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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | 欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南显示文摘非上皮性卵巢癌是一类少见的卵巢癌,因此,其诊断较难建立。然而,通过仔细观察各种肿瘤的标记物[尤其是人绒毛膜促性腺激素β亚单位(β-hCG)、α-甲胎蛋白(α-AFP)和乳酸脱氢酶(LDH)]、临床体征(如妊娠期体征, | Reed N Millan D Verheijen R Castiglione M On behalf of the ESMO Guidelines Working Group 杨华(译) 郎景和(审校) | 2011 | 国际妇产科学杂志2011，38，4： | 13 |
| 3 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 4 | Migraine prevalence, disease burden, and the need for preventive therapy显示文摘 | R B. Lipton M E. Bigal M Diamond F Freitag M L. Reed W F. Stewart | 2007 | Neurology2007，，5： | 2 |
| 5 | A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis显示文摘 | Pere Puigserver Zhidan Wu Cheol Won Park Reed Graves Margaret Wright Bruce M Spiegelman | 1998 | Cell1998，，6： | 2 |
| 6 | A critical point for random graphs with a given degree sequence显示文摘 | Molloy M Reed B | 1995 | Random Structures and Algorithms1995，6，23： | 1 |
| 7 | Conductance of a molecular junction显示文摘 | Reed M A Zhou C Muller C J | 1997 | Science1997，278，： | 1 |
| 8 | Use of weakly irregular waveguide theory to calculate eigenfrequencies, Q values and RF field functions for gyrotron oscillators 显示文摘 | Reed M E | 1981 | Int J Electronics1981，51，4： | 1 |
| 9 | Predicting residual stresses and distortion when welding aeroengine alloys显示文摘 | Oddy A S Reed R C | 1998 | Canadian Aeronautics and Space Journal1998，44，2： | 1 |
| 10 | Convergence properties of the Nelder-Mead simplex method in low dimensions显示文摘 | Lagarias J C Reeds J A Wright M H | 1998 | SIAM Journal of Optimization1998，9，1： | 1 |
| 11 | Anonymous connections and onion routing 显示文摘 | REED M G SYVERSON P F | 1998 | IEEE Journal on Selected Areas in Communication-Special Issue on Copyright and Privacy Protection1998，16，4： | 1 |
| 12 | Atomic probes: a search for conduction through a single molecule显示文摘 | C J Muller B J Vleeming M A Reed | 1996 | Nanotechnology1996，7，： | 1 |
| 13 | Evaluation of a commercial quailpox virus vaccine(Bio-Pox Qtn) for the control of 'variant' fowlpox virus infections显示文摘 | Fatunmbi O Reed W M | 1996 | Avian Dis1996，40，： | 1 |
| 14 | In vivo Testing of a biostable Polyurethane显示文摘 | Szycher M Reed AM Siciliano AA | 1991 | J Biomater Appl1991，6，1： | 1 |
| 15 | Power relations and community-based tourism planning 显示文摘 | Reed M G | 1997 | Annats of Tourism Research1997，24，3： | 1 |
| 16 | Multicolored hamilton cycles显示文摘 | ALBERT M FRIEZE A REED B | 1995 | Electronic J Combin1995，2，： | 1 |
| 17 | Phenotypic correlations in FTDP-17显示文摘 | Reed LA Wszolek ZK Hutton M | 2001 | Neurobiol Aging2001，22，1： | 1 |
| 18 | Nanofiber technology for burn care显示文摘 | Hromadka M Reed C Han L | 2008 | J Burn Care Res2008，29，5： | 1 |
| 19 | P300 acetyltransferase activity differentially regulates the lo- calization and activity of the FoxO homologues in skeletal muscle 显示文摘 | SENF S M SANDESARA P B REED S A | 2011 | Cell Physiology2011，300，6： | 1 |
| 20 | Water level variations in the Neuse and Pamlico Estuaries, North Carolina due to local and remote forcing 显示文摘 | Reed R E Dickey D A Burkholder J M | 2008 | Estuarine Coastal and Shelf Science2008，76，2： | 1 |
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