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| 1 | Coordinated AR and microRNA regulation in prostate cancer显示文摘The androgen receptor(AR)remains a key driver of prostate cancer(PCa)progression,even in the advanced castrate-resistant stage,where testicular androgens are absent.It is therefore of critical importance to understand the molecular mechanisms governing its activity and regulation during prostate tumourigenesis.MicroRNAs(miRs)are small w22 nt noncoding RNAs that regulate target gene,often through association with 30 untranslated regions(30UTRs)of transcripts.They display dysregulation during cancer progression,can function as oncogenes or tumour suppressors,and are increasingly recognised as targets or regulators of hormonal action.Thus,understanding factors which modulate miRs synthesis is essential.There is increasing evidence for complex and dynamic bi-directional cross-talk between the multi-step miR biogenesis cascade and the AR signalling axis in PCa.This review summarises the wealth of mechanisms by which miRs are regulated by AR,and conversely,how miRs impact AR’s transcriptional activity,including that of AR splice variants.In addition,we assess the implications of the convergence of these pathways on the clinical employment of miRs as PCa biomarkers and therapeutic targets. | Ieva Eringyte Joanna N.Zamarbide Losada Sue M.Powell Charlotte L.Bevan Claire E.Fletcher | 2020 | Asian Journal of Urology2020，7，3： | 2 |
| 2 | Experience with the surgical treatment of hepatic hydatidosis: Case series with follow-up显示文摘AIM: To describe patient characteristics and the results of surgical treatment for hepatic hydatidosis (HH) in the Hospital Hernán Henríquez Aravena from December 2001 to March 2005. METHODS: Subjects older than 16 years with suspected HH were included based on the clinical picture and radiological studies. Variables examined included clinical and laboratory aspects, outcome, features of the parasite and surgical aspects. Descriptive statistics were used, calculating central tendency, dispersion and extreme tendency. RESULTS: The series was comprised of 122 patients, with an average age of 44 ± 16.9 years. The most frequently used surgical technique was subtotal cys-tectomy in 90% of the patients, followed by hepatic resection (hepatectomy, segmentectomy and subsegmentectomy) in 5%. In 2%, a combination of subtotal cystectomy and segmentectomy was performed. In addition, 28% of the series presented complications in the postoperative period and mortality was 2%. CONCLUSION: The most frequently used surgical technique for HH was subtotal cystectomy and the morbidity and mortality rates in this Chilean series are comparable to other national and international series. | Hector Losada Morales Luis Burgos San Juan Jorge Silva Abarca Cesar Muoz Castro | 2010 | World Journal of Gastroenterology2010，16，26： | 2 |
| 3 | Growth Effects of an Un- funded social Security System When there is Altruism and Human Capital 显示文摘 | Fernando Sanchez Losada | 2002 | Eco-nomics Letters2002，，69： | 1 |
| 4 | The sacrum : pathologic spectrum, and subspecialty approach 显示文摘 | Diel J Ortiz O Losada RA | 2001 | Radiographics2001，34，1： | 1 |
| 5 | Mode coupling contribution to radiation losses in curvaturesfor high and low numerical aperture plastic optical fibers 显示文摘 | Losada M A Garces Mateo J | 2002 | Lightwave Technology2002，20，7： | 1 |
| 6 | Numerical analysis of wave overtopping of rubble mound breakwaters显示文摘 | Losada I J Lara J L Guanchea R Gonzalez-Ondina J M | 2008 | Coastal Engineering2008，55，1： | 1 |
| 7 | Papulonecrotic tuberculid显示文摘 | Losada A Garcia-Sanz MT Varela-Duran J | | 0，，01： | 1 |
| 8 | The Impact of Ageing on theTourism Industry : An Approach to the Senior TouristProfile显示文摘 | Elisa Alen Nieves Losada | 2016 | Social Indicators Research2016，，1： | 1 |
| 9 | Improvement of the commer-cial quality of chilled Norway lobster(Nephrops norvegicus) stored inslurry ice: Effects of a preliminary treatment with an antime -lanosic agent on enzymatic browning显示文摘 | Aubourg S P Losada V Prado M | 2007 | Food Chemistry2007，103，： | 1 |
| 10 | Ferrocenyl and permethylferrocenyl cyclic and polyhedral siloxane poly- mers as mediators in amperometric biosensors 显示文摘 | LOSADA J ARMADA M P G CUADRADO I | 2004 | J Organomet Chem2004，689，17： | 1 |
| 11 | The prediction of apparent metabolisable ener- gy content of oil seeds and oil seed by-products for poultry from its chemical components, in vitro analysis or near-infrared reflectance spectroscopy 显示文摘 | LOSADA B GARdA REBOLLAR P LVAREZ C | 2010 | Animal Feed Science and Technology2010，160，12： | 1 |
| 12 | Enzymatic systems of inorganic pyrophosphate bioenergetics in photosynthetic and heterotrophic protists:remnants or metabolic cornerstones显示文摘 | Perez-Castineira J R Gomez-Garcia R Lopez-Marques R L Losada M Serrano A | | 0，，03： | 1 |
| 13 | Effect of pre- soaking whole pelagic fish in a plant extract on sensory and biochemical changes during subsequent frozen stor- age显示文摘 | Lugasi A Losada V H6v6ri - LWT J | 2007 | LWT - Food Science and Technology2007，40，5： | 1 |
| 14 | Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis:the asparaginyl endopeptidase(Sm32)显示文摘 | Chacon N Losada S Bermudez H | 2003 | Immunol Lett2003，88，3： | 1 |
| 15 | Towards a healthierdiet for the colon:the influence of fructooligosaccharides and lactobacilli on intestinal health 显示文摘 | LOSADA M A OLLEROS T | 2002 | Nutrition Research2002，22，： | 1 |
| 16 | Biomagnification of anthropogenic and naturally-produced organo brominated compounds in a marine food web from Sydney Harbour, Australia 显示文摘 | Losada S Roach A Roosens L | 2009 | Environment International2009，35，8： | 1 |
| 17 | Comparative biochemical and functional studies of family Ⅰ soluble inorganic pyrophosphatases from photosynthetic bacteria显示文摘 | Gómez-García M R Losada M Serrano A | | 0，，15： | 1 |
| 18 | Response of processing tomato to three different levels of water and nitrogen applications 显示文摘 | YRISARRY J J B LOSADA M H P RINCON A R 13 | 1993 | Acta Horticulturae1993，335，： | 1 |
| 19 | Diffusion-weighted MRI for quantification of liver fibrosis:preliminary experience显示文摘 | Taouli B Tolia AJ Losada M | 2007 | AJR2007，189，4： | 1 |
| 20 | Modelling of wave loads and hydraulic performance of vertical permeable structures 显示文摘 | REQUEJO S VIDAL C LOSADA I | 2002 | Coastal Eng2002，46，4： | 1 |
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