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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | The gene encoding the splicing factor SF2/ASF is a proto-oncogene 显示文摘 | Karni R Stanchina E Lowe W | 2007 | Nat Struct Mol Bioi2007，14，3： | 1 |
| 3 | Variation in open reading frames 3, 4 and 7 among porcine reproductive and respiratory syndrome virus isolates in the UK 显示文摘 | Drew T W Lowings J P Yapp F | 1997 | Vet Microbiol1997，55，14： | 1 |
| 4 | Formation of nitrate and ammonium-ions in titanium-dioxide mediated photocatalytic degradation of organic-compounds compounds containing nitrogen-atoms 显示文摘 | McEvoy S R Matthews R W 1991 | 1991 | Environ Sci Technol1991，25，： | 1 |
| 5 | On the reconfiguration of de- gradable VLSI/WSI arrays显示文摘 | Low C P Leong H W | 1997 | IEEE Trans Comput- er-Aided Design of Integrated Circuits and Systems1997，16，10： | 1 |
| 6 | Evaluating susceptibility of debris flow hazard using multivariate statistical analysis in Hualien Cotmty显示文摘 | SHEN C W LOW C CHEN C Y | 2012 | Disaster Advances2012，5，4： | 1 |
| 7 | Ultrastructure and morphology ofbiofilms on thermoplastic orthodontic appliances in 'fast' and 'slow'plaque formers显示文摘 | Low B Lee W Seneviratne CJ | 2011 | Eur J Orthod2011，33，5： | 1 |
| 8 | Intrinsic tumour suppression显示文摘 | Lowe S Cepero W Evan G | 2004 | Nature2004，432，： | 1 |
| 9 | Uncoupling of metabolism to reduce biomass production in the activated sludge process 显示文摘 | Low E W Chase H A Milner M G | 2000 | Water Res2000，34，12： | 1 |
| 10 | Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases 显示文摘 | LOW P S HENNE W A DOORNEWEERD D D | 2008 | Acc Chem Res2008，41，： | 1 |
| 11 | Heuristic solutions to multidepot location-routing problem显示文摘 | Wu T H Low C Bai J W | 2002 | Computers&Operations Research2002，29，： | 1 |
| 12 | C/EBP transcription factors regulate SREBPlc gene expression during adipogenesis显示文摘 | Payne V A Au W S Lowe C E | 2010 | Biochem J2010，425，1： | 1 |
| 13 | Efficient system reliability analysis illustrated for a retaining wall and a soil slope显示文摘 | LOW B K ZHANG J TANG W H | 2011 | Computers and Geotechnics2011，38，2： | 1 |
| 14 | Thrombolysis for ischemic stroke in the United States:data fromNationa l Hospital Discharge Survey 1999-2001显示文摘 | Suri MF Nasar A He W Kirmani JF Divani AA PrestiqiacomoCJ Low RB | 2005 | Neurosurgery2005，57，65： | 1 |
| 15 | Apoptosis:a link between cancer genetics and chemotherapy显示文摘 | JOHNSTONE R W RUEFLI A A LOWE S W | 2002 | Cell2002，108，： | 1 |
| 16 | Pediatric ethmoidectomy显示文摘 | PRANSKY S M LOW W S | 1996 | Otolaryngol Clio North Am1996，29，1： | 1 |
| 17 | Surface modification of gold nanorods with polymers synthesized by reversible addition-fragmentation chain transfer polymerization 显示文摘 | Hotchkiss J W Lowe A B Boyes S G | 2007 | Chem Mater2007，19，： | 1 |
| 18 | The use of chemical uncouplers for reducing biomass production during biodegradation 显示文摘 | Low E W Chase H A | 1998 | Water Sci Technol1998，37，45： | 1 |
| 19 | In-situ determination of thermal coefficients for electrical machines显示文摘 | Bousbaine A McCormick M Low W F | 1995 | IEEE Transactions of Energy Conversion1995，10，3： | 1 |
| 20 | Measuring depression out- come with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9) 显示文摘 | Lowe B Kroenke K Herzog W | 2004 | J Affect Disord2004，81，： | 1 |
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