|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis显示文摘AIM:To ascertain the usefulness of a histological scoring system devised to assist in the interpretation of liver histology in neonatal cholestasis(NC) .METHODS:Liver biopsy specimens obtained from infants with NC referred to a tertiary pediatric unit in Malaysia were prospectively studied.The first author,blinded to the final diagnosis,devised the histological diagnosis based on a 7-feature(portal ductal proliferation,bile plugs in portal ductules,portoportal bridging,lymphocytic infiltration in portal region,multinucleated hepatocytes,neutrophilic infiltration,hepatocellular swelling) ,15-point(0 to 15) scoring system.The author classified the histological diagnosis as either biliary atresia(BA) or neonatal hepatitis(NH,all other diagnoses) ,and subsequently compared the author's diagnosis with the final diagnosis.RESULTS:Eighty-four biopsy specimens obtained from 78 patients were reviewed.Without the scoring system,BA was correctly diagnosed by the author histologically in 30 cases,labelled as NH in 3.For other diagnoses,BA was excluded correctly in 33 cases and mislabeled as BA in 2 cases.The overall sensitivity for BA was 91%,specificity 86% and accuracy 88%.With the scoring system,a score of ≥ 7 had the best diagnostic utility to differentiate BA from other intrahepatic cholestasis histologically(sensitivity 88%,specificity 94%,accuracy 92%) .Four patients with a score < 7 had BA,and 3 patients with a score ≥ 7 had NH.CONCLUSION:A 7-feature,15-point histological scoring system had good diagnostic accuracy in the interpretation of liver histology in neonatal cholestasis. | Way Seah Lee Lai Meng Looi | 2009 | World Journal of Gastroenterology2009，15，42： | 11 |
| 2 | 采用柠檬酸合成高分散铜催化剂用于选择氢解反应(英文)显示文摘A highly dispersed Cu catalyst supported on silica was prepared by an incipient wetness impregnation method with citric acid.The synthesis was studied by nitrogen physisorption,X-ray diffraction,and temperature-programmed reduction by comparing with a reference prepared without citric acid.The catalyst precursor obtained after impregnation was X-ray amorphous.The precursor was readily transformed to crystalline CuO upon calcination.The CuO particles were of uniform size in a highly dispersed state and can be reduced to Cu at a lower temperature.The activity of the Cu catalyst obtained was an order of magnitude higher than that of the reference for the hydrogenolysis of methyl laurate to dodecanol. | Ming-Hoong LOOI Shuk-Tong LEE Sharifah Bee ABD-HAMID | 2008 | 催化学报2008，29，6： | 8 |
| 3 | Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis显示文摘There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain controversial.We have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic stroke.Relevant studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the analysis.There was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically insignificant.In stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random errors.Limitations of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from meta-analysis.In conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of stroke.Nevertheless,vitamin E may offer some benefits in the prevention of ischaemic stroke and additional well-designed randomised controlled trials are needed to arrive at a definitive finding.PROSPERO registration number:CRD42020167827. | Hong Chuan Loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 4 | Hydroxychavicol,a polyphenol from Piper betle leaf extract,induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells显示文摘This study aims to elucidate the antiproliferative mechanism of hydroxychavicol(HC).Its effects on cell cycle,apoptosis,and the expression of c-Jun N-terminal kinase(JNK)and P38 mitogen-activated protein kinase(MAPK)in HT-29 colon cancer cells were investigated.HC was isolated from Piper betle leaf(PBL)and verified by high-performance liquid chromatography(HPLC),nuclear magnetic resonance(NMR),and gas chromatography-mass spectrometry(GC-MS).The cytotoxic effects of the standard drug 5-fluorouracil(5-FU),PBL water extract,and HC on HT-29 cells were measured after 24,48,and 72 h