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| 1 | SQUAMOSA Promoter-Binding Protein-Like Transcription Factors:Star Players for Plant Growth and Development显示文摘SQUAMOSA Promoter-Binding Protein-Like (SPL) genes encode plantspecific transcription factors that play important roles in plant phase transition,flower and fruit development,plant architecture,gibberellins signaling,sporogenesis,and response to copper and fungal toxins.In Arabidopsis,many SPL genes are post-transcriptionally regulated by the microRNA (miRNA) miR156,among which AtSPL9 in turn positively regulates the expression of the second miRNA miR172.This miR156AtSPL9-miR172 regulatory pathway plays critical roles during juvenile to adult leaf development and the miR156-SPLs feedback interaction persists all through the plant development,which may be conserved in other plants.In the present paper,we provide a concise review on the most recent progress in the regulatory mechanisms associated with plant SPL transcription factors,especially in relation to miRNAs.The potential application of these discoveries in agriculture is briefly discussed. | Xiaobo Chen Zenglin Zhang Danmei Liu Kai Zhang Aili Li Long Mao | 2010 | Journal of Integrative Plant Biology2010，52，11： | 31 |
| 2 | Genome Editing and Double-Fluorescence Proteins Enable Robust Maternal Haploid Induction and Identification in Maize显示文摘 | Le Dong Lina Li Changlin Liu Chenxu Liu Shuaifeng Geng Xinhai Li Changling Huang Long Mao Shaojiang Chen Chuanxiao Xie | 2018 | Molecular Plant2018，11，9： | 22 |
| 3 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 4 | Evolution of plant microRNA gene families显示文摘MicroRNAs (miRNAs ) 是他们在植物和动物的目标基因的重要 post-transcriptional 管理者。miRNAs 通常长是 20-24 核苷酸。尽管有他们的不平常地小的尺寸, miRNA 基因家庭的进化历史似乎类似于编码 theirprotein 对应物。与在动物染色体的小却丰富的 miRNA 家庭相对照,植物有少数但是更大的 miRNA 基因家庭。植物 miRNA 基因家庭的成员经常是高度类似的,建议经由双人脚踏车基因复制和部分复制事件的最近的扩大。尽管许多 miRNA 基因越过植物种类被保存,一样的基因家庭在不同种类在尺寸和 genomic 组织显著地变化,它可以在目标基因规定引起剂量效果和空间、时间的差别。在这评论,我们在理解植物 miRNA 基因家庭的进化总结当前的进步。 | Aili Li Long Mao | 2007 | Cell Research2007，17，3： | 13 |
| 5 | Mechanomics: an emerging field between biology and biomechanics显示文摘在 vivo 各种各样的房间感觉机械刺激,它开始到机械力量的下游的发信号。当证据的身体在过去的十年在有限机械管理者的影响上被介绍时,机制 biomechanical 回答怎么全球性影响房间函数需要被探讨。复杂性和差异在 vivo,机械线索介绍不同模式砍有它的大小,持续时间,或频率的各种各样的参量的联合的流动,张力的段,或机械压缩。因此,理解被要求,从 mechanobiology 的观点,房间的机械特征是什么,机械性质为什么,并且怎么在不同房间类型之中是不同的力量是到下游地生物化学的信号的 transduced。同时,那些通常在 vivo 一起在孤立的机械刺激是的 vitro 联合了,建议是的不同因素能个别地实际上被抵销或与对方一起安排了。显然, omics 分析,系统生物学的地里的一个强大的工具,是有益的与 mechanobiology 结合然后印射它的染色体编码的机械地敏感的蛋白质和抄本完整集合。这块新出现地,也就是 mechanomics,使阐明可能在系统地变化的机械刺激下面的全球回答。这评论在 mechanomics 的相关的地里讨论当前的进展并且详细描述房间怎么察觉到外部力量并且激活生物回答。 | Jiawen Wang Dongyuan Lu Debin Mao Mian Long | 2014 | Protein & Cell2014，5，7： | 12 |
| 6 | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells显示文摘Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460,AS49 and H157 were cultured in vitro.The cytotoxic activities were determined using MTT assay.The apoptotic cells death was examined by flow cytometry using PI staining and DMA agarose gel electrophoresis.The activities of caspase-3, -8 and -9 were measured via ELISA.Cellular fractionation was determined by flow cytometry to assess release of cytochrome c and the mitochondrial transmembrane potential.Bcl-2/Bcl-XL/ XIAP/Bid/ DR5 and DR4 proteins were analyzed using western blot.Results:The concentrations required for a 50%decrease in cell growth(IC50) ranged from 1.8 to 3.2 Jt M.Casticin induced rapid apoptosis and triggered a series of effects associated with apoptosis by way of mitochondrial