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| 1 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 2 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 3 | DETERMINATION OF EFFECTIVE MODULI FOR FOAM PLASTICS BASED ON THREE PHASE SPHEROIDAL MODEL显示文摘The relations of bulk modulus,shear modulus,Young’s modulus and the Poisson’s ra-tio with porosity of foam plastics are determined by a three phase spheroidal model commonly used inComposite Mechanics.The results are compared with those using differential scheme.It is shownthat the material properties derived from the present model normally are larger than those obtained bydifferential scheme for foam plastics with identical porosity.The differences in shear moduli andYoung’s moduli obtained by the two methods are small,but they are larger for bulk moduli of incom-pressible matrix and Poisson’s ratios.The Young’s moduli of high density foam plastics derived by thepresent model agree better with experimental ones. | Lu, ZX Huang, ZP Wang, R | 1995 | Acta Mechanica Solida Sinica1995，8，4： | 3 |
| 4 | Effect of HSP70 antisense RNA on normal sorghum pollen formation显示文摘IT has been found that heat shock proteins (hsp) exist universally in animals, plants, microbesand human beings. Some of hsps possess functions of molecular chaperons, such as hsp60,hsp70 and hsp90, which participate in folding and assembling polypeptides to functional struc-tures and transferring them into suitable sites. They also undertake repairing damaged cellularDNA and nucleolus. Therefore, they are house-keeping proteins and play an importantrole in maintaining normal cellular life and functions and in cellular response to environmentalstresses. There exists high homology in DNA sequence among the hsp of the same molecularweight across species. We have first reported the close relationship between hsps | Chen, JN Fu, HY Lu, ZX Qin, HY Zhang, L Guo, ZB | 1997 | Chinese Science Bulletin1997，42，23： | 2 |
| 5 | Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)显示文摘 | Lu H Xi ZX Gitajn L | 2007 | Proc Natl Acad Sci USA2007，104，7： | 1 |
| 6 | Development and characterization of acodominant marker linked to root-knot nematode resistance,and its application to peachrootstock breeding显示文摘 | Lu ZX Sossey-Alaoui K Reighard GL | 1999 | Theor Appl Genet1999，99，： | 1 |
| 7 | Arabinoxylan fibre improves metabolic control in people with Type II diabetes显示文摘 | Lu ZX Walker KZ Muir JG | 2004 | Europ J Clinical Nutrition2004，58，： | 1 |
| 8 | Validation of an algorithm combining haemoglobin A (1c) and fasting plasma glucose for diagnosis of diabetes mellitus in UK and Australian populations 显示文摘 | Manley SE Sikaris KA Lu ZX | 2009 | Diabet Med2009，26，2： | 1 |
| 9 | One-year patency rate of native arteriovenous fistulas reconstructed by vascular strip ping in hemodialysis patients with venous neointimal hyperplasia显示文摘 | Lu FP Liu LP Lu ZX | 2015 | J Vase Surg2015，61，1： | 1 |
| 10 | Effectiveness of interventions for hypeen- sion care in the community-a meta-analvsis of controlled studies in China 显示文摘 | LU ZX Cao SY Chai Y | 2012 | BMC Healh Serv Res2012，12，： | 1 |
| 11 | Adenovirus-mediated siRNA targeting c-Met inhibits proliferation and invasion of small-cell lung cancer(SCLC) cells显示文摘 | Wang ZX Lu BB Yang JS | 2011 | J Surg Res2011，171，1： | 1 |
| 12 | Sythesis of branched polyethylene from ethylene stock by an in- terference- free tandem catalysis of TiClJMgC12 and iron catalyst显示文摘 | Zhang ZC Lu ZX Chen ST | | 0，，： | 1 |
| 13 | Restoration ol uLologous arteriovenous fistula by vascular stripping in a hemo- dialysis patient with venous neointima hyperpasia 显示文摘 | Lu FP Lu ZX Liu X | 2012 | J Vasc Access2012，13，4： | 1 |
| 14 | One-year patency rate of native arteriovenous fistulas reconstructed by vascular stripping in hemodialysis patients with venous neointimal hyperplasia显示文摘 | Lu FP Liu LP Lu ZX | 2015 | J Vase Surg2015，61，1： | 1 |
| 15 | Restoration of autologons arteriovenous fistula by vascular stripping in a hemodialysis patient with venous neointimat hyperplasia显示文摘 | Lu FP Lu ZX Liu X | 2012 | J Vase Access2012，13，4： | 1 |
| 16 | Schistosoma japonicum : A PCR assay for the early detection and evaluation of treatment in a rabbit model显示文摘 | Xia CM Rong R Lu ZX | 2009 | Exp Parasitol2009，121，2： | 1 |
| 17 | Isolation and characterization of a co- producer of fengycins and surfactins, endophytic Bacillus amyloliquefaciens ES- 2, from Scutellaria baicalensis Georgi 显示文摘 | Sun LJ Lu ZX Bie XM | 2006 | World Journal of Microbiology and Biotechnology2006，12，： | 1 |
| 18 | Inhibi-tion of eukaryote protein kinases and of a cyclic nucleotide-bind-ing phosphatase by prenylated xanthones 显示文摘 | LU ZX HASMEDA M MAHABUSARAKAM W | 1998 | Chem Biol Inter-act1998，114，12： | 1 |
| 19 | Schistosoma japonicum : A PCR assay for the early detection and evaluation of treatment in a rabbit model显示文摘 | Xia CM Rong R Lu ZX | 2009 | Exp Parasitol2009，121，： | 1 |
| 20 | Multidrug resistance - associated bi- omarkers PGP, GST - pi, Topo - II and LRP as prognostic factors in primary ovarian earcinoma显示文摘 | Lu D Shi HC Wang ZX | 2011 | Br J Biomed Sci2011，68，2： | 1 |
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