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| 1 | 中美医学生课程设置的对比研究和启示——以北京大学和匹兹堡大学为例显示文摘目的探讨目前中国和美国医学生培养过程中课程设置的差异,以及对我国医学生教育的启示。方法选取北京大学2010级8年制学生的课表和匹兹堡大学同年级医学生的课表进行比较。比较课程数量、课程分布、创新能力培养情况、医患沟通课程。采用SPSS 20.0对相关数据进行t检验和卡方检验。结果两所医学院校的课程总数接近,北京大学每学年学习周数为(41.6±8.7),匹兹堡大学每学年学习周数为(39.6±8.5),经过配对t检验,差异无统计学意义(t=1.414,P=0.200)。课程分布均为由综合课程向医学课程,基础课程向临床课程过渡的方式。专业课程的设置类似。创新型能力培养及医患沟通教育均体现在两所高校的课程中,但匹兹堡大学的相应培养课程开设较早,形式灵活。其中,医患沟通课时,北京大学累计47学时,形式为大课;匹兹堡大学累计140课时,包括大课讲授、与标准患者的交流和与真实患者的交流;经卡方检验,差异具有统计学意义(χ^2=67.45,P=0.000)。结论经过20余年的医学教育改革,我国部分院校医学生课程设置已经基本达到发达国家水平,专业课程设置与发达国家医学院的设置相似,但仍然需要加强学生创新能力培养和医学人文教育。 | 洪颖 丁瞳 李学民 王薇 Priyal Shah Nils A. Loewen | 2019 | 中华医学教育探索杂志2019，18，4： | 7 |
| 2 | Two-year outcomes of ab interno trabeculectomy with the Trabectome for Chinese primary open angle glaucoma: a retrospective multicenter study显示文摘AIM: To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open angle glaucoma(POAG) patients.METHODS: This was a multicenter, retrospective, observational study and included POAG patients with or without visually-significant cataracts. The Chinese patients were enrolled from three glaucoma centers and a group of comparable Japanese POAG patients was analyzed from our international Trabectome database. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome was intraocular pressure(IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2 y. Success was defined as: 1) IOP≤21 mm Hg and at least 20% IOP reduction from baseline after 3 mo at any two consecutive visits; 2) no additional glaucoma surgery required.RESULTS: A total of 42 Chinese POAG patients from three glaucoma centers were enrolled. Twelve patients underwent Trabectome surgery combined with phacoemulsification and intraocular lens implantation while the remainder underwent Trabectome surgery alone. Thirteen patients had a history of failed glaucoma surgery and were considered as complicated cases. In China data, the mean preoperative IOP was 21.4±1.23 mm Hg. The Trabectome lowered IOP to 17.9±1.8 mm Hg at 2 y(P=0.05). The number of glaucoma medications also decreased significantly from a baseline of 2.0±0.9 to 1.1±0.8 at 2 y post-surgery(P=0.04). The overall 2-year success rate was 78%, with patients undergoing combined surgery having a higher success rate compared with those undergoing Trabectome surgery alone(100% vs 76%). In Japan data, the mean preoperative IOP was 20.8±7.7 mm Hg. The Trabectome lowered IOP to 12.20±2.0 mm Hg at 2 y. The number of glaucoma medications also decreased significantly from a baseline of 2.1±0.9 to 3.4±0.6 at 2 y post-surgery. In all patients, no major complications were seen.CONCLUSION: Surgery with the Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the long-term. | Ya-Long Dang Xiao Wang Wan-Wei Dai Ping Huang Nils A Loewen Chun Zhang 无 | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 5 |
| 3 | Efficacy and safety of micropulse laser trabeculoplasty for primary open angle glaucoma显示文摘AIM: To evaluate the efficiency and safety of micropulse laser trabeculoplasty(MLT) for primary open angle glaucoma(POAG) patients. METHODS: Retrospective study. POAG patients undergoing MLT in Peking University Third Hospital from June 2016 to November 2017. Seventy-two eyes of 72 POAG patients were enrolled. Only one eye of each patient was treated by MLT. The intraocular pressure(IOP) before MLT and at 1 d, 1, 4, 12 and 24 wk and glaucoma medication