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| 1 | P2X7 receptor signaling during adult hippocampal neurogenesis显示文摘Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.Regulation of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature neurons.The expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion dysregulation.Lastly,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease states.Understanding how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative medicine.This review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells. | Hannah C. Leeson Tailoi Chan-Ling Michael D. Lovelace Jeremy C. Brownlie Ben J. Gu Michael W. Weible II | 2019 | Neural Regeneration Research2019，14，10： | 3 |
| 2 | Maximizing Cross-functional New Product Teams' Innovativeness and Constraint Adherence:A Conflict Communications Perspective显示文摘 | Lovelace K Shapiro D L Weingart L R | 2001 | Academy of Management Journal2001，44，4： | 1 |
| 3 | Relativistic Hartree condition for magnetrons:Theory and comparison with experiments显示文摘 | Lovelace R V Young T F T | 1985 | Phys Fluids1985，28，8： | 1 |
| 4 | Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure显示文摘 | Lovelace TW Henry MA Hargreaves KM | 2011 | J Endod2011，37，2： | 1 |
| 5 | Maximizing cross-functional new product teams' innovativeness and constraint adherence : a conflict communications perspective 显示文摘 | LOVELACE K SHAPIRO D L WEINGART L R | 2001 | Academy of Management Journal2001，44，4： | 1 |
| 6 | Measuring central corneal thickness with ultrasound pachymetry 显示文摘 | Realini T Lovelace K | 2003 | Optam Vis Sci2003，80，6： | 1 |
| 7 | Maximizing Cross-Functional New Product Teams' Innovativeness and Constraint Adherence:A Conflict Communications Perspective显示文摘 | LOVELACE K SHAPIRO D L WEINGART L R | 2001 | Academy of Management Journal2001，44，4： | 1 |
| 8 | Maximizing Cross - Func- tional New Product Teams' Innovativeness and Con- straint Adherence显示文摘 | Lovelace K Weingart LR | 2001 | Academy of Management Jour- nal2001，44，4： | 1 |
| 9 | The floppy head syndrome (abstract)显示文摘 | Lange DJ Fetell MR Lovelace R E | 1986 | Ann Neurol1986，20，： | 1 |
| 10 | Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure显示文摘 | Lovelace TW Henry MA Hargreaves KM Diogenes A | 2011 | Journal of endodontics2011，37，2： | 1 |
| 11 | Evaluation of the delivery of mesenchymal stem ceils into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure 显示文摘 | Lovelace TW Henry MA Hargreaves KM | 2011 | J Endod2011，37，2： | 1 |
| 12 | Experimental study of two-pahse propane expanded through the Ranque-Hilsch tube显示文摘 | Lovelace | 1979 | Journal of Heat Transfer ASME1979，101，5： | 1 |
| 13 | The sympathetic skin response: normal values, elucidation of afferent components and application limits显示文摘 | Uncini A Pullmann SL Lovelace RE | 1988 | J Neurol Sci1988，87，： | 1 |
| 14 | Measuring central corneal thickness with ultrasound pachymetry 显示文摘 | Realini T Lovelace K | 2003 | Optam Vis Sci2003，80，6： | 1 |
| 15 | Maximizing Cross Functional New Product Teams Innovativeness and Constraint Adherence : A Conflict Communications Perspective 显示文摘 | LOVELACE K SHAPIRO D L WEINGART L R | 2001 | Academy of Management Journal2001，44，4： | 1 |
| 16 | Crystal structure of complement protein C8garoma in complex with a peptide containing the CSgmnma binding site on C8apha:implications for CSgamma ligand binding显示文摘 | Lovelace LL Chiswell B Slade DJ | 2008 | Mol Immunol2008，45，3： | 1 |
| 17 | Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans显示文摘 | Lovelace TB Mellonig JT Meffert RM | 1998 | J Periodontal1998，69，9： | 1 |
| 18 | Integrating sensory integration显示文摘 | Lovelace Christopher T Partan Sarah | 2001 | Trends in Cognitive Sciences2001，5，2： | 1 |
| 19 | Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure显示文摘 | Lovelace TW Henry MA Hargreaves KM | 2011 | J Endod2011，37，2： | 1 |
| 20 | Maximizing cross- functional new product teams' innovativeness and constraint adherence: A conflict communications per spective显示文摘 | LOVELACE K SHAPIRO D L WEINGART L R | 2001 | Academy of Management Journal2001，44，4： | 1 |
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