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| 1 | Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit显示文摘Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbidity. We developed a rat model which allows the testing of different cell applications, i.e., mesenchymal stem cells, to improve nerve regeneration in vivo. To mimic inaccurate alignment of autologous nerve grafts with the injured nerve, a 20 mm portion of the sciatic nerve was excised, and sutured back in place in reversed direction. To validate the feasibility of our novel model, a fibrin gel conduit containing autologous undifferentiated adipose-derived stem cells was applied around the coaptation sites and compared to autologous nerve grafts. After evaluating sciatic nerve function for 16 weeks postoperatively, animals were sacrificed, and gastrocnemius muscle weight was determined along with morphological parameters(g-ratio, axon density & diameter) of regenerating axons. Interestingly, the addition of undifferentiated adipose-derived stem cells resulted in a significantly improved re-myelination, axon ingrowth and functional outcome, when compared to animals without a cell seeded conduit. The presented model thus displays several intriguing features: it imitates a certain mismatch in size, distribution and orientation of axons within the nerve coaptation site. The fibrin conduit itself allows for an easy application of cells and, as a true critical-size defect model, any observed improvement relates directly to the performed intervention. Since fibrin and adipose-derived stem cells have been approved for human applications, the technique can theoretically be performed on humans. Thus, we suggest that the model is a powerful tool to investigate cell mediated assistance of peripheral nerve regeneration. | Maximilian M.Saller Rosa-Eva Huettl Julius M.Mayer Annette Feuchtinger Christian Krug Thomas Holzbach Elias Volkmer | 2018 | Neural Regeneration Research2018，13，5： | 4 |
| 2 | Rutherford backscattering from layered structures beyond the single scattering model显示文摘 | W.ECKSTEIN M.MAYER | | 0，，： | 1 |
| 3 | Role of ultrasonographically guided fine‐needle aspiration cytology in the diagnosis of infected pancreatic necrosis显示文摘 | B.Rau U.Pralle J. M.Mayer H. G.Beger | 2003 | Br J Surg2003，，2： | 1 |
| 4 | A TRICKLE‐DOWN MODEL OF ABUSIVE SUPERVISION显示文摘 | MARY BARDESMAWRITZ DAVID M.MAYER JENNY M.HOOBLER SANDY J.WAYNE SOPHIA V.MARINOVA | 2012 | Personnel Psychology2012，，2： | 1 |
| 5 | Increased Benthic Algal Primary Production in Response to the Invasive Zebra Mussel (Dreissena polymorpha) in a Productive Ecosystem,Oneida Lake,New York显示文摘Increased water clarity associated with zebra mussel (Dreissena polymorpha) populations may favor benthic algal primary production in freshwater systems previously dominated by pelagic phytoplankton production.While zebra mussel-mediated water clarity effects on benthic primary production have been implicated in published reports,few production estimates are available.This study estimates benthic primary production in Oneida Lake,NY before and after zebra mussel invasion (1992),using measured photosynthetic parameters (PmBax,αB and β) from sampled benthic algal communities.In the summers of 2003 and 2004,primary production was measured as O2 evolution from algal communities on hard (cobble) and soft (sediment) substrate from several depths.We also backcast estimates of benthic primary production from measurements of light penetration since 1975.Estimates of whole-lake epipelic and epilithic algal primary production showed a significant (4%) increase and exhibited significantly less interannual variability subsequent to the establishment of zebra mussels.We applied our model to two lakes of differing trophic status; the model significantly overestimated benthic primary production in a hypereutrophic lake,but there was no significant difference between the actual and predicted primary production values in the oligotrophic lake.The hypereutrophic lake had higher zebra mussel densities than Oneida (224 vs.41 per sample respectively).Though total community respiration (measured in total darkness) was factored into our model predictions of production,our model may need modification when heterotrophic respiration is a large portion of total community metabolism. | Rebecca K.Cecala Christine M.Mayer Kimberly L.Schulz Edward L.Mills | 2008 | Journal of Integrative Plant Biology2008，50，11： | 0 |
| 6 | Hypoxic pre-conditioned adipose-derived stem/progenitor cells embedded in fibrin conduits promote peripheral nerve regeneration in a sciatic nerve graft model显示文摘Recent results emphasize the supportive effects of adipose-derived multipotent stem/progenitor cells(ADSPCs)in peripheral nerve recovery.Cultivation under hypoxia is considered to enhance the release of the regenerative potential of ADSPCs.This study aimed to examine whether peripheral nerve regeneration in a rat model of autologous sciatic nerve graft benefits from an additional custom-made fibrin conduit seeded with hypoxic pre-conditioned(2%oxygen for 72 hours)autologous ADSPCs(n=9).This treatment mode was compared with three others:fibrin conduit seeded with ADSPCs cultivated under normoxic conditions(n=9);non-cell-carrying conduit(n=9);and nerve autograft only(n=9).A 16-week follow-up included functional testing(sciatic functional index and static sciatic index)as well as postmortem muscle mass analyses and morphometric nerve evaluations(histology,g-ratio,axon density,and diameter).At 8 weeks,the hypoxic pre-conditioned group achieved significantly higher sciatic functional index/static sciatic index scores than the other three groups,indicating faster functional regeneration.Furthermore,histologic evaluation showed significantly increased axon outgrowth/branching,axon density,remyelination,and a reduced relative connective tissue area.Hypoxic pre-conditioned ADSPCs seeded in fibrin conduits are a promising adjunct to current nerve autografts.Further studies are needed to understand the underlying cellular mechanism and to investigate a potential application in clinical practice. | Julius M.Mayer Christian Krug Maximilian M.Saller Annette Feuchtinger Riccardo E.Giunta Elias Volkmer Thomas Holzbach | 2023 | Neural Regeneration Research2023，18，3： | 0 |
| 7 | 汽车用工业用丝的最新生产技术显示文摘化学纤维在今天的汽车工业中是必不可少的。各种民用和工业用丝为司机和乘客提供舒适和安全的产品。本文主要介绍聚酰胺和聚酯工业用丝的生产,以及这些工业用丝的广泛用途和对其化学和物理性能的不同要求。这些要求包括:高韧性、低延伸率、低收缩率和高模量。这些丝具有一个共同的特性:即必须保持长期的高质量。因此要求使用高质量的聚合物和新研制的技术先进的纺丝设备及其工艺控制和自动化系统。 | M.Mayer | 1994 | 产业用纺织品1994，12，4： | 0 |
| 8 | 用于化学纤维纺丝机的Unitens系统显示文摘用于化学纤维纺丝线的巴马格公司的Unitens测量系统是从用于织物生产线的Unitens系统发展而来的,它大量地被世界各地所使用。并适合于化学纤维生产线的特殊条件。而且带有自己的计算机和智能化软件的Unitens是一个高质量线纱张力测量系统,为化学纤维生产厂提供了改善产品质量和提高纺织纤维、工业丝或膨体长丝(BCF)生产效率的方法。 | M.Mayer 李国维 | 1994 | 国外纺织技术(化纤.染整.环境保护分册)1994，，6： | 0 |
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