|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale显示文摘One of the most important points in the meta-analyses is certainly represented by the assessment of the quality of the studies included in such research. The meta-analyses are considered the highest level of evidence in science. Also for this reason, the quality of the studies included should be accurately evaluated by standardized tools. The overall results of the metaanalysis depend indeed also on a rigorous evaluation of the studies quality. Among all the possible tools for this complex evaluation, the Newcastle Ottawa Scale(NOS) is one of the most used worldwide, above all for observational studies. In this review, we will discuss the strengths and limitation of the NOS, also on the basis of the branch of science in which it has been applied. | Claudio Luchini Brendon Stubbs Marco Solmi Nicola Veronese | 2017 | World Journal of Meta-Analysis2017，5，4： | 35 |
| 2 | Peripartal rumen-protected methionine supplementation to higher energy diets elicits positive effects on blood neutrophil gene networks, performance and liver lipid content in dairy cows显示文摘Background: Main objectives were to determine to what extent Smartamine M(SM) supplementation to a prepartal higher-energy diet could alter neutrophil(PMN) and liver tissue immunometabolic biomarkers, and whether those responses were comparable to those in cows fed a prepartal lower-energy diet(CON).Results: Twenty-eight multiparous Holstein cows were fed CON(NEL= 1.24 Mcal/kg DM) during d-50 to d-22 relative to calving. From d-21 to calving, cows were randomly assigned to a higher-energy diet(OVE, n = 9; NEL= 1.54 Mcal/kg DM), OVE plus SM(OVE + SM, n = 10; SM = 0.07 % of DM) or remained on CON(n = 9). Al cows received the same basal lactation diet(NEL= 1.75 Mcal/kg DM). Supplementation of SM(OVE + SM) continued until 30 d postpartum. Liver biopsies were harvested at d-10, 7, and 21 relative to parturition. Blood PMN isolated at-10, 3, and 21 d relative to calving was used to evaluate gene expression. As expected, OVE increased liver lipid content postpartum; however,cows fed OVE + SM or CON had lower concentrations than OVE. Compared with OVE, cows in CON and OVE + SM had greater DMI postpartum and milk production. Furthermore, cows fed OVE + SM had the greatest milk protein and fat percentage and lowest milk SCC despite having intermediate PMN phagocytic capacity. Adaptations in PMN gene expression in OVE + SM cows associated with the lower SCC were gradual increases from-10 to 21 d in genes that facilitate migration into inflammatory sites(SELL, ITGAM), enzymes essential for reducing reactive oxygen metabolites(SOD1, SOD2), and a transcription factor(s) required for controlling PMN development(RXRA). The greater expression of TLR4 on d 3, key for activation of innate immunity due to inflammation, in OVE compared with CON cows suggests a more pronounced inflammatory state. Feeding OVE + SM dampened the upregulation of TLR4, despite the fact that these cows had similar expression of the pro-inflammatory genes NFKB1 and TNF as OVE. Cows in CON had lower overall expression of these inflammation-related genes and GSR, which generates reduced glutathione, an important cellular antioxidant.Conclusions: Although CON cows appeared to have a less stressful transition into lactation, SM supplementation was effective in alleviating negative effects of energy-overfeeding. As such, SM was beneficial in terms of production and appeared to boost the response of PMN in a way that improved overall cow health. | Cong Li Fernanda Batistel Johan Samir Osorio James K.Drackley Daniel Luchini Juan J.Loor | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 8 |
