| 2 | BACTERIAL ENDOCARDITIS:NATURAL HISTORY AND VALVULAR INVOLVEMENT显示文摘A total of 92 patients with baetenal endocarditis (BE) were treatedduring 1/1995-5/1998.48 patients were intravenous drug addicts (ID)(52.2%).The averase age of ID patients was 30.48+/-6.06 years.Themajority had been using drugs for more than 6 months (79.3%).Thevegetations were located mainly in the left heart (90.9%).All the casesof BE in ID patients occured in native valves.Differences were foundbetween non-ID (NID) and ID with regard to heart failure in ID (62.5%versus 16%) and to cerebral vascular accidents (25% versus 13%).Positive blood cultures were significantly more frequent in ID (95.5%)versus NID (44.4%).Streptoccocal D infections were predominant in ID(56.8%) and Streptococcal alpha infections in NID patients (44.4%),thedifference being statistically significant.The hospital mortality rate wassimilar in both groups,18.7% and 18.2% in ID and NID patientsrespectively.There were no surgical interventions in the ID group.Conclusions:In an area with high prevalence of rheumatic valvular diseasethe incidence of bacterial endocarditis in ID and NID showed difference inpresentations.Even there were no surgery in the ID group,the short termmortality was similar.There is a need to investigate the clinical benefit ofvalvular replacement end the survival of the ID and NID patients,in an areawhere resources are limited. | Nguyen Quoc Thai Do Doan Loi Nguyen Lan Viet Nguyen Ngoc Tuoc Pham Gia Khai | 1998 | 中国介入心脏病学杂志1998，6，4： | 0 |
| 3 | Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment显示文摘AIM: To use magnetic resonance-guided high intensity focused ultrasound(MRg-HIFU), magnetic resonance imaging(MRI) and histopathology for noninvasively ablating, quantifying and characterizing ablated renal tissue. METHODS: Six anesthetized/mechanically-ventilated pigs underwent single/double renal sonication(n = 24) using a 3T-MRg-HIFU(1.1 MHz frequency and 3000J-4400 J energies). T2-weighted fast spin echo(T2-W), perfusion saturation recovery gradient echo and contrast enhanced(CE) T1-weighted(T1-W) sequences were used for treatment planning, temperature monitoring, lesion visualization, characterization and quantification, respectively. Histopathology was conducted in excised kidneys to quantify and characterize cellular and vascular changes. Paired Student's t-test was used and a P-value < 0.05 was considered statistically significant.RESULTS: Ablated renal parenchyma could not be differentiated from normal parenchyma on T2-W or nonCE T1-W sequences. Ablated renal lesions were visible as hypoenhanced regions on perfusion and CE T1-W MRI sequences, suggesting perfusion deficits and necrosis. Volumes of ablated parenchyma on CE T1-W images invivo(0.12-0.36 cm3 for single sonication 3000 J, 0.50-0.84 cm3, for double 3000 J, 0.75-0.78 cm3 for single 4400 J and 0.12-2.65 cm3 for double 4400J) and at postmortem(0.23-0.52 cm3, 0.25-0.82 cm3, 0.45-0.68 cm3 and 0.29-1.80 cm3, respectively) were comparable. The ablated volumes on 3000 J and 4400 J double sonication were significantly larger than single(P < 0.01), thus, the volume and depth of ablated tissue depends on the applied energy and number of sonication. Macroscopic and microscopic examinations confirmed the locations and presence of coagulation necrosis, vascular damage and interstitial hemorrhage, respectively.CONCLUSION: Contrast enhanced MRI provides assessment of MRg-HIFU renal ablation. Histopathology demonstrated coagulation necrosis, vascular damage and confirmed the volume of damage seen on MRI. | Maythem Saeed Roland Krug Loi Do Steven W Hetts Mark W Wilson | 2016 | World Journal of Radiology2016，8，3： | 0 |
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