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| 1 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 2 | Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies显示文摘AIM:To investigate the association between statin use and colorectal cancer risk,we conducted an updated meta-analysis of published studies.METHODS:We performed a comprehensive search for studies published up to July 2013.Eligible studies for this meta-analysis were either randomized controlled trials(RCTs)or observational studies(casecontrol or cohort)evaluating any exposure to statins and the risk of colorectal cancer.Two reviewers selected studies based on predefined inclusion criteria,and abstracted the data.Pooled relative risk(RR)estimates with their 95%CI were calculated using fixedand random-effects models.Then,we assessed the potential presence of publication bias and betweenstudies heterogeneity.To evaluate the results,we also performed a'leave-one-out'sensitivity analysis.RESULTS:A total of 40 studies,involving more than eight million subjects,contributed to the analysis.They were grouped on the basis of study design and,consequently,three separate meta-analyses were conducted.A similar modest reduction in the risk of colorectal cancer with statin use was observed,which was not statistically significant among RCTs(RR=0.89,95%CI:0.74-1.07;n=8),but reached statistical significance among cohort studies(RR=0.91,95%CI:0.83-1.00;n=13)and case-control studies(RR=0.92,95%CI:0.87-0.98;n=19).While we did not find significant evidence of selective outcome reporting or publication bias,substantial heterogeneity was detected,mainly among the observational studies.The sensitivity analysis confirmed the stability of our results.CONCLUSION:A modest reduction in risk of colorectal cancer among statin users cannot be disproved.Further targeted research is warranted.2014 Baishideng Publishing Group Co.,Limited.All | Theodore Lytras Georgios Nikolopoulos Stefanos Bonovas | 2014 | World Journal of Gastroenterology2014，20，7： | 7 |
| 3 | Calcium supplementation for the prevention of colorectal adenomas: a systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To determine the efficacy of calcium supplementation in reducing the recurrence of colorectal adenomas.METHODS: We conducted a systematic review and meta-analysis of published studies. We searched Pub Med, Scopus, the Cochrane Library, the WHO International Clinical Trials Registry Platform, and the Clinical Trials.gov website, through December 2015. Randomized, placebo-controlled trials assessing supplemental calcium intake for the prevention of recurrence of adenomas were eligible for inclusion. Two reviewers independently selected studies based on predefined criteria, extracted data and outcomes(recurrence of colorectal adenomas, and advanced or 'high-risk' adenomas), and rated each trial's riskof-bias. Between-study heterogeneity was assessed, and pooled risk ratio(RR) estimates with their 95% confidence intervals(95%CI) were calculated using fixed- and random-effects models. To express the treatment effect in clinical terms, we calculated the number needed to treat(NNT) to prevent one adenoma recurrence. We also assessed the quality of evidence using GRADE.RESULTS: Four randomized, placebo-controlled trials met the eligibility criteria and were included. Daily doses of elemental calcium ranged from 1200 to 2000 mg, while the duration of treatment and follow-up of participants ranged from 36 to 60 mo. Synthesis of intention-to-treat data, for participants who had undergone follow-up colonoscopies, indicated a modest protective effect of calcium in prevention of adenomas(fixed-effects, RR = 0.89, 95%CI: 0.82-0.96; randomeffects, RR = 0.87, 95%CI: 0.77-0.98; high quality of evidence). The NNT was 20(95%CI: 12-61) to prevent one colorectal adenoma recurrence within a period of 3 to 5 years. On the other hand, the association between calcium treatment and advanced adenomas did not reach statistical significance(fixed-effects, RR = 0.92, 95%CI: 0.75-1.13; random-effects, RR = 0.92, 95%CI: 0.71-1.18; moderate quality of evidence). CONCLUSION: Our results suggest a modest chemopreventive effect of calcium supplements against recurrent colorectal adenomas over a period of 36 to 60 mo. Further research is warranted. | Stefanos Bonovas Gionata Fiorino Theodore Lytras Alberto Malesci Silvio Danese | 2016 | World Journal of Gastroenterology2016，22，18： | 6 |
| 4 | Benefits and limitation of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgcrinos C Lytras D | 2003 | Langenbecks Arch Sury2003，387，1112： | 1 |
| 5 | Language, Discourse and Identities:snapshots from Greek contexts 显示文摘 | GEORGAKOPOULOU A LYTRA V | 2009 | Prag- matics2009，19，： | 1 |
| 6 | Benefits and limitation of enteral nutrition in the early postoperative period显示文摘 | Avgefinos C Lytras D | 2003 | Langenbecks Arch Sury2003，387，： | 1 |
| 7 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，： | 1 |
| 8 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，： | 1 |
| 9 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenia C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，1112： | 1 |
| 10 | Study of Culex tritaeniorhynchus and species composition of mosquitoes in a rice field in Greece显示文摘 | Lytra I Emmanouel N | 2014 | Acta Trop2014，2，： | 1 |
| 11 | Benefit and limitations of enteral nurition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，： | 1 |
| 12 | A Knowledge Management Roadmap for E-Learning: The Way Ahead显示文摘 | Miltiadis D Lytras Ambj?m Naeve Athanasia Pouloudi | 2005 | International Journal of Distance Education Technologies2005，，： | 1 |
| 13 | Effect of muscle type, salt and pH on cooked meat haemoprotein formation inlamb and beef显示文摘 | Lytras G N Geileskey A King R D | 1999 | MeatScience1999，2，： | 1 |
| 14 | Effect of muscle type, salt and pH on cooked meat haemoprotein formation in lamb and beef显示文摘 | G.N Lytras A Geileskey R.D King D.A Ledward | 1999 | Meat Science1999，，2： | 1 |
| 15 | Persistent early organ failure:defining the high-risk group of patients with severe acute pancreatitis显示文摘 | Lytras D Manes K Triantopoulou C | 2008 | Pancreas2008，36，3： | 1 |
| 16 | Benefits and limitations of enteral nutrition in the early postoperative period 显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，1112： | 1 |
| 17 | Persistent early organ failure defining the high-risk group of patients with severe acute pancreatitis显示文摘 | Lytras D Manes K Triantopoulou C | 2008 | Pancreas2008，36，： | 1 |
| 18 | Ontologies and the semantic web for E-learning 显示文摘 | SAMPSON D G LYTRAS M D WAGNER G | 2004 | Journal of Educational Technology and Society2004，7，4： | 1 |
| 19 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbecks Arch Surg2003，387，11： | 1 |
| 20 | Benefits and limitations of enteral nutrition in the early postoperative period显示文摘 | Dervenis C Avgerinos C Lytras D | 2003 | Langenbeck''s Arch Surg2003，387，1112： | 1 |
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