of treatment.Cell cycle and apoptosis modulation by 5-FU and HC treatments were investigated up to 30 h.Changes in phosphorylated JNK(pJNK)and P38(pP38)MAPK expression were observed up to 18 h.The half maximal inhibitory concentration(IC_(50))values of HC(30μg/mL)and PBL water extract(380μg/mL)were achieved at 24 h,whereas the IC_(50)of 5-FU(50μmol/L)was obtained at 72 h.Cell cycle arrest at the G0/G1 phase in HC-treated cells was observed from12 h onwards.Higher apoptotic cell death in HC-treated cells compared to 5-FU-treated cells(P<0.05)was observed.High expression of pJNK and pP38 MAPK was observed at 12 h in HC-treated cells,but not in 5-FU-treated HT-29 cells(P<0.05).It is concluded that HC induces cell cycle arrest and apoptosis of HT-29 cells,with these actions possibly mediated by JNK and P38 MAPK. | Aiysvariyah RAJEDADRAM Kar Yong PIN Sui Kiong LING See Wan YAN Mee Lee LOOI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 2 |
| 5 | pS2 expression in infiltrating ductal carcinoma of the breast correlates with oestrogen receptor positivity but not with histological grade and lymph node status显示文摘 | Azura W W Cheah P L | 2001 | Pathology2001，33，3： | 1 |
| 6 | Rapid and synchronous collapse of marine and terrestrial ecosystems during the end-Permian biotic crisis显示文摘 | Twitchett R J Looy C V Morante R | 2001 | Geology2001，29，： | 1 |
| 7 | The effects of two contrasting forms of orthodontic treatment on the facial profile显示文摘 | Looi L Mills JRE | 1986 | Am J Orthod1986，89，5： | 1 |
| 8 | Use of 3-dimensional printing technology and silicone modeling in surgical simulation: development and face validation in pediatric laparoscopic pyelo- plasty 显示文摘 | Cheung CL Looi T Lendray TS | 2014 | J Surg Educt2014，71，5： | 1 |
| 9 | Plasma proteome anal- ysis of cervical intraepithelial neoplasia and cervical squamous cell carcinoma显示文摘 | Looi M L Karsani S A Rahman M A | 2009 | Biosci2009，34，： | 1 |
| 10 | Understanding mobile learning from the perspective of self - regulated learning 显示文摘 | Sha L& Looi CK | 2012 | Journal Of Computer Assisted Leaming2012，，28： | 1 |
| 11 | Combined assessment of TGF-betal and alpha-fetoprotein values improves specificity in the diagnosis of hepatocellular carcinoma and other chronic liver diseases in Malaysia显示文摘 | Yasmin-Anum MY Looi ML Nor-Aini AH | | 0，，04： | 1 |
| 12 | Vincristine-resistant Kasabach-Merritt phenomenon successfully treated with low-dose radiotherapy显示文摘 | Watanabe Y Onuma M Looi CY | | 0，，01： | 1 |
| 13 | Traces of prior art : an analysis of non - patent references found in patent documents显示文摘 | Callaert J Van Looy B Verbeek A Debackere K Thijs B | 2006 | Scientometrics2006，69，1： | 1 |
| 14 | Exploring the feasibility and accuracy of latent semantic analysis based text mining techniques to detect similarity between patent documents and scientific publieations显示文摘 | MAGERMAN T VAN LOOY B SONG X Y | 2010 | Seiento- metrics2010，82，2： | 1 |
| 15 | Baseline metals pollution profile of tropical estuaries and coastal waters of the Straits of Malacca显示文摘 | Looi L J Aris A Z Johari W L W | 2013 | Marine Pollution Bulletin2013，74，1： | 1 |
| 16 | The Impact of Collaboration on the Technological Performance of Regions:Time Invariant or Driven by Life Cycle Dynamics?显示文摘 | Lecocq C Looy B V | 2009 | Scientometrics2009，80，3： | 1 |
| 17 | Towards a conceptual framework for assessing the effectiveness of digital game- based learning显示文摘 | All A Nu Ez Castellar E P Van Looy J | 2015 | Computers & Education2015，88，： | 1 |
| 18 | Tfiple-negative breast cancer and PTEN (phosphatase and tensin homologue) loss are predictors of BRCA 1 germline mutations in women with early-onset and famil- ial breast cancer,but not in women with isolated late-onset breast cancer显示文摘 | Phuah SY Looi LM Hassan N | 2012 | Breast Cancer Res2012，14，6： | 1 |
| 19 | Drying kinetics of single porous particles in superheated steam under pressure显示文摘 | LOOI A Y GOLONKA K RHODES M | 2002 | Chemical Engineering Journal2002，87，： | 1 |
| 20 | Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer显示文摘 | Zhang J Y Looi K S Tan E M | 2009 | Methods Mol Biol2009，520，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员