩上被执行范围。当以前想了,领域调查表明斑粝岩是 magmatic 侵入而非一间 ophiolite 套房的一个部件。标明日期的诱导地联合的血浆团光谱学(LA-ICP-MS ) U-Pb 显示的锆石激光脱离斑粝岩在 274275 妈,被形成就作为 Dashizhai 形成(P1d ) 的普遍暴烈的岩石,在学习区域的 monzogranites 和 miarolitic 碱长石花岗石。斑粝岩有在 47.23 wt% 之间的 SiO2 内容,分别地, 50.17 wt% ,高 MgO 和 FeOT 6.9511.29 满足 wt% 和 7.3212.24 wt% ,它在 SiO2-K2O 图属于 low-K tholeiitic 系列。使球粒状陨石正常化的稀土元素元素(REE ) 模式和斑粝岩的原始使披风正常化的蜘蛛图除了大离子亲石元素元素(LILE ) 的丰富类似于正常海中央理兹暗岩(N-MORB ) 的那些,例如 Rb, Ba 和 K。在踪迹元素构造的歧视的图,样品主要也在 situ Lu-Hf 同位素的分析在 N-MORB 领域,和锆石里被阴谋显示斑粝岩从弄空的披风发源。通过 geochemical 特征的合成研究和 Baya'ertuhushuo 斑粝岩的 petrogenesis ,在区域的 Dashizhai 形成和 granitoids 的暴烈的岩石,在 Xilinhot-Xiwuqi 区域的早二叠的 magmatism 在岩流圈 upwelling 的构造背景形成了,这被建议,它被 subducted 的打破离开引起Paleo亚洲的海洋平板。 | LIU Jianfeng CHI Xiaoguo ZHAO Zhi ZHANG Xingzhou MA Zhihong WANG Tiefu HU Zhaochu | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 12 |
| 11 | Adsorption of lead on multi-walled carbon nanotubes with different outer diameters and oxygen contents: Kinetics, isotherms and thermodynamics显示文摘The effects of different outer diameters and surface oxygen contents on the adsorption of heavy metals onto six types of multi-walled carbon nanotubes (MWCNTs) were investigated in an aqueous solution and lead was chosen as a model metal ion. The results indicated that the percentage removal and adsorption capacity of lead remarkably increased with decreasing outer diameter due to larger specific surface area (SSA). The SSA-normalized maximum adsorption capacity (qm /SSA) and SSA-normalized adsorption coefficient (Kd /SSA) were strongly positively correlated with surface oxygen content, implying that lead adsorption onto MWCNTs significantly increases with the rise of oxygen content and decreases with decreasing SSA. The calculated thermodynamic parameters indicated that adsorption of lead on MWCNTs was endothermic and spontaneous. When the oxygen content of MWCNTs increased from 2.0% to 5.9%, the standard free energy (△ G0 ) became more negative, which implied that the oxygenated functional groups increased the adsorption affinity of MWCNTs for lead. Through calculation of enthalpy (△ H0 ), G0 and free energy of adsorption (Ea ), lead adsorption onto MWCNTs was recognized as a chemisorption process. The chemical interaction between lead and the phenolic groups of MWCNTs could be one of the main adsorption mechanisms due to highly positive correlations between the phenolic groups and K d /SSA or q m /SSA. | Fei Yu Yanqing Wu Jie Ma Chi Zhang | 2013 | Journal of Environmental Sciences2013，25，1： | 11 |
| 12 | Current advances for bone regeneration based on tissue engineering strategies显示文摘Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration. | Rui Shi Yuelong Huang Chi Ma Chengai Wu Wei Tian | 2019 | Frontiers of Medicine2019，13，2： | 10 |
| 13 | Identification of a Resistance Gene bls1 to Bacterial Leaf Streak in Wild Rice Oryza rufipogon Griff显示文摘Bacterial leaf streak (BLS) of rice, caused by Xanthomonas oryzae pv. oryzicola (Xoc) is a worldwide destructive disease. Development of resistant varieties is considered to be one of the most effective and eco-friendly ways to control the disease. However, only a few genes/QTLs having resistance to BLS have been identified in rice until now. In the present study, we have identified and primarily mapped a BLS-resistance gene, bls1, from a rice line DP3, derived from the wild rice species Oryza rufipogon Griff. A BC2F2 (9311/DP3//9311) population was constructed to map BLS-resistance gene in the rice line DP3. The segregation of the resistant and susceptible plants in BC2F2 in 1:3 ratio (c2=0.009, c20.05, 1=3.84, P>0.05), suggested that a recessive gene confers BLS resistance in DP3. In bulked segregant analysis (BSA), two SSR markers RM8116 and RM584 were identified to be polymorphic in resistant and susceptible DNA bulks. For further mapping the resistance gene, six polymorphic markers around the target region were applied to analyze the genotypes of the BC2F2 individuals. As a result, the BLS-resistant gene, designated as bls1, was mapped in a 4.0-cM region flanked by RM587 and RM510 on chromosome 6. | HE Wen-ai HUANG Da-hui LI Rong-bai QIU Yong-fu SONG Jian-dong YANG Hai-ning ZHENG Jia-xing HUANG Yue-yue LI Xiao-qiong LIU Chi ZHANG Yue-xiong MA Zeng-feng YANG Yong | 2012 | Journal of Integrative Agriculture2012，11，6： | 9 |
