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| 1 | The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism显示文摘Histone deacetylase 3 (HDAC3) is a major HDAC, whose enzymatic activity is targeted by small molecule inhibitors for treating a variety of conditions. However, its enzymatic activity is largely dispensable for its function in embryonic development and hepatic lipid metabolism.HDAC3 plays a pivotal role in regulating muscle fuel metabolism and contractile function. Here, we address whether these muscular functions of HDAC3 require its enzymatic activity. By mutating the NCoR/SMRT corepressors in a knock - in mouse model named NS-DADm, we ablated the enzymatic activity of HDAC3 without affecting its protein levels. Compared to the control mice, skeletal muscles from NS-DADm mice showed lower force generation, enhanced fatigue resistance, enhanced fatty acid oxidation, reduced glucose uptake during exercise, upregulated expression of metabolic genes involved in branchedchain amino acids catabolism, and reduced muscle mass during aging, without changes in the muscle fiber-type composition or mitochondrial protein content. These muscular phenotypes are similar to those observed in the HDAC3-depleted skeletal muscles, which demonstrates that, unlike that in the liver or embryonic development, the metabolic function of HDAC3 in skeletal muscles requires its enzymatic activity. These results suggest that drugs specifically targeting HDAC3 enzyme activity could be developed and tested to modulate muscle energy metabolism and exercise performance. | Shiyan Song Yefei Wen Hui Tong Emanuele Loro Yingyun Gong Jidong Liu Sungguan Hong Lei Li Tejvir S.Khurana Maoping Chu Zheng Sun | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 2 | 是,生理节奏的节奏实际上确实影响几乎一切显示文摘 | Jay C Dunlap Jennifer J Loros | 2016 | Cell Research2016，26，7： | 3 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice 显示文摘 | Casimiro MC Crosariol M Loro E | 2012 | J Clin Invest2012，122，3： | 1 |
| 5 | Waveletes and wideband correlation processing显示文摘 | LORO G WEISS | 1994 | IEEE Signal Processing Magazine1994，11，13： | 1 |
| 6 | The PAS protein VIVID defines aclock-associated feedback loop that represses light input,modulates gating,andregulates clock resetting显示文摘 | Heintzen C Loros J J Dunlap J C | 2001 | Cell2001，104，3： | 1 |
| 7 | Vertebral size in elderly women with osteoporosis显示文摘 | Gilsanz V Loro ML Roe TF | 1995 | J Clin Invest1995，95，5： | 1 |
| 8 | Preliminary studies of analgesic and anti-inflammatory properties of Opuntia dillenii aqueous extract 显示文摘 | J F Loro I del Rio L Pérez-Santana | 1999 | Journal of Ethnopharmacology1999，67，： | 1 |
| 9 | ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice显示文摘 | Casimiro MC Crosariol M Loro E | | 0，，03： | 1 |
| 10 | White collar- 1,a circadian blue light photoreceptor,binding to the frequency promoter显示文摘 | FROEHLICH A C LIU Y LOROS J J | 2002 | Science2002，297，5582： | 1 |
| 11 | Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma显示文摘 | Loro L L Vintermyr O K Johannessen A C | 1999 | J Oral Pathol Med1999，28，2： | 1 |
| 12 | Negative feedback defining a circadian clock: autoregulation of the clock gene frequency显示文摘 | Aronson B D Johnson K A Loros J J | 1994 | Science1994，263，： | 1 |
| 13 | The PAS/LOV protein VIVID supports a rapidly dampened daytime oscillator that facilitates entrainment of the Neurospora circadian clock 显示文摘 | ELVIN M LOROS J J DUNLAP J C | 2005 | Genes & Development2005，19，： | 1 |
| 14 | ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal insta- bility in mice显示文摘 | Casimiro MC Crosariol M Loro E | 2012 | J Clin Invest2012，122，3： | 1 |
| 15 | Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates显示文摘 | Loro E Gianazza E Cazzola S | | 0，，12： | 1 |
| 16 | Inhibition of mitochondrial fi ssion favours mutant over wild-type mitochondrial DNA 显示文摘 | Malena A Loro E Di RM | 2009 | Hum Mol Genet2009，18，18： | 1 |
| 17 | Molecular bases for circadian clocks显示文摘 | Dunlap J C Loros J J | 1999 | Cell1999，96，2： | 1 |
| 18 | Diversi ty and composition of fungal endophytes in semiarid Northwest Ver, czuela显示文摘 | Loro M Valero-Jim6nez C A Nozawa S | 2012 | J Arid Environ2012，85，： | 1 |
| 19 | Cyclins and cell cycle control in cancer and disease 显示文摘 | Casimiro MC Crosariol M Loro E | 2012 | Genes Cancer2012，3，1112： | 1 |
| 20 | No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma显示文摘 | Bacci G Loro L Longhi A | 2006 | Anticancer Drugs2006，17，4： | 1 |
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