|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 九价人乳头瘤病毒疫苗的保护效力、免疫原性和安全性:亚洲人群亚组分析显示文摘预防性人乳头瘤病毒(HPV)疫苗接种可以降低HPV相关疾病负担。过去十年内上市的二价HPV疫苗(HPV16、18)和四价疫苗(HPV6、11、16、18)可以在全世界范围内(包括亚州)预防约70%的宫颈癌,同时四价疫苗还可以预防约90%的生殖器疣。 | S.M.Garland P.Pitisuttithum H.Y.S.Ngan C.-H.Cho C.-Y.Lee C.-A.Chen Y.C.Yang T.-Y.Chu N.-F.Twu R.Samakoses Y.Takeuchi T.H.Cheung S.C.Kim L.-M.Huang B.-G.Kim Y.-T.Kim K.-H.Kim Y.-S.Song S.Lalwani J.-H.Kang M.Sakamoto H.-S.Ryu N.Bhatla H.Yoshikawa M.C.Ellison S.R.Han E.Moeller S.Murata M.Ritter M.Sawata C.Shields A.Walia G.Perez A.Luxembourg 魏丽惠 | 2018 | 中国病毒病杂志2018，8，4： | 7 |
| 2 | A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure显示文摘5q-syndrome is a distinct form of myelodysplastic syndrome(MDS) where a deletion on chromosome 5 is the underlying cause.MDS is characterized by bone marrow failures,including macrocytic anemia.Genetic mapping and studies using various models support the notion that ribosomal protein S14(RPS14) is the candidate gene for the erythroid failure.Targeted disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal proteins.However,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment option.To better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 gene.This model mirrors the anemic phenotype seen in 5q-syndrome.Moreover,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes p53-dependent.Finally,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype. | Jason Ear Jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin | 2016 | Journal of Genetics and Genomics2016，43，5： | 5 |
| 3 | Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen显示文摘 | M.Sakamoto T.Ueno T.Nakamura R.Sakata O.Hasimoto T.Torimura M.Sata | 2005 | European Journal of Clinical Investigation2005，，3： | 1 |
| 4 | Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen显示文摘 | M.Sakamoto T.Ueno T.Nakamura R.Sakata O.Hasimoto T.Torimura M.Sata | 2005 | European Journal of Clinical Investigation2005，，3： | 1 |
| 5 | Fine mapping and DNA fiber FISH analysis locates the tobamovirus resistance gene L3 of Capsicum chinense in a 400-kb region of R-like genes cluster embedded in highly repetitive sequences显示文摘 | Tomita R J.Murai Y.Miura H.Ishihara S.Liu Y.Kubotera A.Honda R.Hatta T.Kuroda H.Hamada M.Sakamoto I.Munemura O.Nunomura K.Ishikawa Y.Genda S.Kawasaki K.Suzuki K.Meksem and K.Kobayashi | | 0，，： | 1 |
| 6 | Two Dimensional Density FlUCtuation Measurements During the Non-Inductive Current Ramp-up Phase in the Compact Plasma Wall Interaction Experimental Device CPD显示文摘密度变化的二维的结构在电流期间被检验跳阶段,从户外磁场显示一个变化到关上的。斜面起来垂直地在光滑的电流期间分阶段执行 LiI 紧张表演的二维的轮廓排列,与磁性的表面一致。在变化点在我 p 斜面起来, LiI 紧张轮廓在观察政体然后突然变得扁平一个陡峭的坡度和更高的紧张政体在垂直方向被形成。这更高的紧张对应于 LiI 波形的爆炸。根据在轮廓的这些变化,它被发现那,在在 LiI 的爆炸附近的± 1 ms 以内,有长波长的协调波浪很快种的低频率。有另外的信号的关系(磁性的流动和微波迷路的力量) 在磁性的配置和事件电磁波的模式变换关于拓扑的变化被讨论。 | H.ZUSHI T.RYOUKAI K.KIKUKAWA T.MORISAKI R.BHATTACHARYAY T.YOSHINAGA K.HANADA T.SAKIMURA H.IDEI K.DONO N.NISHINO H.HONMA S.TASHIMA T.MUTOH S.KUBO K.NAGASAKI M.SAKAMOTO Y.NAKASHIMA Y.HIGASHIZONO K.N.SATO K.NAKAMURA M.HASEGAWA S.KAWASAKI H.NAKASHIMA A.HIGASHIJIMA | 2009 | Plasma Science and Technology2009，11，4： | 0 |
| 7 | Magnetic Sensorless Sensing of Plasma Position in the Superconducting Tokamak HT-7显示文摘Magnetic sensorless sensing experiments of the plasma horizontal position have been carried out in the superconducting tokamak HT-7. The horizontal position is calculated from the vertical field coil current and voltage without using signals of magnetic probes placed nearby a plasma. The calculations are focused on the ripple frequency component of the power supply.There is no drift problem with the time integration of magnetic probe signals. The error of the derived plasma position is lower than 2% of the plasma minor radius. | K.Nakamura Z.S.Ji B.Shen P.J.Qin S.Itoh K.Hanada M.Sakamoto E.Jotaki M.Hasegawa A.Iyomasa S.Kawasaki H.Nakashima | 2004 | Plasma Science and Technology2004，6，5： | 0 |
| 8 | Magnetic Sensorless Control of Plasma Position and Shape in a Tokamak显示文摘Magnetic sensorless sensing and control experiments with the plasma horizontalposition have been carried out in the superconducting tokamak HT-7.The sensing is made tofocus on the ripple,frequency component of the power supply with thyristor and directly from themwithout time integration.There is no drift problem with the integrator of magnetic sensors.Twokinds of control experiments have been carried out:to keep the position constant and swing theposition in a triangular waveform.And magnetic sensorless sensing of plasma shape is discussed. | K.NAKAMURA 罗家融 王华忠 季振山 王华 王枫 齐娜 K.N.SATO K.HANADA M.SAKAMOTO H.IDEI M.HASEGAWA S.KAWASAKI H.NAKASHIMA A.HIGASHIJIMA | 2006 | Plasma Science and Technology2006，8，1： | 0 |
| 9 | Progress in Physics and Technology Developments for the Modification of JT-60显示文摘Recent progress in the physics and engineering design study for the modification programme of JT-60 is presented.In order to achieve a steady state high-β plasma operation,which is the dominant issue of this programme,physics design for the MHD control and the stability analysis is investigated.Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme. | H.Tamai M.Matsukawa G.Kurita N.Hayashi K.Urata Y.M.Miura K.Kizu K.Tsuchiya A.Morioka Y.Kudo S.Sakurai K.Masaki T.Suzuki M.Takechi Y.Kamada A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-Iio S.Itoh M.Katsurai M.Kikuchi A.Kohyama H.Kubo M.Kuriyama M.Matsuoka Y.Miura N.Miya T.Mizuuchi K.Nagasaki H.Ninomiya N.Nishino Y.Ogawa K.Okano T.Ozeki M.Saigusa M.Sakamoto M.Satoh M.Shimada R.Shimada M.Shimizu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yamamoto K.Yatsu K.Yoshikawa | 2004 | Plasma Science and Technology2004，6，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员