pathway,including the depolarization of the mitochondrial membrane,release of cytochrome c from mitochondria,activation of procaspase-9 and -3,and increase of DNA fragments.Moreover, the pan caspase inhibitor zVAD-FMK and the caspase-3 inhibitor zOEVD-FMK suppressed casticin-induced apoptosis.In addition,casticin induced XIAP and Bcl-XL down-regulation, Bax upregulation and Bid clearage.In H157 cell line,casticin increased expression of DRS at protein levels but not affect the expression of DR4.The prelreatmenl with DR5/Fc chimera protein effectively attenuated casticin-induced apoptosis in H157 cells.No correlation was found between cell sensitivity to casticin and that to p53 status,suggesting that casticin induce a p53- independent apoptosis.Conclusions:Our results demonstrate that casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DRS in human lung cancer cells. | Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 11 |
| 7 | Internal solitons in the northern South China Sea from insitu observations显示文摘In this paper, we demonstrate the characteris- tics of strong internal solitons at the southern edge of Dong- sha Islands in the northern South China Sea (SCS) during May―June 1998, using in situ time series data from the con- ductivity temperature depth (CTD), acoustic Doppler current profiler (ADCP) and thermistor chain. Our measurements indicated that the strongest internal solitons were larger than 90 m in wave amplitude, and propagated approximately westward in traveling direction, with the maximum current speed of about 2 m/s and the period of 10―20 min. The strongest internal solitons occurred noticeably during May 14―16, 1998, which is consistent with the occurrence period of the diurnal-dominated spring internal tides. | FANG Wendong SHI Ping LONG Xiaomin MAO Qingwen | 2005 | Chinese Science Bulletin2005，50，15： | 10 |
| 8 | Effect of Aidi injection plus chemotherapy on gastric carcinoma:a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To conduct a Meta-analysis of studies on the effect of Aidi injectioncombined with chemotherapy versus chemotherapy alone in the treatment of gastric cancer(GC).METHODS: Nine electronic databases and six gray literature databases were comprehensively searcheduntil April 20,2013. Two reviewers independently selected and assessed included trialsaccording to the inclusion and exclusion criteria. The risk of bias tool from the Cochrane Handbook version 5.1.0was used to assess trial quality. All calculations were performed using Review Manager 5.0.RESULTS: Thirty-two studies including 1927 participants met the inclusion criteria,most of which were low quality. Compared with chemotherapy alone,Aidi injection plusthe same chemotherapy significantly improved the effective rate [OR = 1.52,95% CI(1.24,1.86),P < 0.0001],clinical beneficial rate [OR = 1.77,95% CI(1.33,2.36),P < 0.0001],and quality of life [OR = 3.02,95% CI(2.39,3.82),P <0.000 01]. There was a significant improvement in nausea and vomiting incidence [OR = 0.34,95%CI(0.24,0.47),P < 0.000 01],diarrhea [OR = 0.47,95%CI(0.33,0.69),P < 0.000 01],leukopenia( 3,0.51),P = 0.05],hemⅢ-ogⅣ)[OR = 0.34,95%CI(0.2lobin decrease(thromⅢ-boⅣ) [OR = 0.42,95%CI(0.18-1.00),P = 0.05],cytopenia(4],and Ⅲ-damⅣ) [OR = 0.46,95%CI(0.22,0.96),P = 0.0age to liver function [OR = 0.36,95%CI(0.24,0.54),P < 0.000 01].CONCLUSION: Aidi injection combined with chemotherapy significantly improved the clinical effect of chemotherapy,reducing the incidence of adverse events. Use of the CONSORT statement for randomized controlled trials is recommended for stricter reporting. | Wang Jiancheng Ge Long Zhao Ye Li Jinlong Zhang Pan Mao Lei Yang Kehu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 9 |
