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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | SD振子,SD吸引子及其应用显示文摘提供一个新振子命名为SD振子,受扰振子的吸引子称为SD吸引子,它的动力学行为决定于一个光滑参数α的连续变化。这是一个具有强非线性特征的振动系统,它提供了一个从光滑动力学行为向不连续动力学行为光滑转迁的典型示范,这种直接的转迁并不需要连续系统的过渡。当系统为光滑动力学性态时,表现出与Du ffing系统类似的双井等标准动力学行为,而当系统表现为不连续性态时,提供一个新的非连续动力系统模型,它除了表现为标准的双井动力学行为外,也表现出一些新的非标准动力学行为。文中展示了这个系统的转迁过程和特性及其相应的吸引子的复杂动力学行为。 | 曹庆杰 Wiercigroch M Pavlovskaia E E Grebogi C Thompson M T | 2007 | 振动工程学报2007，20，5： | 9 |
| 3 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 4 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 5 | 澳大利亚肉类标准和分级体系显示文摘澳大利亚肉类标准(meat standards Australia,MSA)是一个肉类全面质量管理系统,旨在为消费者提供一个肉类食用品质的准确描述。MSA已经通过对消费者进行大规模的品尝实验,确定了牛肉供应链中影响牛肉可口性的生产、屠宰、加工和价值以及各个生产环节的关键控制点(critical control points,CCPs)评分。这些关键控制点评分通过两种方式管理牛肉的可口性。首先,屠宰加工领域的关键控制点一直作为胴体评分的强制性标准;其次,其他生产和加工领域的关键点控制评分被合并到一个模型当中,用来预测不同个体肌肉和烹饪技巧的可口性。MSA模型可以用来支持新的营销创新。已经有充分的证据表明,消费者愿意为优质牛肉付出高价。目前已出现几个零售的例子采用MSA可口性评分来给牛肉定价。这样胴体价值的计算方法即为每块零售肉质量乘以不同质量评分的价格,并按照零售价的比例支付牛肉生产者。该系统可以用不同的胴体性状相关的经济权重来计算。由于等级是基于持续的质量规模,生产者在这个系统中的质量和产量方面即便小有增加,也会获得相应的经济回报。MSA系统已经支撑了一个新的和创新的营销系统,该系统的定价是透明的,可以帮助生产者对肉品的质量和产量的调整作出明智的决定。MSA系统不仅在澳大利亚有效地用于预测牛肉的可口性,而且在其他国家也都证明了其应用的有效性。在欧洲启动的ProSafeBeef项目也表明,欧洲也可用类似MSA的系统进行肉类的分级。 | R POLKINGHORNE J M THOMPSON J F HOCQUETTE D W PETHICK 霍云龙 孟庆祥 | 2015 | 肉类研究2015，29，2： | 6 |
| 6 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 7 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 8 | Rapid Isolator of high molecular weight plant DNA显示文摘 | Murray M G Thompson W F | 1980 | Nucleic Acids Research1980，8，： | 2 |
| 9 | Is Duplex Surveillance of Value After Leg Vein Bypass Grafting?: Principal Results of the Vein Graft Surveillance Randomised Trial (VGST)显示文摘 | A H. Davies A J. Hawdon M R. Sydes S G. Thompson | 2005 | Circulation2005，，： | 2 |
| 10 | Enhanced band-gap blueshift due to grow Ⅴ intermixing in InGaAsP multiple quantum well laser structures induced by low temperature grown InP显示文摘 | Lee A S W Mackenjie M Thompson D A | 2001 | Appl Phys Lett2001，78，21： | 2 |
| 11 | 澳大利亚MSA体系:通过食用品质评价牛肉品质显示文摘<正>澳大利亚肉类标准(MSA)是一个质量管理体系,旨在为消费者提供牛肉食用品质的准确描述。MSA分级系统中,消费者品尝的感官效果被用来描述牛肉的可口性。简单来讲,未经培训的消费者采用0~100直线标度的方法对牛肉样品的嫩度、多汁性、风味和总体接受度进行测试打分,包括下列语言叙述:不满意等级(无评分级)、普通级(或3星级)、良好级(或4星级)、优级(或5星级)。然后对4个感官指标通过权重换算。 | Pethick D W olkinghorne R P Thompson J M 吴鑫 | 2015 | 中国畜牧杂志2015，51，S1： | 2 |
| 12 | Dietary calcium and dairy products accelerate weight and fat loss during energy restriction in obese adults显示文摘 | ZEMEL M B THOMPSON W ZEMEL P | 2002 | Am J Clin Nutr2002，75，： | 2 |
| 13 | Microstructure and Fracture Morphology in the Welding Zone of Cr18Mo2 Ferritic Stainless Steel显示文摘Microstructure, precipitates and fracture morphology in the weld metal and the heat-affected zone (HAZ) of Cr18Mo2 ferritic stainless steel have been studied by means of metalloscope, SEM,TEM and X-ray diffractometer. Experimental results indicate that crystalline grain coarsening in HAZ is one of the reason resulting in the embrittlement fracture in the welding zone of the ferritic stainless steel. Some precipitates (TiC, TiN and Cr2N) in the steel promote production and development of the brittle cracks. In practical applications. the welding heat input should be as small as possible to prevent embrittlement caused by HAZ grain coarsening. | Li, YJ Zou, ZD Thompson, M | 1996 | Journal of Materials Science & Technology1996，12，6： | 2 |
| 14 | 近期呼吸道感染与心血管疾病风险间关系初探显示文摘 | Clayton TC Thompson M Meade TW 袁志敏(摘译) 刘运德(校) | 2008 | 心血管病学进展2008，29，5： | 2 |
| 15 | Selective detection of aroma compontents by acoustic wave sensors coated with conducting polymers films显示文摘 | Deng Z P Stone D C Thompson M | | Analyst0，121，： | 2 |
| 16 | Potential role of fibroblast growth factor in enhancement of fracture healing显示文摘 | Radomsky M L Thompson A Y Spiro R C | 1998 | Clin Orthop1998，，355： | 2 |
| 17 | Relative efficacy of acute relapse in MS显示文摘 | Thompson AJ ennard C wash M t al | | Neurology0，9，： | 2 |
| 18 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 19 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 20 | An Osteoconductive Collagen/Hyaluronate Matrix for Bone Regenerte显示文摘 | Liu L S Thompson A Y Heidaran M A | 1999 | Biomaterials1999，20，12： | 1 |
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