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| 1 | Evaluation of ketamine abuse using hair analysis: concentration trends in a Singapore population 显示文摘 | Leong HS Tan NL Lui CP | 2005 | J Anal Toxicol2005，29，5： | 1 |
| 2 | Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells显示文摘 | Lui VW Lau CP Ho K | 2011 | Invest New Drugs2011，29，6： | 1 |
| 3 | Integration of the rmalstress and lifetime supervision system of steam turbine rotors显示文摘 | Antonio CP Luis SR Jesus NG | 2008 | Proceedings of the ASME Turbo Expo2008，，2： | 1 |
| 4 | An RNA-directed nucleo- side anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl) cytosine (ECyd), elicits antitumor effect via TP53-induced Gly- colysis and Apoptosis Regulator (TIGAR) downregulation 显示文摘 | Lui VW Lau CP Cheung CS | 2010 | Biochem Pharmacol2010，79，12： | 1 |
| 5 | Nosocomial bloodstream infections in Brazilian hospitals:analysis of 2,563 cases from a prospective nationwide surveillance study显示文摘 | Alexandre RM Luis FC Antonio CP | 2011 | J clin microbiol2011，5，： | 1 |
| 6 | Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carci- noma ceils 显示文摘 | Lui VW Lau CP Ho K | 2011 | Invest New Drugs2011，29，6： | 1 |
| 7 | Prostatic arterial embolization to treat benign prostatic hyperplasia 显示文摘 | Joao MP Luis CP Tiago B | 2011 | Journal of Vascular and Interventional Radiology2011，22，1： | 1 |
| 8 | Sustained antitumor activity by co-targeting mTOR and the microtubule with temsirolimus/vinblastine combination in hepatocellular carcinoma显示文摘 | Zhou Q Lui VW Lau CP | 2012 | Biochem Pharmacol2012，83，： | 1 |
| 9 | Somenumerical results on the inuence of measurement strategies and load patterns in the EIT inverse problem 显示文摘 | Franciane CP Luis PSB | 2010 | Journal of Physics: Conference Series2010，224，1： | 1 |
| 10 | Some numerical results on the inuence of measurement strategies and load patterns in the EIT inverse problem显示文摘 | Franciane CP Luis PSB | 2010 | J Phys:Conf Ser2010，224，1： | 1 |
| 11 | Anti - invasion, anti - proliferation and anoikis - sensitization activities of Lapatinib in nasopharynge- al carcinoma cells 显示文摘 | Lui VW Lau CP Ho K | 2011 | Invest New Drugs2011，29，6： | 1 |
| 12 | Small joint arthroscopy in foot and ankle 显示文摘 | Lui TH Yuen CP | 2015 | Foot Ankle Clin2015，20，1： | 1 |
| 13 | Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy显示文摘Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-synucleinopathy.As Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection.This study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced neuropathology.Accordingly,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the striatum.In addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia nigra.These effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor behavior.Our results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor deficits.Increased neurotrophic astrocytes and brain-derived neurotrophic factor can mediate the rNurr1-V5 effect,supporting its potential clinical use in the treatment of Parkinson’s disease. | Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong | 2024 | Neural Regeneration Research2024，19，9： | 0 |
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