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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | Visualization of ischaemic penumbra using a computed tomography pefusion method 显示文摘 | Cheung R T Cheng P W Lui W M | 2003 | Cerebrovasc Dis2003，15，： | 1 |
| 4 | TGF-beta regates the blood testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway : an in vivo study显示文摘 | Lui W Y Wong C H Mruk D D | 2003 | Endocrinology2003，14，41： | 1 |
| 5 | Analysis and behaviour of flexibly-jointed frames显示文摘 | Lui E M Chen W F | 1986 | Engineering Structure1986，8，4： | 1 |
| 6 | Analysis and behavior of flexi- bly-jointed frames 显示文摘 | Lui E M Chen W F | 1986 | Engineering Structures1986，8，2： | 1 |
| 7 | Evaluation of a rapid screening test for mi- croalbuminuria with a spot meusarement of uriaealbumin - creatinine ratio 显示文摘 | Ng W Lui KF Thai A | 2000 | Diabet Med2000，17，1： | 1 |
| 8 | Associations of serum osteoprotegerin levels with diabetes,stroke,bone density,fractures,and mortality in elderly women 显示文摘 | LUI L Y CUMMINGS S R | 2001 | J Clin Endocrinol Metab2001，86，2： | 1 |
| 9 | Dual methods for nonconvex spectrum optimization of multicarrier systems 显示文摘 | Yu W Lui R | 2006 | IEEE Transactions on Communication2006，54，6： | 1 |
| 10 | Patterns of Known and Novel Small RNAs in Human Cervical Cancer 显示文摘 | LUI W O POURMAND N PATYERSON B K | 2007 | Cancer Research2007，67，13： | 1 |
| 11 | Effect of hydrothermal treatment on microstructural feature and bonding strength of plasma-sprayed hydroxyapatite on Ti-6Al-4V显示文摘 | YANG C W LUI T S LEE T M | 2004 | Materials Transactions2004，45，9： | 1 |
| 12 | Thermal Effects Liquid Oxygen Hydrostatic Journal Bearings 显示文摘 | Zhou Yang Luis San Andres Dara W Childs | 1996 | Tribology transactions1996，39，： | 1 |
| 13 | Multi -scale two -phase Ti -A1 with high strength and plasticity through consolidation of particles by severe plastic deformation 显示文摘 | Lui E W Xu W Wu X | 2011 | Scripta Materialia2011，65，8： | 1 |
| 14 | Range-based source localication with pure reflector in presence of multipath propagation显示文摘 | Lui K W K So H C | 2010 | Electronics Letters2010，46，8： | 1 |
| 15 | Effects of joint flexibility on the behavior of steel frames显示文摘 | Chen W F Lui E M | 1987 | Computers & Structures1987，26，5： | 1 |
| 16 | Arginine modulated cyclosporine-induced immune suppression in rats transplanted with gastric cancer cells显示文摘 | Kung S P Wu C W Lui W Y | 2001 | In Vivo2001，15，1： | 1 |
| 17 | A Novel Broadband Multi-slot Antenna Fed by Microstrip Line显示文摘 | CHENG C H CHENG Y | 2005 | Microwave and Optical Technology Letters2005，45，1： | 1 |
| 18 | Composition Optimization of Etruded Starch Foams Using Response Surface Methodology 显示文摘 | LUI W B PENG J Y | 2004 | Packaging Technology and Science2004，17，6： | 1 |
| 19 | Terbutaline inhalation suppresses fentanyl-induced coughing 显示文摘 | Lui P W Hsing C H Chu Y C | 1996 | Can J An- aesth1996，43，12： | 1 |
| 20 | EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer显示文摘 | Mao W Luis E Ross S | 2004 | Cancer Res2004，64，3： | 1 |
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