| 3 | Electroconvulsive therapy in catatonic patients: Efficacy and predictors of response显示文摘Recent evidence favors the view of catatonia as an autonomous syndrome, frequently associated with mood disorders, but also observed in neurological, neurodevelop-mental, physical and toxic conditions. From our systematic literature review, electroconvulsive therapy(ECT) results effective in all forms of catatonia, even after pharmacotherapy with benzodiazepines has failed. Response rate ranges from 80% to 100% and results superior to those of any other therapy in psychiatry. ECT should be considered first-line treatment in patients with malignant catatonia, neuroleptic malignant syndrome, delirious mania or severe catatonic excitement, and in general in all catatonic patients that are refractory or partially responsive to benzodiazepines. Early intervention with ECT is encouraged to avoid undue deterioration of the patient's medical condition. Little is known about the long-term treatment outcomes following administration of ECT for catatonia. The presence of a concomitant chronic neurologic disease or extrapyramidal deficit seems to be related to ECT non-response. On the contrary, the presence of acute, severe and psychotic mood disorder is associated with good response. Severe psychotic features in responders may be related with a prominent GABAergic mediated deficit in orbitofrontal cortex, whereas non-responders may be characterized by a prevalent dopaminergic mediated extrapyramidal deficit. These observations are consistent with the hypothesis that ECT is more effective in 'top-down' variant of catatonia, in which the psychomotor syndrome may be sustained by a dysregulation of the orbitofrontal cortex, than in 'bottom-up' variant, in which an extrapyramidal dysregulation may be prevalent. Future research should focus on ECT response in different subtype of catatonia and on efficacy of maintenance ECT in long-term prevention of recurrent catatonia. Further research on mechanism of action of ECT in catatonia may also contribute to the development of other brain stimulation techniques. | Federica Luchini Pierpaolo Medda Michela Giorgi Mariani Mauro Mauri Cristina Toni Giulio Perugi | 2015 | World Journal of Psychiatry2015，5，2： | 5 |
| 4 | Ampulla of Vater carcinoma: Molecular landscape and clinical implications显示文摘Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well. | Antonio Pea Giulio Riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa Claudio Luchini | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 4 |
| 5 | Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows显示文摘Background: Feeding higher-energy prepartum is a common practice in the dairy industry. However, recent data underscore how it could reduce performance, deepen negative energy balance, and augment inflammation and oxidative stress in fresh cows. We tested the effectiveness of rumen-protected methionine in preventing the negative effect of feeding a higher-energy prepartum. Multiparous Holstein cows were fed a control lower-energy diet(CON, 1.24 Mcal/kg DM; high-straw) during the whole dry period(~50 d), or were switched to a higher-energy(OVE, 1.54 Mcal/kg DM), or OVE plus Smartamine M(OVE + SM; Adisseo NA) during the last 21 d before calving.Afterwards cows received the same lactation diet(1.75 Mcal/kg DM). Smartamine M was top-dressed on the OVE diet(0.07% of DM) from -21 through 30 d in milk(DIM). Liver samples were obtained via percutaneous biopsy at -10, 7 and 21 DIM. Expression of genes associated with energy and lipid metabolism, hepatokines, methionine cycle, antioxidant capacity and inflammation was measured.Results: Postpartal dry matter intake, milk yield, and energy-corrected milk were higher in CON and OVE + SM compared with OVE. Furthermore, milk protein and fat percentages were greater in OVE + SM compared with CON and OVE. Expression of the gluconeogenic gene PCK1 and the lipid-metabolism transcription regulator PPARA was again greater with CON and OVE + SM compared with OVE. Expression of the lipoprotein synthesis enzyme MTTP was lower in OVE + SM than CON or OVE. Similarly, the hepatokine FGF21, which correlates with severity of negative energy balance, was increased postpartum only in OVE compared to the other two groups. These results indicate greater liver metabolism and functions to support a greater production in OVE + SM. At 7 DIM, the enzyme GSR involved in the synthesis of glutathione tended to be upregulated in OVE than CON-fed cows, suggesting a greater antioxidant demand in overfed cows. Feeding OVE + SM resulted in lower similar expression of GSR compared with CON. Expression of the methionine cycle enzymes SAHH and MTR, both of which help synthesize methionine endogenously, was greater prepartum in OVE + SM compared with both CON and OVE, and at 7 DIM for CON and OVE + SM compared with OVE, suggesting greater Met availability. It is noteworthy that DNMT3A, which utilizes S-adenosylmethionine generated in the methionine cycle, was greater in OVE and OVE + SM indicating higher-energy diets might enhance DNA methylation, thus, Met utilization.Conclusions: Data indicate that supplemental Smartamine M was able to compensate for the negative effect of prepartal energy-overfeeding by alleviating the demand for intracellular antioxidants, thus, contributing to the increase in production. Moreover Smartamine M improved hepatic lipid and glucose metabolism, leading to greater liver function and better overall health. | Mario Vailati-Riboni Johan S.Osorio Erminio Trevisi Daniel Luchini Juan J.Loor | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 3 |
