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| 1 | WONCA研究论文摘要汇编——慢性阻塞性肺疾病对亚太地区的影响:基于亚洲人群的EPIC调查显示文摘背景慢性阻塞性肺疾病(COPD)是一种慢性、进行性呼吸减弱的临床病症,主要临床表现为不完全可逆性气流受限。在亚太地区,关于COPD患病率的研究较多,但关于COPD影响的研究较少,本研究旨在对COPD的现患病率及其对亚太地区的影响进行综合阐述。方法 2012年2月1日—5月16日,在亚太地区的9个区域进行人群调查。共有112 300个家庭接受调查,从中抽取符合本研究纳入标准(≥40岁;确诊为COPD、慢性支气管炎或肺气肿,或伴有慢性支气管炎症状)的居民69 279例,其中确诊为COPD的居民为4 289例。采用结构式调查问卷,通过面对面采访或电话随访的形式收集居民的相关资料,最终纳入患者1 841例。结果估算COPD总患病率为6.2%,其中19.1%为重症。调查前的12个月内,近一半患者(46.0%)的病情加重,其中19.0%的患者因病情加重而入院治疗。关于COPD对工作的影响,23.0%的患者表示无法工作,42.0%的患者认为该病限制了工作或活动能力。20.0%服用处方药的患者不知晓自身服用药物的名称;44.0%的患者在调查前12个月内服用过常见口服皮质类固醇处方,而吸入器的使用率(25.0%)较低。仅有37.0%的患者进行了肺功能检查,但89.0%接受检测的患者不知晓检查结果。结论亚太地区的COPD患病率较高,因患病带来的社会经济负担较大。COPD管理能力提升空间较大,患者和医生的疾病相关教育有待加强。 | Lim1 S Chi-Leung Lam D M AR | 2015 | 中国全科医学2015，18，28： | 20 |
| 2 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 3 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 4 | 血液采集和单采期间不良反应的发生率:一项单中心研究显示文摘通常认为异体血液采集的献血者发生不良反应和损伤的发生率低,但自体献血者不良反应发生率的数据则自相矛盾,单采不良反应的发生率和预测献血者反应的因素还知之甚少.
本文分析了作者输血中心1998年1月到2001年6月记录的血液和单采献血者的所有不良反应.作者对发生不良反应与未报告任何不良反应的献血者之间的人口统计学和身体特征进行比较,以便确定不良反应预测因素的存在. | Franchini M Gandini G Gandini AR 洪缨 | 2004 | 国外医学(输血及血液学分册)2004，27，4： | 7 |
| 5 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 6 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 7 | Measurement of bound states in the continuum by a detector embedded in a photonic crystal显示文摘We directly measure optical bound states in the continuum(BICs)by embedding a photodetector into a photonic crystal slab.The BICs observed in our experiment are the result of accidental phase matching between incident,reflected and in-plane waves at seemingly random wave vectors in the photonic band structure.Our measurements were confirmed through a rigorously coupled-wave analysis simulation in conjunction with temporal coupled mode theory.Polarization mixing between photonic crystal slab modes was observed and described using a plane wave expansion simulation.The ability to probe the field intensity inside the photonic crystal and thereby to directly measure BICs represents a milestone in the development of integrated opto-electronic devices based on BICs. | Roman Gansch Stefan Kalchmair Patrice Genevet Tobias Zederbauer Hermann Detz Aaron M Andrews Werner Schrenk Federico Capasso Marko Lončar Gottfried Strasser | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 8 | Glutamate neurotoxicity in cortical cell culture显示文摘 | Choi DW Maulucci-Gedde M Kriegstein AR | 1987 | Neurosci1987，7，2： | 2 |
| 9 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 10 | A shunt active power filter applied to high voltage distribution lines显示文摘 | HAFNER J AREDS M HEUMANN K | 1997 | IEEE Trans on Power Delivery1997，12，1： | 1 |
| 11 | Influence of manual preflaring and torque on the failure rate of ProTaper rotary instruments显示文摘 | Berutti E Negro AR Lendini M | 2004 | J Endod2004，30，： | 1 |
| 12 | Flavonoid genes in pentunia:addition of a limited number of gene copies may lead to a suppression of gene expression显示文摘 | Mur LA Beld M | 1990 | Plant Cell1990，2，： | 1 |
| 13 | Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy显示文摘 | Benson DW Perez-Atayde AR | 2002 | J Clin invest2002，109，3： | 1 |
| 14 | Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders显示文摘 | Takahashi T Yung AR Yücel M | 2008 | Schizophr Res2008，105，13： | 1 |
| 15 | Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age显示文摘 | Gonzalo-Ruiz A Sanz J M Arévalo J | 2005 | J Chem Neuroanat2005，29，1： | 1 |
| 16 | Difereneesin inflammatory eytokine and Toll - like receptor genes and bacterial vaginosis in pregnancy 显示文摘 | Goepfert AR Vamer M Ward K | 2005 | Am J Obstet Gynecol2005，193，： | 1 |
| 17 | Differential regulation of EphA2 in nomlal and malignant cells显示文摘 | Walker-Daniels J Hess AR Hendrix M J | 2003 | Am J Pathol2003，162，4： | 1 |
| 18 | Aripiprazoe, an antipsychotic with a novel mechanismof actianwith psychizophrenia and schizoaffective disorder显示文摘 | Potkin SG Saha AR Kujawa M J | 2003 | Arch Gen Psycheiatry2003，60，： | 1 |
| 19 | Distinct renal injury in early atherosclerosis and renovascular disease 显示文摘 | Chade AR Rodriguez-Porcel M Grande JP | 2002 | Circulation2002，106，9： | 1 |
| 20 | Establishing guidelines for the role of minor salivary gland biopsy in clinical practice for Sj(o)gren' s syndrome显示文摘 | Lee M Rutka JA Slomovic AR | 1998 | J Rheumatol1998，25，2： | 1 |
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