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| 1 | 白塞病相关自身抗原Kinectin的表达型cDNA文库筛选与鉴定显示文摘目的研究白塞病患者血循环中的自身抗体及其针对的细胞内靶抗原。方法应用免疫印迹-化学发光法对39例白塞病患者血清进行初步研究,以含有高滴度抗体的患者血清作为“探针”免疫筛选表达型!ZAP噬菌体cDNA文库并鉴定候选克隆,通过真核转录、翻译以及免疫沉淀实验分析阳性克隆表达产物的抗原性。结果文库筛选获得6个独立候选克隆,均为人Kinectin部分全长cDNA,以其中最大克隆的基因表达产物为抗原基质的免疫沉淀研究显示,23.1%(9/39)的白塞病患者血清呈阳性反应,正常人以及系统性红斑狼疮、干燥综合征患者对照阴性。结论Kinectin是白塞病相关自身靶抗原;抗Kinectin抗体与白塞病免疫发病机制的关系值得深入探索,抗体可能对疾病具有潜在血清学诊断价值。 | 陆瑜 叶萍 陈顺乐 顾越英 Eng M.Tan Edward KL Chan | 2005 | 中华风湿病学杂志2005，9，10： | 5 |
| 2 | Hydrodynamic Coefficients for a 3-D Uniform Flexible Barge UsingWeakly Compressible Smoothed Particle Hydrodynamics显示文摘The numerical modelling of the interactions between water waves and floating structures is significant for different areas of the marine sector, especially seakeeping and prediction of wave-induced loads. Seakeeping analysis involving severe flow fluctuations is still quite challenging even for the conventional RANS method. Particle method has been viewed as alternative for such analysis especially those involving deformable boundary, wave breaking and fluid fragmentation around hull shapes. In this paper, the weakly compressible smoothed particle hydrodynamics(WCSPH), a fully Lagrangian particle method, is applied to simulate the symmetric radiation problem for a stationary barge treated as a flexible body. This is carried out by imposing prescribed forced simple harmonic oscillations in heave, pitch and the two-and three-node distortion modes. The resultant,radiation force predictions, namely added mass and fluid damping coefficients, are compared with results from 3-D potential flow boundary element method and 3-D RANS CFD predictions, in order to verify the adopted modelling techniques for WCSPH.WCSPH were found to be in agreement with most results and could predict the fluid actions equally well in most cases. | Muhammad Zahir Ramli P.Temarel M.Tan | 2018 | Journal of Marine Science and Application2018，17，3： | 4 |
| 3 | 白塞病相关新自身抗原的初步免疫学分析显示文摘为探讨白塞病是否存在特异性循环自身抗体,我们应用免疫印迹结合免疫沉淀技术对39例该病患者血清进行了初步筛查。结果发现,分别有8份(20.5%)、9份(23.1%)血清识别相对分子质量约为100 000、50 000的细胞内性质不明成分,其中4份标本(10.3%)与上述两种蛋白反应;在免疫沉淀分析中,15份血清(38.5%)可主要沉淀细胞中相对分子质量约为200 000、160 000、120 000、100 000的某些蛋白,部分免疫印迹阳性的血清其免疫沉淀分析也呈阳性结果。研究提示白塞病血清中可能存在作用于细胞内未知抗原的IgG型自身抗体,值得深入探索,以澄清靶抗原的性质,明确相应自身抗体对白塞病的特异性、血清学诊断价值及其可能的免疫致病机制。 | 陆瑜 叶萍 陈顺乐 Eng M.Tan EdwardK.L.Chan | 2002 | 上海免疫学杂志2002，22，4： | 3 |
| 4 | An experimental and numerical study of chemically enhanced water alternating gas injection显示文摘In this work, an experimental study combined with numerical simulation was conducted to investigate the potential of chemically enhanced water alternating gas(CWAG) injection as a new enhanced oil recovery method.The unique feature of this new method is that it uses alkaline, surfactant, and polymer additives as a chemical slug which is injected during the water alternating gas(WAG) process to reduce the interfacial tension(IFT) and simultaneously improve the mobility ratio. In essence, the proposed CWAG process involves a combination of chemical flooding and immiscible carbon dioxide(CO2)injection and helps in IFT reduction, water blocking reduction, mobility control, oil swelling, and oil viscosity reduction due to CO2 dissolution. Its performance was compared with the conventional immiscible water alternating gas(I-WAG) flooding. Oil recovery utilizing CWAG was better by 26 % of the remaining oil in place after waterflooding compared to the recovery using WAG conducted under similar conditions. The coreflood data(cumulative oil and water production) were history matched via a commercial simulator by adjusting the relative permeability curves and assigning the values of the rock and fluid properties such as porosity, permeability, and the experimentally determined IFT data. History matching of the coreflood model helped us optimize the experiments and was useful in determining the importance of the parameters influencing sweep efficiency in the CWAG process. The effectiveness of the CWAG process in providing enhancement of displacement efficiency is evident in the oil recovery and pressure response observed in the coreflood. The results of sensitivity analysis on CWAG slug patterns show that the alkaline–surfactant–polymer injection is more beneficial after CO2 slug injection due to oil swelling and viscosity reduction. The CO2 slug size analysis shows that there is an optimum CO2 slug size,around 25 % pore volume which leads to a maximum oil recovery in the CWAG process. This study shows that the ultralow IFT system, i.e., IFT equaling 10-2or 10-3m N/m, is a very important parameter in CWAG process since the water blocking effect can be minimized. | Saeed Majidaie Mustafa Onur Isa M.Tan | 2015 | Petroleum Science2015，12，3： | 2 |
| 5 | Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor‐associated antigens显示文摘 | Fu‐DongShi Jian‐YingZhang DaorongLiu AnnRearden MaxElliot DanNachtsheim TracyDaniels Carlos A.Casiano Mary JoHeeb Edward K.L.Chan Eng M.Tan | 2005 | Prostate2005，，3： | 1 |
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