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| 1 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
| 2 | 法证披露模型:应当向法证专家披露什么和法证专家应当披露什么?显示文摘法律上的披露问题主要集中在检控方向辩护方提供或者隐瞒了哪些证据。在本文中,我们将披露的概念扩展到更广泛的情境下,在这种情境下,披露失误可能导致误判。我们引入了一个概念模型,即“法证信息披露”,它涉及哪些信息应该披露给法证检验人员,以及法证检验人员应当披露哪些信息。本文全面概述了四类利益相关者的动态交互:法证服务、调查、法律和外部利益相关者。我们通过五个问题讨论了法证信息披露模式的有效实施,即如果要向法证检验人员或者由法证检验人员提供最好的信息,以提高法证决策质素,并尽量减少偏差,则什么时候进行披露?披露什么?如何披露?向谁披露?为什么披露? | 王进喜(译) | 2020 | 证据科学2020，28，1： | 3 |
| 3 | Cryptosporidium andersoni n. sp. (Apicomplexa: Cryptosporiidae) from Cattle, Bos taurus显示文摘 | DAVID S.LINDSAY STEVE J.UPTON DOUGLAS S.OWENS UNA M.MORGAN JAN R.MEAD BYRON L.BLAGBURN | 2005 | Journal of Eukaryotic Microbiology2005，，1： | 2 |
| 4 | Cryptosporidium hominis n. sp. (Apicomplexa: Cryptosporidiidae) from Homo sapiens显示文摘 | UNA M.MORGAN‐RYAN ABBIEFALL LUCY A.WARD NAWALHIJJAWI IRSHADSULAIMAN RONALDPAYER R. C. ANDREWTHOMPSON M.OLSON ALTAFLAL LIHUAXIAO | 2005 | Journal of Eukaryotic Microbiology2005，，6： | 1 |
| 5 | The impact of chronic urticaria on the quality of life显示文摘 | B.F.O’DONNELL F.LAWLOR J.SIMPSON M.MORGAN M.W.GREAVES | 2008 | British Journal of Dermatology2008，，2： | 1 |
| 6 | Relationship-Based Competitive Advantage显示文摘 | Robert M.Morgan Shelby Hunt | | 0，，： | 1 |
| 7 | Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series显示文摘Objective:To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(TP5)on prostate cancer pathological features and biochemical recurrence at our large single institution.Methods:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;TP5 was reported in 159 cases(8.1%).Men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without TP5,and histopathological features were compared.Multivariate analyses were conducted to assess the impact on TP5 on biochemical-free survival(BFS).Results:Tumors possessing GS 3+4 with TP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(TD)than GS 3+4 alone.GS 3+4 with TP5 was also associated with positive surgical margins(SM),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical significance.GS 4+3 with TP5 more commonly presented with EPE,positive SM,SVI,and greater TD and pre-operative PSA level than GS 4+3 alone.In multivariate analysis,Gleason score,EPE,and TP5 were overall independent risk factors for PSA recurrence in this cohort.Additionally,GS 4+3 with TP5 was associated with shorter time to recurrence versus GS 4+3 alone.Conclusion:Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be standardized.Further studies are needed to evaluate the role of tertiary patterns in prognostic models. | Zachary B.Koloff Daniel A.Hamstra John T.Wei Jeffrey S.Montgomery Scott A.Tomlins Angela J.Wu Todd M.Morgan Javed Siddiqui Kellie Paich Arul M.Chinnaiyan Felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju Brent K.Hollenbeck David C.Miller Ganesh S.Palapattu Rohit Mehra | 2015 | Asian Journal of Urology2015，2，1： | 1 |