| 9 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 10 | Molecular evolution of the rice miR395 gene family显示文摘MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that play important roles in plant and animal development. They are usually processed from larger precursors that can form stem-loop structures. Among 20 miRNA families that are conserved between Arabidopsis and rice, the rice miR395 gene family was unique because it was organized into compact clusters that could be transcribed as one single transcript. We show here that in fact this family had four clusters of total 24 genes. Three of these clusters were segmental duplications. They contained miR395 genes of both 120 bp and 66 bp long. However, only the latter was repeatedly duplicated. The fourth cluster contained miR395 genes of two different sizes that could be the consequences of intergenic recombination of genes from the first three clusters. On each cluster, both 1-duplication and 2-duplication histories were observed based on the sequence similarity between miR395 genes, some of which were nearly identical suggesting a recent origin. This was supported by a miR395 locus survey among several species of the genus Oryza, where two clusters were only found in species with an AA genome, the genome of the cultivated rice. A comparative study of the genomic organization of Medicago truncatula miR395 gene family showed significant expansion of intergenic spaces indicating that the originally clustered genes were drifting away from each other. The diverse genomic organizations of a conserved microRNA gene family in different plant genomes indicated that this important negative gene regulation system has undergone dramatic tune-ups in plant genomes. | Sreelatha GUDDETI De Chun ZHANG Ai Li LI Chuck H. LESEBERG Hui KANG Xiao Guang LI Wen Xue ZHAI Mitrick A. JOHNS Long MAO | 2005 | Cell Research2005，15，8： | 7 |
| 11 | Development and Analysis of an Electrically Actuated Lower Extremity Assistive Exoskeleton显示文摘一架电子上激活的更低的极限皮骨骼被开发,在哪个当有弹性的元素连接的另外的关节消极地被激活时,仅仅膝关节活跃地被激活。这份报纸描述批评设计标准并且介绍设计的进程和使活动系统的计算。一台灵活物理 Human-Robot-Interaction (pHRI ) 测量设备被设计并且适用检测人的运动,它包括纳入连接手铐的内部表面的二个力量传感器和二个气囊。联机适应 pHRI 最小化控制策略被建议并且实现了驱使机器的皮骨骼系统跟随人的手足的运动轨道。测量 pHRI 信息被变化加权的一般水准(VWA ) 方法熔化。pHRI 和控制转矩的吝啬的方形的价值(MSV ) 被利用评估皮骨骼的表演。改进舒适水平和还原剂精力消费,当控制法律被设计时,严肃赔偿被考虑。最后,实际实验在健康用户上被执行。试验性的结果证明建议系统能帮助人走,构画出的控制策略有效、有效。 | Yi Long Zhijiang Du Chaofeng Chen Weidong Wang Long He Xiwang Mao Guoqiang Xu Guangyu Zhao Xiaoqi Li Wei Dong | 2017 | Journal of Bionic Engineering2017，14，2： | 7 |
| 12 | Synthetic Hexaploid Wheat: Yesterday, Today, and Tomorrow显示文摘 | Aili Li Dengcai Liu Wuyun Yang Masahiro Kishii Long Mao | 2018 | Engineering2018，4，4： | 7 |
| 13 | Systematic identification of endogenous RNA polymeraseⅢpromoters for efficient RNA guidebased genome editing technologies in maize显示文摘Single-guide RNA(sg RNA) is one of the two core components of the CRISPR(clustered regularly interspaced short palindromic repeat)/Cas(CRISPR-associated) genome-editing technology. We established an in vitro Traffic Light Reporter(TLR) system, which is designated as the same colors as traffic lights such as green, red and yellow were produced in cells. The TLR can be readily used in maize mesophyll protoplast for a quick test of promoter activity. The TLR assay indicates the variation in transcription activities of the