| 6 | 不同来源瘤胃保护蛋氨酸对泌乳奶牛产奶量和氮利用率的影响显示文摘试验旨在确定以异丙基-2-羟基-4-(甲硫基)-丁酸(HMBi)或瘤胃保护蛋氨酸(RPM,反刍蛋氨酸,美国乔治亚州阿尔法瑞塔市安迪苏公司生产)形式提供可吸收蛋氨酸与2-羟基-4-(甲硫基)-丁酸(HMBi)一起饲喂或不一起饲喂泌乳奶牛的产奶量反应,并确定添加蛋氨酸是否允许给奶牛饲喂粗蛋白低日粮。70头奶牛根据胎次和泌乳天数分成14个组,随机分配为以苜蓿、玉米青贮和高水分玉米为基础日粮的处理:①日粮含粗蛋白15.6%、不添加蛋氨酸(负对照组);②日粮含粗蛋白15.6%+HMBi0.17%;③日粮含粗蛋白15.6%+RPM0.06%+HMB0.10%;④日粮含粗蛋白15.6%+RPM0.06%;⑤日粮含粗蛋白16.8%、不添加蛋氨酸(正对照组)。假定摄取的HMBi50%从胃肠道被吸收,RPM中80%蛋氨酸被小肠吸收。试验结果表明,添加HMBi和RPM增加可代谢蛋氨酸供给9g·d-1,赖氨酸与蛋氨酸比率从3.6降低到3.0。在2周的协变量期(期间所有奶牛饲喂相同的日粮)之后,给奶牛饲喂试验日粮12周。试验结果表明,日粮不会影响奶牛的干物质采食量(平均数±标准差,25.0±0.3kg·d-1)、体增重(0.59±0.2kg·d-1)、产奶量(41.7±0.6kg·d-1),然而,饲喂HMBi可提高奶牛能量校正奶产量、乳蛋白产量和无脂固形物产量。而且,添加蛋氨酸的3种日粮,观察到奶牛乳脂含量、脂肪和真蛋白产量有提高的趋势。RPM处理组的表观氮效率(牛奶氮/吸收氮)最高。饲喂粗蛋白16.8%、不添加蛋氨酸的奶牛乳中尿素氮与尿素氮和总氮的尿排泄提高,表观氮效率从34.5%下降到30.2%,而没有改善产奶量。试验结果表明,饲喂HMBi或RPM奶牛的产奶量和氮利用率获得相似的改善。 | Broderick G A Luchini N D Sloan B K Devillard E 张树金 | 2011 | 饲料博览2011，，10： | 2 |
| 7 | Effect of feeding different sources of rumen-protected methionine on milk pro- duction and N-utilization in lactating dairy cows显示文摘 | Chen Z H Broderick G A Luchini N D | 2011 | Journal of Dairy Science2011，94，4： | 1 |
| 8 | Tread depth effects on tire rolling resistance 显示文摘 | Luchini J R Motil M M Mars W V | 2001 | Tire Science and Technology2001，29，3： | 1 |
| 9 | Contact profilometry and correspondence analysis to correlate surface properties and cel adhesion in vitro of uncoated and coated Ti and Ti6Al4V disks显示文摘 | Bagno A Genovese M Luchini A | | 0，，12： | 1 |
| 10 | Tire rolling loss computation with the finite element method显示文摘 | Luchini J R Peters J M Arthur R H | 1994 | Tire Science and Technology1994，22，4： | 1 |
| 11 | Degradation of the insecticide parathion in methanol by gamma-irradiation显示文摘 | Luchini L C Peres T B Rezende M O | 1999 | Radioanalytical and Nuclear Chemistry1999，241，1： | 1 |
| 12 | Effect of feeding different sources of rumen-protected methionine on milk production and N-utilization in lactating dairy cows 显示文摘 | CHEN Z H BRODERICK G A LUCHINI N D | 2011 | Journal of Dairy Science2011，94，4： | 1 |
| 13 | Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives显示文摘 | Aline Witaicenis Leonardo Noboru Seito Alexandre da Silveira Chagas Luiz Domingues de Almeida Ana Carolina Luchini Patrícia Rodrigues-Orsi Silvia Helena Cestari Luiz Claudio Di Stasi | 2013 | Phytomedicine2013，，： | 1 |
| 14 | Contact prolometry and correspondence analysis to correlate surface properties and cell adhesion in vitro of uncoated and coated Ti and Ti6Al4V disks显示文摘 | Bagno A Genovese M Luchini A | 2004 | Biomaterials2004，25，： | 1 |
| 15 | Chronic musculoskeletal pain and depressive symptoms in the general population:an analysis of the 1st National Health and Nutrition Examination Survey data显示文摘 | Magni G Caldieron C Luchini S | 1990 | Pain1990，43，4： | 1 |
| 16 | Video display terminal use during pregnancy and reproductive outcome-a -meta-analysis显示文摘 | Parazzini F Luchini L La Vecchia C | 1993 | J Epidemiol Community Health1993，47，4： | 1 |
| 17 | Production and Metabolic Responses of Periparturient Holstein Cows to Dietary Conjugated Linoleic Acid and trans-Octadecenoic Acids显示文摘 | Selberg K T Lowe A C Staples C R Luchini N D Badinga L | 2004 | Journal of Dairy Science2004，87，： | 1 |
| 18 | Effect of storage system and dry matter content on the composition of alfalfa silage显示文摘 | Luchini N D Broderick G A Muck R E | 1997 | J Dairy Sci1997，80，： | 1 |
| 19 | Tire rolling computation with the finite element method 显示文摘 | Luchini J R Peters J M Arthur R H | 1994 | Tire Science and Technology1994，22，4： | 1 |
| 20 | Methionine Requirements for the Preimplantation Bovine Embryo显示文摘 | Bonilla L Luchini D Devillard E | 2010 | Journal of Reproduction and Development2010，56，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员