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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 3 | Selective dissolution of hydrated blast furnaces slag cements 显示文摘 | Luke K Glasser F P | 1987 | Cement and Concrete Research1987，17，2： | 2 |
| 4 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 5 | Recent developments in semiconductor gamma-ray detectors 显示文摘 | Luke P N Amman M TindaU C | 2005 | Journal of Radloanalyrical and Nuclear Chemistry2005，264，1： | 1 |
| 6 | Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor显示文摘 | Sven P Luke M | 2000 | Clin Cancer Res2000，，6： | 1 |
| 7 | Design of deep pile cap by strut-and-tie model显示文摘 | Adebar P ZHOU Luke | 1996 | ACI Structural Journal1996，93，4： | 1 |
| 8 | Industrial applications of electrical tomography to solid conveying显示文摘 | LUKE S P WILLIAMS R A | 1997 | Measurement & Control1997，，30： | 1 |
| 9 | Measurement of gaseous and aqueous trace formaldehyde:Revisiting the pentanedione reaction and field applications显示文摘 | Li J Dasgupta P K Luke W | 2005 | Anal Chim Acta2005，531，： | 1 |
| 10 | Biasing coevolutionary search for optimal multiagent behaviors显示文摘 | PANAIT L LUKE S WIEGAND R P | 2007 | IEEE Transactions on Evolutionary Computation2007，10，6： | 1 |
| 11 | Economic analysis in the MRO in- dustry: an options approach 显示文摘 | LUKE T M CHAN S P | 2004 | The Engineering Econo- mist2004，49，5： | 1 |
| 12 | A tech- nique for the automatic detection of insect clutter in cloud radar returns 显示文摘 | LUKE E P KOLLIAS P JOHNSON K L | 2008 | Journal of Atmospheric and Oceanic Technology2008，25，9： | 1 |
| 13 | 'One-pot' meth- ylation of Fmoc amino acids 显示文摘 | R W A Luke P G T Boyce E K Dorling | 1996 | Tetrahedron Lett1996，37，2： | 1 |
| 14 | The Associ- ation of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis显示文摘 | Houssami N Macaskill P Luke Marinovich M | 2014 | Ann Surg Oncol2014，21，3： | 1 |
| 15 | Mir451 regulates zebrafish erythroid maturation in vivo via its target gata2显示文摘 | LUKE P JUDITH E L WIGARD P K | 2009 | Blood2009，113，： | 1 |
| 16 | Bronchopleural fistula after pneumonectomy显示文摘 | Javadpour H Sidhu P Luke DA | 2003 | Ir J Med Sci2003，172，1： | 1 |
| 17 | Solubility and aging of calcium silicate hydrate in alkaline solution at 25 ℃ 显示文摘 | Luke K Glasser F P | 1989 | J Am Ceram Soc1989，72，4： | 1 |
| 18 | Single - polarity charge sensing in ionization detectors using coplanar electrodes 显示文摘 | Luke P N | 1994 | Appl Phys Lett1994，65，： | 1 |
| 19 | ' Literacies' programs:debates and demands in cultural context 显示文摘 | FREEBODY P LUKE A | 1990 | Prospect1990，5，3： | 1 |
| 20 | Electrode Configuration and Energy Resolution in Gamma- ray Detectors 显示文摘 | | 1996 | Nucl Instr Meth Phys Res A1996，380，： | 1 |
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