| 8 | The Role of Existing Knowledge in New Product Innovativeness and Performance显示文摘 | Beverly K.Brockman Robert M.Morgan | 2003 | Decision Sciences2003，，2： | 1 |
| 9 | 冷冻喷丸修边的功能及其不足显示文摘冷冻高速喷丸修边是橡胶工业中采用的一种将飞边从橡胶模压制品上去掉的工艺。该工艺采用各种组合的液氮,高速旋转和介质(喷丸)将飞边去掉,是一种高精度,经济和有效的方法(见图1)。 | Stacy M.Morgan 杨钧 | 1999 | 橡胶参考资料1999，29，9： | 1 |
| 10 | The human and canine TERT promoters function equivalently in human and canine cells显示文摘 | M. L.Arendt L.Nasir I. M.Morgan | 2010 | Veterinary and Comparative Oncology2010，，4： | 1 |
| 11 | GBT L-波段高灵敏度19单元双极化致冷相控阵馈源显示文摘作为格林班克射电望远镜(GBT Green Bank Telescope)L波段焦平面阵计划(FLAG,Focal L-band Array for the GBT)的一部分,GBT的Robert开发了1种新的1.4 GHz、19单元双极化致冷相控阵馈源(PAF Phased-Array Feed)天文接收机,用校准射电源调试观测的数据表明,该接收机是迄今为止所有已报道PAF接收机中用口径效率(η)归一化的波束形成系统噪声温度(T_(sys))最低的。在1350 MHz附近测量的视轴方向波束的T_(sys)/η为25.4±2.5K,这个测量值与目前GBT使用的1.4GHz单馈源致冷接收机的性能相当,相比于视轴方向的T_(sys)/η值,在偏离视轴约4'(Nyquist奈奎斯特采样要求)和8'时的T_(sys)/η分别降低了1%和20%。与单波束系统相比,7波束PAF馈源的巡天速度分别约增加了2.1和7倍,并与观测应用有关。测量的性能,不论是频率和偏离视轴的值,与PAF馈源严格的电磁模型预计值一致。通过对脉冲星B0329+54和扩展HII区域-玫瑰星云的观测,证明了该接收机在天文观测中的实用性。通过使用新的PAF馈源,增强了巡天速度,将使GBT能够开展令人兴奋的新的科学观测,如更有效地观测弥散、星系流入的中性氢辐射以及搜索快速射电暴。 | D.Anish Roshi W.Shillue B.Simon K.F.Warnick B.Jeffs D.J.Pisano R.Prestage S.White J.R.Fisher M.Morgan R.Black M.Burnett J.Diao M.Ruzindana Vvan Tonder L.Hawkins P.MarganiarT T.Chamberlin J.Ray N.M.Pingel K.Rajwade D.R.Lorimer A.Rane J.Castro W.Groves L.Jensen J.D.Nelson T.Boyd A.J.Beasley | 2021 | 测控与通信2021，45，4： | 0 |
| 12 | GBTL-波段高灵敏度19单元双极化致冷相控阵馈源显示文摘作为格林班克射电望远镜(GBT Green Bank Telescope)L波段焦平面阵计划(FLAG,Focal L-band Array for the GBT)的一部分,GBT的Robert开发了1种新的1.4 GHz、19单元双极化致冷相控阵馈源(PAF Phased-Array Feed)天文接收机,用校准射电源调试观测的数据表明,该接收机是迄今为止所有已报道PAF接收机中用口径效率(Ti)归一化的波束形成系统噪声温度(Tsys)最低的。在1350 MHz附近测量的视轴方向波束的Tsys/ii为25.4±2.5K,这个测量值与目前GBT使用的1.4GHz单馈源致冷接收机的性能相当,相比于视轴方向的Tsys/η值,在偏离视轴约4″(Nyquist奈奎斯特采样要求)和8'时的Tsys/η分别降低了1%和20%。与单波束系统相比,7波束PAF馈源的巡天速度分别约增加了2.1和7倍,并与观測应用有关。测量的性能,不论是频率和偏离视轴的值,与PAF馈源严格的电磁模型预计值一致。通过对脉冲星B0329+54和扩展H Ⅱ区域-玫瑰星云的观测,证明了该接收机在天文观測中的实用性。通过使用新的PAF馈源,增强了巡天速度,将使GBT能够开展令人兴奋的新的科学观测,如更有效地观測弥散、星系流入的中性氢福射以及搜索快速射电暴。 | D.Anish Roshi W.Shillue B.Simon K.F.Warnick B.Jeffs D.J.Pisano R.Prestage S.White J.R.Fisher M.Morgan R.Black M.Burnett J.Diao M.Ruzindana V.van Tonder L.Hawkins P.Marganian T.Chamberlin J.Ray N.M.Pingel K.Rajwade D.R.Lorimer A.Rane J.Castro W.Groves L.Jensen J.D.Nelson T.Boyd A.J.Beasley 段玉虎(译) | 2022 | 测控与通信2022，46，1： | 0 |
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