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| 1 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘The miR-15/107 family comprises a group of 10 paralogous microRNAs(miRNAs),sharing a 50AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations(enriched for cortical neurons,astrocytes and microglia,respectively).In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system(CNS).In addition to mature miRNAs,we also examined the expression of precursors(pri-miRNAs).Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. | Wang-Xia Wang Robert J.Danaher Craig S.Miller Joseph R.Berger Vega G.Nubia Bernard S.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson | 2014 | Genomics, Proteomics & Bioinformatics2014，12，1： | 9 |
| 2 | Effectiveness of L2 Instruction: A Research Synthesis and Quantitative Meta‐analysis显示文摘 | John M.Norris LourdesOrtega | 2008 | Language Learning2008，，3： | 2 |
| 3 | Effectiveness of L2 Instruction: A Research Synthesis and Quantitative Meta‐analysis显示文摘 | John M.Norris LourdesOrtega | 2008 | Language Learning2008，，3： | 1 |
| 4 | Productivity Growth,Technical Progress,and Efficiency Changes in Industrial Countries显示文摘 | Fre R S.Grosskopf M.Norris Z.Zhang | | 0，，84： | 1 |
| 5 | Productivity Growth,Technical Progress and Efficiency Change in Industrialized Countries显示文摘 | Fare Rolf S.Grosskopf M.Norris Z.Zhang | | 0，，84： | 1 |
| 6 | Productivity Growth,Technical Progress,and Efficiency Change in Industrialized Countries显示文摘 | R.Fare S.Grosskopf M.Norris Zhang Z | | 0，，84： | 1 |
| 7 | Effectiveness of L2 Instruction: A Research Synthesis and Quantitative Meta‐analysis显示文摘 | John M.Norris LourdesOrtega | 2008 | Language Learning2008，，3： | 1 |
| 8 | Productivity Growth,Technical Progress,and Efficiency Change in Industrialized Countries显示文摘 | R.F(a)re S.Grosskopf M.Norris Zhang Z | | 0，，01： | 1 |
| 9 | Productivity Growth,Technical Progress,and Efficiency Change in Industrialized Countries显示文摘 | F(a)re R S.Grosskopf M.Norris Z.Zhang | | 0，，： | 1 |
| 10 | Association of PNPLA3 with non‐alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study显示文摘 | Lynne E.Wagenknecht Nicholette D.Palmer Donald W.Bowden Jerome I.Rotter Jill M.Norris JulieZiegler Yii‐Der I.Chen StevenHaffner AnnScherzinger Carl D.Langefeld | 2011 | Liver International2011，，3： | 1 |
| 11 | Does Type of Instruction Make a Difference? Substantive Findings From a Meta‐analytic Review显示文摘 | John M.Norris LourdesOrtega | 2005 | Language Learning2005，，： | 1 |
| 12 | Association of PNPLA3 with non‐alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study显示文摘 | Lynne E.Wagenknecht Nicholette D.Palmer Donald W.Bowden Jerome I.Rotter Jill M.Norris JulieZiegler Yii‐Der I.Chen StevenHaffner AnnScherzinger Carl D.Langefeld | 2011 | Liver International2011，，3： | 1 |
| 13 | Productivity Growth Technical Progress and Efficiency Change in Industrialized Countries显示文摘 | R.F(a)re S.Grosskopf M.Norris | | 0，，01： | 1 |
| 14 | 使知识服务在高等教育中发挥作用显示文摘我们在2003年的《EDUCAUSE Reviw》中发表了“知识共享的革命”(A Revolution in Knowledge Sharing)一文。文中指出,许多正在形成的以知识为核心的行为方式和趋势可能会创造新的价值,尤其是在高等教育中。这些行为方式和趋势有: | Donald M.Norris 李忠霞(编译) 初景利(校) | 2006 | 图书情报工作动态2006，，10： | 0 |
| 15 | Mechanism-driven strategies for prevention of rheumatoid arthritis显示文摘In seropositive rheumatoid arthritis(RA),the onset of clinically apparent inflammatory arthritis(IA)is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antibodies to citrullinated protein antigens(ACPA)and rheumatoid factor.This period before clinical IA can be designated preclinical RA in those individuals who have progressed to a clinical diagnosis of RA,and an“at‐risk”status in those who have not developed IA but exhibit predictive biomarkers of future clinical RA.With the goal of developing RA prevention strategies,studies have characterized immune phenotypes of preclinical RA/at-risk states.From these studies,a model has emerged wherein mucosal inflammation and dysbiosis may lead first to local autoantibody production,which should normally be transient,but instead is followed by a systemic spread of the autoimmunity as manifested by serum autoantibody elevations,ultimately driving the development of clinically identified joint inflammation.This model can be envisioned as the progression of disease development through serial“checkpoints”that in principle should constrain or resolve autoimmunity;however,instead,the checkpoints“fail”and clinical RA develops.Herein we review the immune processes that are likely to be present at each step and the potential therapeutic strategies that could be envisioned to delay,diminish,halt,or even reverse the progression to clinical RA.Notably,these prevention strategies could utilize existing therapies approved for clinical RA,therapies approved for other diseases that target relevant pathways in the preclinical/at-risk state,or approaches that target novel pathways. | V.Michael Holers Kristine A.Kuhn M.Kristen Demoruelle Jill M.Norris Gary S.Firestein Eddie A.James William H.Robinson Jane H.Buckner Kevin D.Deane | 2022 | Rheumatology & Autoimmunity2022，2，3： | 0 |
| 16 | 采用防垢技术保持压裂效果显示文摘支撑式水力压裂是油井增产的重要措施之一。支撑剂填充的裂缝内结垢会使压裂效果大打折扣 ,特别是在水驱开发的油田需要一种更有效的防垢手段。本文介绍了防垢浸透式支撑剂 (SIIP) | M.Norris 吕薇 高立新 赵进 | 2002 | 国外油田工程2002，18，6： | 0 |
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