seven Pol III promoters, from 3.4%(U6-1) to over 21.0%(U6-6). The U6-2 promoter, which was constructed to drive sg RNA expression targeting the Zm Wx1 gene, yielded mutation efficiencies ranging from 48.5% to 97.1%. Based on the reported and unpublished data, the in vitro TLR assay results were confirmed to be a readily system and may be extended to other plant species amenable to efficient genome editing via CRISPR/Cas. Our efforts provide an efficient method of identifying native Pol III-recognized promoters for RNA guide-based genome-editing systems in maize. | Xiantao Qi Le Dong Changlin Liu Long Mao Fang Liu Xin Zhang Beijiu Cheng Chuanxiao Xie | 2018 | The Crop Journal2018，6，3： | 7 |
| 14 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 15 | Rare Earth Element and Trace Element Features of Gold-bearing Pyrite in the Jinshan Gold Deposit,Jiangxi Province显示文摘Jinshan 金沉积物位于东北江西,华南,它与有关可锻砍地区。它有超过 200 吨的金储备,与在黄铁矿的金发生中的 80% 个。金忍受的黄铁矿的 REE 平均象 171.664 ppm 一样更高,与相对更高的轻稀土元素元素(LREE;159.556 ppm ) 并且更低的 HREE (12.108 ppm ) 。LREE/HREE 比率是 12.612,(La/Yb ) N 是 11.765。这些显示那个黄铁矿富于 LREE。(La/Sm ) N 比率是 3.758 并且的(Gd/Yb ) N 是 1.695。这些是明显的 LREE 分别。有平均 Eu 的明显的 Eu 异例 0.664 珍视的稀土元素元素(REE ) 分发模式表演,和 1.044 的 Ce 异例。REE 特征类似于墙岩石(地区性的变形岩石) 的那些,但是与那些不同 Dexing granodiorite 斑岩和 Damaoshan 黑云母花岗石。这些特征显示在 Jinshan 金存款的形成矿石的材料源于墙岩石,并且形成矿石的液体源于变形的水。Co/Ni 比率(平均价值 0.38 ) 黄铁矿建议 Jinshan 金存款在 mediumlow 温度下面形成了。它从 Jinshan 金存款的形成矿石的液体与 Cl 从变形的水导出的黄铁矿的高地的力量元素, LREE, Hf/Sm, Nb/La,和 Th/La 的价值被推断 > F。 | MAO Guangzhou HUA Renmin GAO Jianfeng ZHAO Kuidong LONG Guangming LU Huijuan YAO Junming | 2010 | Acta Geologica Sinica(English Edition)2010，84，3： | 6 |
| 16 | A high-precision phase-derived range and velocity measurement method based on synthetic wideband pulse Doppler radar显示文摘Development of radar technology needs to address the two-dimensional high resolution of range and velocity simultaneously for high-speed targets. Taking advantage of the superior coherent performance of synthetic wideband pulse Doppler radar, this paper elaborates the principles of phase-derived range and velocity measurements. Moreover, this paper explores the key technologies of unwrapping phase ambiguity, and discusses the phase unwrapping strategy at a low signal-to-noise ratio(SNR). The proposed method can be applied to the conditions of low SNR and has comparatively strong practicality in engineering. Both the ejection ball and civil aircraft experiments have validated the correctness and feasibility of the proposed method. In particular,the experimental results reveal that the accuracy of phase-derived range and velocity measurement has reached a level of submillimeter or millimeter and centimeter/second or submillimeter/second, respectively. | Huayu FAN Lixiang REN Teng LONG Erke MAO | 2017 | Science China(Information Sciences)2017，60，8： | 6 |
| 17 | State-of-art of Geosynchronous SAR显示文摘Geosynchronous Earth Orbit Synthetic Aperture Radar(GEO SAR) runs in the height of 36000Km geosynchronous earth orbit,compared with traditional Low Earth Orbit(LEO) SAR(orbit height under 1000Km),GEO SAR has advantages of shorter repeat period,wider swath and so on.Firstly,the basic principle and state-of-art of GEO SAR in domestic and overseas are introduced.Secondly,coverage characteristic of GEO SAR is analyzed.Thirdly,the key problems of yaw steering and imaging on curved trajectory in GEO SAR are discussed in detail,and the corresponding primary solutions are presented in order to promote future research on GEO SAR. | MAO Er-ke LONG Teng ZENG Tao HU Cheng TIAN Ye | 2012 | 信号处理2012，28，4： | 6 |
