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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 3 | Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma显示文摘 | Manders P Beex LV Tjan-Heijnen VC | 2003 | Cancer2003，98，10： | 1 |
| 4 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 5 | Evaluation of factorsimpacting clinical outcome and cost effectiveness of the S-ICD : de-sign and rationale of the effortless S-ICD Registry 显示文摘 | Pedersen SS Lambiase P Boersma LV | 2012 | PACE2012，35，5： | 1 |
| 6 | Roles of SM22ct in cellular plasticity and vascular diseases 显示文摘 | Dong L H Lv P Han M | 2012 | Cardiovas Hematol Disord Drug Targets2012，12，2： | 1 |
| 7 | The effect of chain extension method on the properties of polyurethane/SiO2 composites显示文摘 | LV Z P LI X N YU X | 2012 | Materials and Design2012，35，： | 1 |
| 8 | Review of an Influenza Surveil- lance System, Beijing, People's Republic of China显示文摘 | Yang P Duan W Lv M | 2009 | Emerg Infect Dis2009，15，10： | 1 |
| 9 | The identification and characteristics of salinity-related microRNAs in gills of Portunus trituberculatus 显示文摘 | Lv J Liu P Gao B | 2016 | Cell Stress and Chaperones2016，21，1： | 1 |
| 10 | Object - based spatial feature for classification of very high resolution remote sensing images 显示文摘 | Zhang P Lv Z Shi W | 2013 | IEEE Geoscience & Remote Sensing Letters2013，10，6： | 1 |
| 11 | IL-12 dependent/IFN gamma independent expression of CCR5 by myelin reactive T cells correlates with encephalitogenicity显示文摘 | Bagaeva LV Williams L P Segal BM | 2003 | J Neuroimmunol2003，137，： | 1 |
| 12 | Synthesis and electrochemical properties of LiMn204 spinel phase with nanostructure显示文摘 | Ye S H Lv J Y Gao X P | 2004 | Electrochimica Acta2004，49，： | 1 |
| 13 | 查看详情显示文摘 | Xu H Shi X Ma H Lv Y H Zhang L P Mao Z P | | 0，，： | 1 |
| 14 | An experi- mental study on biomass air-steam gasification in a flu- idized bed 显示文摘 | LV P M XIONG Z H CHANG J | 2004 | Bioresource and Technology2004，95，1： | 1 |
| 15 | Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis显示文摘 | Bellelis P Barbeiro DF Rizzo LV | 2013 | Fertil Steril2013，99，7： | 1 |
| 16 | V-ATPase is involved in silk- worm defense response against Bombyx raori Nucleopolyhe- drovirus显示文摘 | LV P XIA H GAO L et ol | 2013 | PLoS One2013，8，64： | 1 |
| 17 | Material decomposition images gener-ated from spectral CT : detectability of urinary calculi and influ-encing factors 显示文摘 | Lv P Zhang Y Liu J | 2014 | Acad Radiol2014，21，1： | 1 |
| 18 | An integrated hy- pothesis that considers drusen as biomarkers of immune- mediated processes at the RPE-Bruch' s membrane inter- face in aging and age-related macular degeneration显示文摘 | HAGEMAN GS LUTHERT P J VICTOR CHONG NH JOHN- SON LV ANDERSON DH MULLINS RF | 2001 | Prog Retin Eye Res2001，20，6： | 1 |
| 19 | In situ normothermic regional perfusion for controlled donation after circulatory death:the United Kingdom experience显示文摘 | Oniscu GC Randle LV Muiesan P | 2014 | Am J Transplant2014，14，12： | 1 |
| 20 | Departure of Condensa- tion Droplets on Superhydrophobie Surfaces 显示文摘 | Lv C Hao P Yao Z | 2015 | Lang- muir2015，31，8： | 1 |
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