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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 3 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 4 | Polymerization of vinyl acetate in ternary microemulsions stabilized with hexadecyhrimethylammonium bromide显示文摘 | LOPEZ R G TREVINO M E SALAZAR L V | 1997 | Polymer Bulletin1997，38，4： | 1 |
| 5 | CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells显示文摘 | Lopez R D Waller E K Lu P H | 2001 | Cancer Immunol Immunother2001，49，12： | 1 |
| 6 | Streptococcus pneumoniae type 3 encodes a protein highly similar to the human glutamate decarboxylase (GAD65) 显示文摘 | GARCIA E LOPEZ R | 1995 | FEMS Microbiol Lett1995，133，12： | 1 |
| 7 | Transformerless Single-Phase Multilevel-Based Photovohaic Inverter 显示文摘 | Gonzalez R Gubia E Lopez J Marroyo L | 2008 | IEEE Transactions on Industrial Electronics2008，55，7： | 1 |
| 8 | Isolation of Resistance Gene Candidates (RGCs) and characterization of an RGC cluster in cassava显示文摘 | Lopez C E Zuluaga A P Cooke R | 2003 | Molecular Genetics and Genomics2003，269，5： | 1 |
| 9 | Different configurations for the early description of Escherichia coli activity through dynamic speckles显示文摘 | Miquet E E R Lopez L M Alarcon O R C | 2011 | Rev Mex Fis2011，57，5： | 1 |
| 10 | Purification and characterization of a galactose-specific lectin from Psilocybe barrerae显示文摘 | Ortiz R Lopez F | 1993 | Phytochemistry1993，32，5： | 1 |
| 11 | Phage Lytic Enzymes as Therapy for Antibiotic - resistant Streptococcus Pneumoniae Infection in a Murine,Sepsis,Model显示文摘 | Jado I R Lopez E Garcia | 2003 | J Antimic - rob Chemother2003，52，： | 1 |
| 12 | Size effects in the structural phase transition of V02 nanoparticles 显示文摘 | LOPEZ R HAYNES T E BOATNER L A | 2002 | Phys Rev B2002，65，22： | 1 |
| 13 | 17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription显示文摘 | Rodriguez E Lopez R Paez A | 2002 | Life Sci2002，71，18： | 1 |
| 14 | Preparation of TiO2-ZrO2 mixed oxides with controlled acid-basic properties显示文摘 | Manqfiuez M E Lopez T Gomez R | 2004 | Mol Catal A:Chem2004，220，2： | 1 |
| 15 | Biological roles of two new murein hydrolases of Streptococcus pneumoni- ae representing examples of module shuffling显示文摘 | Lopez R Gonzalez MP Garcia E | 2000 | Research in Microbiology2000，151，6： | 1 |
| 16 | Cardiac mass and function,carotid artery intima-media thickness,and lipoprotein levels in growth hormone-deficient adolescents显示文摘 | Lanes R Gunczler P Lopez E | 2001 | J Clin Endocrinol Metab2001，86，3： | 1 |
| 17 | Combining stereo vision and inertial navigation system for a quad-rotor uav显示文摘 | Garcia Carrillo L R Dzul Lopez A E Lozano R | 2012 | Journal of Intelligent & Robotic Systems2012，65，14： | 1 |
| 18 | Is dissection of level IV necessary in patients with T1, -T3 NO tongue cancer? 显示文摘 | KHAFIF A LOPEZ GARZA J R MEDINA J E | 2001 | Laryngoscope2001，111，6： | 1 |
| 19 | Transcystic common bile duct exploration in the management of patients with choledocholithiasis显示文摘 | Rojas Ortega S Arizoe Bravo D Marin Lopez E R | 2003 | J Gastrointest Surg2003，7，4： | 1 |
| 20 | Chimeric phage-bacterial enzymes: a clue to the modular evolution of genes显示文摘 | Diaz E Lopez R GarciaJL | 1990 | Proceedings of the National Academy of Sciences of the United States of America1990，87，20： | 1 |
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