| 18 | Making the Bread: Insights from Newly Synthesized AIIohexaploid Wheat显示文摘面包小麦(或普通小麦, Triticum aestivum )是 allohexaploid ( AABBDD , 2n = 6x = 42 )那由在栽培 tetraploid 小麦 T.turgidum 之间的杂交产生了( AABB , 2n = 4x = 28 )并且野 goatgrass Aegilops tauschii ( DD , 2n = 2x = 14 )。Polyploidization 为严密染色体修正提供了壁龛在细胞发生,基因,并且 epigenetic 层次,比它的祖先显示更宽广的传播。这评论在在有多倍体生长活力和改编的最新综合的 allohexaploid 小麦和可能的关联理解基因规定机制总结最近的进展。细胞发生的研究与初生的 allopolyploids 揭示整个染色体的 aneuploidy 的坚持的协会,与在普通小麦的基因稳定性相对照。整倍体的小麦的 Transcriptome 分析证明那小 RNA 是为 homoeo 等位基因表示规定经由的驱动力基因并且 epigenetic 机制。有到各自的祖先的表示水平优势的随后的 non-additively 表示的基因和那些可以在初生的 allohexaploid 小麦在生长活力和改编玩不同功能。allohexaploid 小麦的进一步基因的 diploidization 不是随机的。地区性的不均匀的基因分发,而非 subgenome 优势,在合成、自然的 allohexaploid 小麦被观察。分叉的染色体,特定的基因范畴的随后的选择,和 subgenome 特定的特点的组合效果为普通小麦的成功的建立是必要的。 | Ai-li Li Shuai-feng Geng Lian-quan Zhang Deng-cai Liu Long Mao | 2015 | Molecular Plant2015，8，6： | 6 |
| 19 | Nano-cerium-element-doped titanium dioxide induces apoptosis of Bel 7402 human hepatoma cells in the presence of visible light显示文摘AIM: To investigate the apoptotic effect of photoexcited titanium dioxide (TiO2) nanoparticles in the presence of visible light on human hepatoma cell line (Bel 7402) and to study the underlying mechanism. METHODS: Cerium-element-doped titanium dioxide nanoparticles were prepared by impregnation method. Bel 7402 human hepatoma cells were cultured in RPMI 1640 medium in a humidified incubator with 50 mL/L CO2 at 37℃. A 15 W fluorescent lamp with continuous wavelength light was used as light source in the photocatalytic test. Fluorescence morphology and agarose gel eletrophoresis pattern were performed to analyze apoptotic cells. RESULTS: The Ce (Ⅳ)-doped TiO2 nanoparticles displayed their superiority. The adsorption edge shifted to the 400-450 nm region. With visible light illuminated for 10 min, 10 μg/cm3 Ce (Ⅳ)-doped TiO2 induced micronuclei and significant apoptosis in 4 and 24 h, respectively. Hochest 33 258 staining of the fixed cells revealed typical apoptotic structures (apoptotic bodies), agarose gel electrophoresis showed typical DNA ladder pattern in treated cells but not in untreated ones. CONCLUSION: Ce (Ⅳ) doped TiO2 nanoparticles can induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light. | Long Wang Jian Mao Gao-Hua Zhang Ming-Jing Tu | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 20 | MIMO-SAR waveforms separation based on virtual polarization filter显示文摘The unwanted coupling exists inevitably among multiple orthogonal waveforms in a same frequency area for multiple-input and multiple-output synthetic aperture radar(MIMO-SAR). In this paper, a new polarized MIMO-SAR model is established with two transmitting antennas and multiple receiving antennas at first. Then, a virtual polarization filter(VPF) is proposed to separate superposed returns caused by multiple transmitted waveforms based on detection on the polarized parameters via particle swarm optimizer(PSO).Compared with the conventional matched filter to separate the orthogonal waveforms, it is shown that the coupling noises can be significantly suppressed by the proposed VPF-based method and the orthogonality is not necessary among different transmitting waveforms. Finally, experimental data experiments are also provided to demonstrate the effectiveness of the proposed method. | MENG CangZhen XU Jia XIA Xiang-Gen LIU Feng LONG Teng MAO ErKe YANG Jian PENG YingNing | 2015 | Science China(Information Sciences)2015，58，4： | 4 |
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