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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 3 | Proactive personality, employee creativity, and newcomer outcomes : a longitudinal study显示文摘 | KIM T-Y HON A H CRANT J M | 2009 | Journal of Business and Psychology2009，24，1： | 1 |
| 4 | WebLogo: a sequence logo generator显示文摘 | Crooks G E Hon G ChandoniaJ M | 2004 | Genome Res2004，14，6： | 1 |
| 5 | Evidence for recombination in natural popuiatiotis of porcine circovius type 2 in Hong Kong and mainland China显示文摘 | Ma C M Hon C C Lam T Y | 2007 | Journal of General Virology2007，88，6： | 1 |
| 6 | CT angiograpby of low extremities and aortoiliac system with a multi-detector row helical CT scanner: promise of new oppotunities fulfilled显示文摘 | Hon M | 2001 | Radiology2001，221，1： | 1 |
| 7 | Immunolocalization of antifreeze proteins in winter rye leaves,crown,and root by tissue printing显示文摘 | ANTIKAINEN M GRIFFITH M ZHANG J HON W C YANG D PIHAKASKI-MAUNSBACH K | 1996 | Plant Physiol1996，110，： | 1 |
| 8 | Antifreeze proteins in winter rye are similar to pathogenesis-relatedproteins显示文摘 | W C Hon M Griffith A Mlynarz | 1995 | Plant Physiol1995，109，3： | 1 |
| 9 | ASCE, System System Risk Curves: Probabilistic Performance Scenarios for Highway Networks Subject to Earthquake Damage显示文摘 | Nobuhiko Shiraki Masanobu Shinozuka M Hon | 2007 | Journal of Infrastructure Systems2007，13，1： | 1 |
| 10 | Effect of aging on the growth of intermetallic compounds at the interface of Sn-9Zn-xAg/Cu substrates 显示文摘 | CHANGTC WANG M C HON M H | 2003 | J Crystal Growth2003，250，12： | 1 |
| 11 | Tillage-induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping 显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Soil and Tillage Research1995，34，1： | 1 |
| 12 | The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling显示文摘 | Shi Y Hon M Evans RM | 2002 | Proc Natl Acad Sci U S A2002，99，5： | 1 |
| 13 | Carbon and nitrogen sequestration and soil aggregation under sorghum cropping sequences显示文摘 | Wright A L Hons F M | 2005 | Biology and fertility of soils2005，41，2： | 1 |
| 14 | Tillage impacts on microbial biomass and soil carbon and nitrogen dynamics of corn and cotton rotations显示文摘 | Wright A L Hons F M Matocha J E Jr | 2005 | Appl Soil Ecol2005，29，1： | 1 |
| 15 | Identification of Source Locations in Two-Dimensional Heat Equations显示文摘 | LING L YAMAMOTO M HON Y C | 2006 | Inverse Problems2006，22，： | 1 |
| 16 | Crystal growth of the intermetallic compounds at the Sn-9Zn-xAg/Cu interface during isothermal aging显示文摘 | CHANG T C WANG M C HON M H | 2003 | J Crystal Growth2003，252，13： | 1 |
| 17 | NMR and FT-IR investigation of spinel LiMn2O4 cathode prepared by the tartaric acid gel process显示文摘 | Hon Y M Chung H Y Fung K Z | 2001 | J Solid State Chemistry2001，160，2： | 1 |
| 18 | Soil C extracted with water or K2 SO4 : pH effect on determination of microbial biomass 显示文摘 | HANEY R L FRANZLUEBBERS A J HONS F M | 1999 | Canadian Journal of Soil Science1999，79，4： | 1 |
| 19 | Sesquiterpene lactones from Elephantopus scaber 显示文摘 | BUT P P H HON P M CAO H | 1997 | Phytochemistry1997，44，1： | 1 |
| 20 | Aggressive angiomyxomain females:is radical resection the only option? 显示文摘 | Chan Y M Hon E Ngai S W | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
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