| 14 | Catalytic oxidation of benzene over nanostructured porous Co_3O_4-CeO_2 composite catalysts显示文摘Mesostructured Co3O4-CeO2 composite was found to be an effective catalytic material for the complete oxidation of benzene. The Co3O4-CeO2 catalysts with different Co/Ce ratios (mol/mol) were prepared via the nanocasting method and the mesostructure was replicated from two-dimensional (2D) hexagonal SBA-15 and three-dimensional (3D) cubic KIT-6 silicas, respectively. All the obtained Co3O4-CeO2 catalysts exhibited the similar symmetry with the parent silicas and well ordered mesostructures. The Co3O4- CeO2 catalysts with 2D mesostructure showed lower catalytic activities than the corresponding 3D materials. The Co3O4-CeO2 catalyst nanocasted from KIT-6 and with the Co/Ce ratio of 16/1 possessed the best catalytic benzene oxidation activity due to larger quantities of surface hydroxyl groups and surface oxygenated species. The mesostructured Co3O4-CeO2 material thus shows great potential as a promising eco-environmental catalyst for benzene effective elimination. | Chunyan Ma Zhen Mu Chi He Peng Li Jinjun Li Zhengping Hao | 2011 | Journal of Environmental Sciences2011，23，12： | 9 |
| 15 | Extant primates and development of primatology in China: Publications, student training, and funding显示文摘China supports the richest non-human primate diversity in the northern hemisphere, providing an excellent opportunity for Chinese primatologists to take a leading role in advancing the study of primatology.Primatology in China began to flourish after 1979. To date, Chinese primatologists have published more than 1 000 papers in journals indexed by the Chinese Science Citation Database and the Web of Science Core Collection, and universities and academic institutions have trained 107 PhD students and 370 Masters students between 1984 and 2016. In total,the National Science Foundation of China has funded129 primate projects(RMB 71.7 million) supporting 59 researchers from 28 organizations. However, previous research has also shown obvious species bias.Rhinopithecus roxellana, Rhinopithecus bieti, and Macaca mulatta have received much greater research attention than other species. Researchers have also tended to continue to study the same species(55.2%)they studied during their Ph D training. To promote the development of primatology in China, we suggest(1)the need for a comprehensive primatology textbook written in Chinese,(2) continued training of more Ph D students, and(3) encouragement to study less well-known primate species. | Peng-Fei Fan Chi Ma | 2018 | Zoological Research2018，39，4： | 9 |
| 16 | The Optimization of Ultrasonic Extraction Process of Total Flavonoids from Rhodiola Crenulata by Response Surface Method显示文摘[Objectives]To study the optimal extraction process of total flavonoids in Rhodiola rosea L.,and further facilitate the development and utilization of Rhodiola rosea L. [Methods]With Rhodiola crenulata as raw material,ethanol as extractant,ultrasonic extraction as the extraction method,the single factor method was first used for preliminary investigation of effect of ethanol volume fraction,solid-liquid ratio,extraction temperature and extraction time on the flavonoids extraction rate,and then the Box-Behnken response surface method was used to optimize the extraction process of total flavonoids in R. crenulata. [Results] The optimal extraction conditions: ethanol concentration of 72%;solid-liquid ratio of 1∶ 43; extraction temperature of 66℃; extraction time of 50 min. Under these conditions,the extraction rate of total flavonoids from R. crenulata was 2. 591%. [Conclusions] The results showed that the method of response surface was reasonable and feasible for the optimization of ultrasonic extraction of total flavonoids from R. crenulata. | Xuedong GU Yajing SUN Changzhong MA Fumin CHI Lin YANG | 2017 | Medicinal Plant2017，8，6： | 9 |
| 17 | Microstructure and Mechanical Properties of Martensitic Stainless Steel 6Cr15MoV显示文摘Martensitic stainless steel containing Cr of 12% to 18% (mass percent) are common utilized in quenching and tempering processes for knife and cutlery steel. The properties obtained in these materials are significantly influenced by matrix composition after heat treatment, especially as Cr and C content. Comprehensive considered the hardness and corrosion resistance, a new type martensitic stainless steel 6Cr15MoV has been developed. The effect of heat treatment processes on microstructure and mechanical properties of 6Cr15MoV martensitic stainless steel is emphatically researched. Thermo-Calc software has been carried out to thermodynamic calculation; OM, SEM and TEM have been carried out to microstructure observation; hardness and impact toughness test have been carried out to evaluate the mechanical properties. Results show that the equilibrium carbide in 6Cr15MoV steel is M23C6 carbide, and the M23C6 carbides finely distributed in annealed microstructure. 