| 2 | 179例骨髓增生异常综合征的细胞遗传学研究显示文摘一般资料 179例骨髓增生异常综合征(MDS)患者,男女之比为1.21:1,年龄范围1~86岁,平均49.4岁。FAB 分型:RA 42例、RARS 18例、RAEB37例、CMML 22例、RAEB-T 29例,继发于治疗或有职业性诱变剂接触史的 MDS 9例,另有22例因资料不全未分型。研究方法骨髓或外周血经短程(0.5,24,48,72h)培养,常规核型分析。 | D.Haase C.Fonatsch M.Freund B.Wrmann H.Bodenstein H.Bartels B.Stollmann-Gibbels E.Lengfelder 李守新 | 1996 | 德国医学1996，13，2： | 0 |
| 3 | Metabolic signatures of Arabidopsis thaliana abiotic stress responses elucidate patterns in stress priming,acclimation,and recovery显示文摘Temperature,water,and light are three abiotic stress factors that have major influences on plant growth,development,and reproduction.Plants can be primed by a prior mild stress to enhance their resistance to future stress.We used an untargeted metabolomics approach to examine Arabidopsis thaliana 11-day-old seedling’s abiotic stress responses including heat(with and without priming),cold(with and without priming),water-deficit and high-light before and after a 2-day-recovery period.Analysis of the physiological phenotypes showed that seedlings with stress treatment resulted in a reduction in fresh weight,hypocotyl and root length but remained viable.Several stress responsive metabolites were identified,confirmed with reference standards,quantified,and clustered.We identified shared and specific stress signatures for cold,heat,water-deficit,and high-light treatments.Central metabolism including amino acid metabolism,sugar metabolism,glycolysis,TCA cycle,GABA shunt,glutathione metabolism,purine metabolism,and urea cycle were found to undergo changes that are fundamentally different,although some shared commonalities in response to different treatments.Large increases in cysteine abundance and decreases in reduced glutathione were observed following multiple stress treatments highlighting the importance of oxidative stress as a general phenomenon in abiotic stress.Large fold increases in low-turnover amino acids and maltose demonstrate the critical role of protein and starch autolysis in early abiotic stress responses. | Yuan Xu Dana M.Freund Adrian D.Hegeman Jerry D.Cohen | 2022 | Stress Biology2022，2，1： | 0 |
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