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| 1 | Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy. | Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 3 |
| 2 | Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein显示文摘 | Looby M Ibarra N Pierce J J | | 0，，06： | 1 |
| 3 | Percutaneous Ultrasound-Guided Thrombin Injection as First-Line Treatment of Pancreatic Pseudoaneurysm显示文摘 | Aoife McErlean Seamus Looby Michael J. Lee | 2007 | CardioVascular and Interventional Radiology2007，，3： | 1 |
| 4 | Airway analysis:with bilateral distraction of the infant mandible显示文摘 | Looby JF Schendel SA Lorenz HP | 2009 | J Craniofac Surg2009，20，5： | 1 |
| 5 | Incidence and patterns of polydrug use and craving for ecstasy in regular ecstasy users:an ecological momentary assessment study显示文摘 | Hopper JW Su Z Looby AR | 2006 | Drug Alcohol Depend2006，85，： | 1 |
| 6 | Spine trauma显示文摘 | Looby S Flanders A | 2011 | Radiol Clin North Am2011，49，： | 1 |
| 7 | Application of quality by design principles to the development and technology transfer of a major process improvement for the manufacture of a recombinant protein显示文摘 | Looby M Ibarra N Pierce JJ | 2011 | Biotechnol Prog2011，27，6： | 1 |
| 8 | Relationship Between Neck Circ- umference and Cardiometabolic Parameters in HIV~Infected and Non-HIV-Infected Adults 显示文摘 | Fitch KV Stanley TL Looby SE | 2011 | Diabetes Care2011，34，4： | 1 |
| 9 | Fixed bed porous glass sphere(porosphere)bioreactors for animal cells显示文摘 | Looby D Griffiths JB | 1988 | Cytotechnology1988，1，4： | 1 |
| 10 | Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS显示文摘Normothermic ex vivo lung perfusion(NEVLP)has emerged as a modernized organ preservation technique that allows for detailed assessment of donor lung function prior to transplantation.The main goal of this study was to identify potential biomarkers of lung function and/or injury during a prolonged(19 h)NEVLP procedure using in vivo solid-phase microextraction(SPME)technology followed by liquid chromatography-high resolution mass spectrometry(LC-HRMS).The use of minimally invasive in vivo SPME fibers for repeated sampling of biological tissue permits the monitoring and evaluation of biochemical changes and alterations in the metabolomic profile of the lung.These in vivo SPME fibers were directly introduced into the lung and were also used to extract metabolites(on-site SPME)from fresh perfusate samples collected alongside lung samplings.A subsequent goal of the study was to assess the feasibility of SPME as an in vivo method in metabolomics studies,in comparison to the traditional inlab metabolomics workflow.Several upregulated biochemical pathways involved in pro-and antiinflammatory responses,as well as lipid metabolism,were observed during extended lung perfusion,especially between the 11th and 12th hours of the procedure,in both lung and perfusate samples.However,several unstable and/or short-lived metabolites,such as neuroprostanes,have been extracted from lung tissue in vivo using SPME fibers.On-site monitoring of the metabolomic profiles of both lung tissues through in vivo SPME and perfusate samples on site throughout the prolonged NEVLP procedure can be effectively performed using in vivo SPME technology. | Nikita Looby Anna Roszkowska Aadil Ali Barbara Bojko Marcelo Cypel Janusz Pawliszyn | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 1 |
| 11 | Incidence andpatterns of polydrug use and craving for ecstasy in regularecstasy users:an ecological momentary assessment study显示文摘 | Hopper J W Su Z Looby A R | 2006 | Drug Alcohol Depend2006，85，3： | 1 |
| 12 | Perioperative nursing documentation in liver transplantation显示文摘 | Looby M Flynn M | 1998 | Br J Theatre Nuts1998，8，4： | 1 |
| 13 | Relationship between neck circumfference and cardiometabolic parameters in HIV-infected and non-HIV-infected adults显示文摘 | Fitch KV Stanley TL Looby SE | | 0，，： | 1 |
| 14 | Popu-lation pharmacokinetics and optimal design of paediatric studies for famciclovir显示文摘 | OGUNGBENRO K MATTHEWS I LOOBY M | 2009 | Br J Clin Pharmacol2009，68，4： | 1 |
| 15 | Relationship between neck circumference and cardiometabolic parame- ters in hiv-infected and non-hiv-infected adults 显示文摘 | Fitch K V Stanley T L Looby S E | 2011 | Dia- betes Care2011，34，4： | 1 |
| 16 | Childhood attention deficit hyperactivity disorder and the development of substance use disorders: valid concern or exaggeration显示文摘 | Looby A | 2008 | Addict Behav2008，33，3： | 1 |
| 17 | Relationship between neck circumference and cardiometabolic parameters in HIV-infec- ted and non-HIV-infected adults 显示文摘 | Fitch K V Stanley T L Looby S E | 2011 | Diabetes Care2011，34，4： | 1 |
| 18 | Perioperative nursing documentatipn in liver transplantation显示文摘 | LOOBY M FLYNN M | 1998 | Br J Theatre Nurs1998，8，4： | 1 |
| 19 | Labeling a Hydrazine Nicotinamide-Modified Cyclic Ⅱb/Ⅲa Receptor Antagonist With ^99Tc^m Using Aminocarboxylates as Coligands显示文摘 | Liu S Edwards D S Looby R J | 1996 | Bioconjugate Chem1996，7，： | 1 |
| 20 | EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus显示文摘 | Overoye-Chan K Koerner S Looby RJ | 2008 | J Am Chem Soc2008，130，18： | 1 |
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