6Cr15MoV martensitic stainless steel has a wider quenching temperature range, the hardness value of steel 6Cr15MoV can reach to HRC 60.8 to HRC 61.6 when quenched at 1 060 to 1 100 ℃. Finely distributed carbides will exist in quenched microstructure, and effectively inhabit the growth of austenite grain. With the increasing of quenching temperature, the volume fraction of undissolved carbides will decrease. The excellent comprehensive mechanical properties can be obtained by quenched at 1 060 to 1 100 ℃ with tempered at 100 to 150 ℃, and it is mainly due to the high carbon martensite and fine grain size. At these temperature ranges, the hardness will retain about HRC 59.2 to HRC 61.6 and the Charpy U-notch impact toughness will retain about 17.3 to 20 J. A lot of M23C6 carbides precipitated from martensite matrix, at the same time along the boundaries of martensite lathes which leading to the decrease of impact toughness when tempered at 500 to 540 ℃. The M3C precipitants also existed in the martensite matrix of test steel after tempered at 500 ℃, and the mean size of M3C precipitates is bigger than that of M23C6 precipitates. | MA Dang-shen1, CHI Hong-xiao1,2, ZHOU Jian1, YONG Qi-long1,2 (1. Institute for Structural Materials, Central Iron and Steel Research Institute, Beijing 100081, China 2. Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, Yunnan, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，3： | 8 |
| 18 | Association of emergency room visits for respiratory diseases with sources of ambient PM2.5显示文摘Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory diseases.Few studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory diseases.Source apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease ERVs.The association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)increase.We found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),respectively.The estimated effects of PM2.5 changed little after adjusting for different air pollutants.Six primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare. | Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo | 2019 | Journal of Environmental Sciences2019，31，12： | 8 |
| 19 | “Three Methods and Three Points” regulates p38 mitogen-activated protein kinase in the dorsal horn of the spinal cord in a rat model of sciatic nerve injury显示文摘Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions and indices of the spinal dorsal horn using the Dian, Bo, and Rou method in Yinmen(BL37), Yanglingquan(GB34), and Weizhong(BL40). Treatment prevents muscle atrophy, protects spinal cord neurons, and promotes sciatic nerve repair. The mechanisms of action of tuina for treating peripheral nerve injury remain poorly understood. This study established rat models of sciatic nerve injury using the crushing method. Rats received Chinese tuina in accordance with the principle of 'Three Methods and Three Points,' once daily for 20 days. Tuina intervention reduced paw withdrawal latency and improved wet weight of the gastrocnemius muscle, as well as promoting morphological recovery of sciatic nerve fibers, Schwann cells, and axons. The protein expression levels of phospho-p38 mitogen-activated protein kinase, tumor necrosis factor-α, and interleukin-1β also decreased. These findings indicate that 'Three Methods and Three Points' promoted morphological recovery and improved behavior of rats with peripheral nerve injury. | Xin Guo Tian-yuan Yu Wong Steven Wen-duan Jia Chi Ma Yan-hong Tao Chao Yang Tao-tao Lv Shuai Wu Meng-qian Lu Jia-li Liu | 2016 | Neural Regeneration Research2016，11，12： | 7 |
| 20 | Prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases显示文摘BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced CRC.Hepatectomy is the gold standard treatment for colorectal liver metastases.For patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival time.AIM To explore the prognostic factors and treatments of liver metastases of CRC.METHODS A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March 2011.According to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were analyzed.The Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate analysis.RESULTS The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,respectively.The Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great vessels.The results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 mo.The drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resection was better than that of patients using other treatments(20.6 mo)(P<0.05).CONCLUSION Patients with a low degree of primary tumor differentiation,multiple liver metastases(number of tumors>4),and maximum diameter of liver metastases>5 cm have a poor prognosis.Among drug therapy,intervention,ablation,and surgical treatment options,surgical treatment is the first choice for liver metastases.When liver metastases are close to great vessels,surgical treatment is significantly better than drug therapy,intervention,and ablation alone. | Zuo-Hong Ma Yong-Peng Wang Wen-Heng Zheng Ji Ma Xue Bai Yong Zhang Yuan-He Wang Da Chi Xi-Bo Fu Xiang-Dong Hua | 2020 | World Journal of Gastrointestinal Oncology2020，12，10： | 7 |
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