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| 1 | Calcium phosphate-based materials regulate osteoclast-mediated osseointegration显示文摘Calcium phosphate-based materials(CaP)have been widely used as bone graft substitutes with a decent osseointegration.However,the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive.The aim of this study is to find the mechanism how osteoclast behaviors mediate bone healing with CaP scaffolds.Recent reports show that behaviors of osteoclast are closely related with osteogenesis,thus we make a hypothesis that active osteoclast behaviors induced by CaP facilitate bone healing.Here,we found a new mechanism that CaP can regulate osteoclast-mediated osseointegration.Calcium phosphate cement(CPC)is selected as a representative CaP.We demonstrate that the osteoclast-mediated osseointegration can be strongly modulated by the stimulation with CaP.An appropriate Ca/P ratio in CaP can effectively promote the RANKL-RANK binding and evoke more activated NF-κB signaling transduction,which results in vigorous osteoclast differentiation.We observe significant improvement of bone healing in vivo,owing to the active coupling effect of osteoclasts.What is more noteworthy is that the phosphate ions released from CaP can be a pivotal role regulating osteoclast activity by changing Ca/P ratio readily in materials.These studies suggest the potential of harnessing osteoclast-mediated osteogenesis in order to develop a materials-manipulated approach for improving osseointegration. | Xiaogang Wang Yuanman Yu Luli Ji Zhen Geng Jing Wang Changsheng Liu | 2021 | Bioactive Materials2021，6，12： | 4 |
| 2 | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis显示文摘Implant loosening remains a major clinical challenge for osteoporotic patients.This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis,which results in poor bone repair.Strontium(Sr)has been widely accepted as an anti-osteoporosis element.In this study,we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions.The results showed that Ca and Sr exhibited different mineralization behaviors.The main mineralization products for Ca were CaHPO4⋅2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased.The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased.The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion,spreading,proliferation,and osteogenic differentiation.In addition,Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion.Moreover,the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity,improve new bone formation,and enhance bone-implant integration.This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients. | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu | 2021 | Bioactive Materials2021，6，4： | 4 |
| 3 | Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction显示文摘Osteoclasts ubiquitously participate in bone homeostasis,and their aberration leads to bone diseases,such as osteoporosis.Current clinical strategies by biochemical signaling molecules often perturb innate bone metabolism owing to the uncontrolled management of osteoclasts.Thus,an alternative strategy of precise regulation for osteoclast differentiation is urgently needed.To this end,this study proposed an assumption that mechanic stimulation might be a potential strategy.Here,a hydrogel was created to imitate the physiological bone microenvironment,with stiffnesses ranging from 2.43kPa to 68.2kPa.The impact of matrix stiffness on osteoclast behaviors was thoroughly investigated.Results showed that matrix stiffness could be harnessed for directing osteoclast fate in vitro and in vivo.In particular,increased matrix stiffness inhibited the integrinβ3-responsive RhoA-ROCK2-YAP-related mechanotransduction and promoted osteoclastogenesis.Notably,preosteoclast development is facilitated by medium-stiffness hydrogel(M-gel)possessing the same stiffness as vessel ranging from 17.5 kPa to 44.6 kPa by partial suppression of mechanotransduction,which subsequently encouraged revascularization and bone regeneration in mice with bone defects.Our works provide an innovative approach for finely regulating osteoclast differentiation by selecting the optimum matrix stiffness and enable us further to develop a matrix stiffness-based strategy for bone tissue engineering. | Xiaogang Wang Luli Ji Jing Wang Changsheng Liu | 2023 | Bioactive Materials2023，，9： | 2 |
| 4 | Cholesterol depletion inhibits electrophysiological changes induced by anoxia in CA1 region of rat hippocampal slices 显示文摘 | Rufini S Grossi D Luly P | 2009 | Brain Res2009，1298，： | 1 |
| 5 | Comparison of growth,acetate production,and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations显示文摘 | LULI G W STROHL W R | 1990 | Applied&Environmental Microbiology1990，56，4： | 1 |
| 6 | Hydraulic architecture of deciduous and evergreen dry rainfi~rest tree species from north- eastern Australia 显示文摘 | CHOAT B BALL M C LULY J G | 2005 | Trees-Structure and Function2005，19，： | 1 |
| 7 | A synthesis of protected aminoalkyl epoxides from a-amino acids 显示文摘 | LULY J R DELLARIA J F PLATTNER J J | 1987 | J Org Chem1987，52，8： | 1 |
| 8 | Pit membrane porosity and water stress-induced cavitation in four co-existing dry rainforest tree species显示文摘 | CHOAT B BALL M LULY J | 2003 | Plant Physiology2003，131，： | 1 |
| 9 | Synthesis of protected aminoalkyl epoxides fro- ma-amino acids 显示文摘 | Luly J R | 1987 | J Org Chem1987，52，： | 1 |
| 10 | Sticholysin II: A pore-forming toxin as a probe to recognize sphingomyelin in artificial and cellular membranes显示文摘 | Paloma Sanchez Garcia Gabriele Chieppa Alessandro Desideri Stefano Cannata Elena Romano Paolo Luly Stefano Rufini | 2012 | Toxicon2012，，5： | 1 |
| 11 | Comparison of growth,acetate production,and acetate inhibition ofEscheriohia coli strais in batchh and fed batch fermentations显示文摘 | Luli GW Stroh1 WR | 1990 | Appl Environ Microbiol1990，56，4： | 1 |
| 12 | Glucosestat,a glucose controlled continuonsculture显示文摘 | Kleman GL Chalmers JJ Luli GW | 1991 | Appl enriron Microoiol1991，57，4： | 1 |
| 13 | Polyaniline blends in thermoplastics显示文摘 | Shacklette L M Han C C Luly M H | 1993 | Synth Met1993，57，1： | 1 |
| 14 | Growth and Characterization of LiCoO2 Thin Films for Microbatteries显示文摘 | XiaH LuLi CederG | 2006 | Journal of Alloys and Compounds2006，417，： | 1 |
| 15 | Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations 显示文摘 | Luli G W Strolh W R | 1990 | Applied Environment and Microbiology1990，56，： | 1 |
| 16 | The hemagglutinin envelope protein of canine distemper virus (CDV) confers cell tropism as illustrated by CDV and measles virus complementation analysis显示文摘 | LULI B S GREENBERG M JORNATHAN M G | 1995 | J Virol1995，69，3： | 1 |
| 17 | Electronicstructuresandopticalof(L12,D022)GTiAl3andL12GTi(Al,Pt)3byfirstGprinciplescalculation显示文摘 | DuanYonghua SunYong LuLi | 2013 | JournalofFunctionalMaGterials2013，44，24： | 1 |
| 18 | Influence of soil aggregate size on greenhouse gas emission and uptake rate from tropical peat soil in forest and different oil palm development years显示文摘 | Sonoko D. Kimura Lulie Melling Kah Joo Goh | 2012 | Geoderma2012，，： | 1 |
| 19 | Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF显示文摘 | Laura L Hurley Luli Akinfiresoye Evaristus Nwulia | 2013 | Behav Brain Res2013，239，15： | 1 |
| 20 | Comparison of growth acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations显示文摘 | LULI G W STROHL W R | 1990 | Appl Environ Microbiol1990，36，： | 1 |
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