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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 3 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 4 | Enriched environment and physical activity reverse astrogliodegeneration in the hippoeampus of AD transgenic mice显示文摘 | Rodriguez J J Terzieva S Olabarria M | 2013 | Cell Death Dis2013，4，： | 1 |
| 5 | Aspects of the thermal oxidation, yellowing and stabilization of ethylene vinyl acetate copolymer 显示文摘 | Allen N S Edge M Rodriguez M | 2000 | Polymer Degradation and Stability2000，71，1： | 1 |
| 6 | Application of liquid chromatography in polymer non-ionic antistatic additives analysis 显示文摘 | Gonzdlez Rodriguez M V Dopico-Garcia M S Noguerol Cal R | 2010 | J Sep Sci2010，33，22： | 1 |
| 7 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixeira S Rodriguez M A Pena P De Aza A H De Aza S Ferraz M P Monteiro F J | 2009 | Materials Science & Engineering C-Biomimetic and Supramolecular Systems2009，29，5： | 1 |
| 8 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixelra S Rodriguez M A Pena P ctal | 2009 | Materials Science and Engineering: C2009，29，5： | 1 |
| 9 | Isolation and characterization of pediocin L50, a new bacteriocin from Pediococcus acidilactici with a broad inhibitory spectrum 显示文摘 | CINTAS S Y RODRIGUEZ J M FERNANDEZ M F | 1995 | Appl Enviom Mierobiol1995，61，： | 1 |
| 10 | Effects of Ca( OH)2 treatments( 'overtiming' ) on the composition and toxicity of bagasse hemicellulose hydrolysates显示文摘 | MARTINEZ A RODRIGUEZ M E YORK S W | 2000 | Biotechnology and Bioengineering2000，69，5： | 1 |
| 11 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 12 | Antifungal lipopeptides: a tale of Pseudomycin prodrugs and analogues显示文摘 | Chen S H Rodriguez M | 2003 | Drugs Fut2003，28，5： | 1 |
| 13 | Simultaneous muhi-analyte determination of estrone, isoprpturon, and atrazine in natural waters by the River ANAlyzer ( RIANA), an optical immunosensoroptical immunosenso 显示文摘 | RODRIGUEZ -MOZAZ S REDER S LOPEZ A M J | 2004 | Biosensors & Bioelectronics2004，19，： | 1 |
| 14 | Efficiency of different clay minerals modified with a eationic surfactant in the adsorption of pesticides: influence of clay type and pesticide hydrophobie 显示文摘 | SANCHEZ M M J RODRIGUEZ C M S ANDRADES M S | 2006 | Applied Clay Science2006，31，34： | 1 |
| 15 | Supercritical fluid extraction of fish oil from fish by - products : a compari- son with other methods 显示文摘 | Rodriguez N R Diego S M Behran S | 2012 | Food Engineering2012，，109： | 1 |
| 16 | Effects of Ca(OH)2 treatments (overliming) on the composition and toxicity of bagasse hemicellulose hydrolysates显示文摘 | Martinez A rodriguez M E York S W | 2000 | Biotechnol Bioeng2000，69，5： | 1 |
| 17 | UV-and UV/ Fe(Ⅲ)-enhanced ozonation of nitrobenzene in aqueous solution 显示文摘 | Contreras S Rodriguez M Chamarro E | 2001 | Journal of Photochemistry and Photobiology A: Chemistry2001，142，1： | 1 |
| 18 | Changes in chlorophyll fluorescence during the course of photoperiod and in response to drought in Casuarina eqursetifolia Forst 显示文摘 | Carrasco R M Rodriguez J S Perez P | 2002 | Photosynthetica2002，40，3： | 1 |
| 19 | Lipase from the thermotolerant fungus Rhizopus homothallicus is more thermostable when produced using solid state fermentation than liquid fermentation procedures 显示文摘 | Diaz J C M Rodriguez J A Roussos S | 2006 | Enzyme and Microbial Technology2006，39，5： | 1 |
| 20 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
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