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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | A Confidence Limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R | 2003 | Proceedings of the Royal Society of London2003，459，： | 1 |
| 3 | Robotic-assisted sacrocol- popexy: technique and learning curve显示文摘 | Akl M N Long J B Giles D L | 2009 | Surgical Endoscopy2009，23，10： | 1 |
| 4 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis 显示文摘 | Huang N E Wu M L C Long S R | 2003 | Proceedings Royal of Society A2003，459，： | 1 |
| 5 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang N E Wu M L long S R | 2003 | Proc Royal Society of London Series2003，459，： | 1 |
| 6 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non - stationary time series analysis 显示文摘 | Huang N E Shen Z Long L S | 1998 | Proceedings Royal Society of London A1998，454，： | 1 |
| 7 | Metal alkynyl σ complexes:synthesis and materials显示文摘 | Long N L Williams C K | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 8 | Electrical conductivity of a single conducting polyaniline nanotube显示文摘 | Long Y Z Chen Z J Wang N L | 2003 | Appl Phys Lett2003，83，： | 1 |
| 9 | Object oriented unsteady vortex lattice method for flapping flight显示文摘 | Fritz T E Long L N | 2004 | Journal of Aircraft2004，41，6： | 1 |
| 10 | A confidence limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R Shen S S Qu W D Gloersen p and Fan K L | 2003 | Proceedings Royal Society of London2003，459，： | 1 |
| 11 | Existence and stability of solutions for generalized strong vector quasi-equilibrium problem显示文摘 | LONG X J HUANG N J TEO K L | 2008 | Mathematical and Computer Modeling2008，47，： | 1 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Long S R Wu M L C | 1998 | The royal society1998，454，： | 1 |
| 13 | A Confidence Limit for the Empirical Mode Decomposition and Hilbert Spectral Anaysis显示文摘 | HUANG N E WU M L LONG S R | 2003 | Proceedings of the Royal Society of London A2003，459，： | 1 |
| 14 | Distributed interference manage-ment in two-tier CDMA femtocell networks显示文摘 | DUY T N LONG B L EKRAM H | 2012 | IEEE Trans on Wire-less Commun2012，11，3： | 1 |
| 15 | Vitamin BI2 deficiency associated with concomitant metformin and proton pump in hibitor use显示文摘 | Long A N Atwell C L Yoo W | 2012 | Diabetes Care2012，35，12： | 1 |
| 16 | Existence and stability of solutions for generalized vector quasiequilibrium problem显示文摘 | Long X J Huang N J Teo K L | 2008 | Mathematical and Computer Modeling2008，47，： | 1 |
| 17 | A new efficient algorithm for computational aeroacoustics on parallel processors显示文摘 | OZYORUK Y LONG L N | 1996 | Journal of Computational Physics1996，，125： | 1 |
| 18 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Long S R Wu M L C | 1998 | Proceedings of the Royal Society1998，454，1971： | 1 |
| 19 | Engineering polyoxometalates with e- mergent properties 显示文摘 | Miras H N Yan J Long D L | 2012 | Chem Soc Rev2012，41，： | 1 |
| 20 | The development and implementation of an obstetric cell salvage service 显示文摘 | McDonnell N J Kennedy D Long L J | 2010 | Anaesth Intensive Care2010，38，4： | 1 |
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