before and after treatment were compared.RESULTS: The IOP was 20.6±5.9 mm Hg before MLT and 20.8±6.8 mm Hg at 2 h after MTL. The IOP at 1 d, 1, 4, 12 and 24 wk was 17.9±4.4, 18.0±4.3, 17.5±3.4, 17.0±2.7, and 16.5±2.9 mm Hg, respectively. The IOP before and after MLT demonstrated a statistically significant difference by ANOVA analyses(F=5.797, P<0.001). Least significant difference t-tests showed there was no statistically significant difference between pre-MLT IOP within 2 h after MLT(P=0.207). The statistically significant difference was confirmed between the pre-MLT IOP at 1 d, 1, 4, 12 and 24 wk after MLT(P=0.006, 0.009, 0.001, <0.001, <0.001, respectively). The number of glaucoma medications before MLT was 1.7±1.4 and 1.5±1.4 24 wk after MLT with a significantly statistical difference(t=2.219, P=0.031)CONCLUSION: MLT is effective and safe for POAG patients. No patient experienced IOP spikes after MLT. The IOP 6 mo after treatment decreased significantly with less glaucoma medication. | Ying Hong Si-Jia Song Bo Liu Kiana Hassanpour Chun Zhang Nils Loewen | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 4 | Doing focus-on-form显示文摘 | Rod Ellis Helen Basturkmen Shawn Loewen | 2002 | System2002，，4： | 2 |
| 5 | Catalase HPII from Escherichia coli Exhibits Enhanced Resistance to Denaturation显示文摘 | Switala J O'Neil J O Loewen P C | 1999 | Biochemistry1999，38，13： | 1 |
| 6 | Diversity of structures andproperties among catalases 显示文摘 | Chelikani P Fita I Loewen P | 2004 | Cellular and Molecular Life Sciences CMLS2004，61，2： | 1 |
| 7 | In vitro and in vivo comparison of two suprachoroidal shunts 显示文摘 | Oatts JT Zhang Z Tseng H Shields MB Sinard JH Loewen NA | 2013 | Invest Ophthalrrwl Vis Sci2013，54，8： | 1 |
| 8 | Doing Focus-on-form 显示文摘 | Ellis R Basturkmen H Loewen S | 2002 | System2002，，30： | 1 |
| 9 | Losarten as an alternative to ACE inhibitors in patients with renal dysfunction 显示文摘 | Esmail ZN Loewen PS | 1998 | Annals of Pharmacotherapy1998，32，10： | 1 |
| 10 | Colloidal soft matter under external control显示文摘 | Loewen H | 2001 | J Physics: Condensed Matter2001，13，： | 1 |
| 11 | Genetic map- ping of KatG,a locus that affects synthesis of the bifunc tional catalase peroxidase hydroperoxidase I in Esche richia coli 显示文摘 | Loewen P C Triggs B L George C S | 1985 | Journal of Bacteriology1985，162，2： | 1 |
| 12 | Teachers' Stated Beliefs about Incidental Focus on Form and their Classroom Practice 显示文摘 | Basturkmen H Loewen S Ellis R | 2004 | Applied Linguistics2004，25，2： | 1 |
| 13 | Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment 显示文摘 | Loewen G Natarajan N Tan D | 2007 | Thorax2007，62，4： | 1 |
| 14 | Comparison of methods to determine the microbiological contamination of sur- faces of beef carcasses by hydrophobic grid membrane filters, standard pour plates or flow cytometry显示文摘 | Jerichol K W F Kozub G C Loewen K G | 1996 | Food Microbiology1996，13，： | 1 |
| 15 | Invasive fungal disease in adult undergoing remlssion-induction therapy for acute myeloid leukemia: the pathogenic role of the antileukemic regimen 显示文摘 | Bow EJ Loewen R Cheang MS | 1995 | Clin Infect Dis1995，21，2： | 1 |
| 16 | A juvenile allosaur with preserved integument from the basal Morrison Formation of central Wyoming显示文摘 | Pinegar R T Loewen M A Cloward K C | 2003 | Journal of Vertebrate Paleontology2003，23，： | 1 |
| 17 | Predictors of stroke outcome using objec- tive measurement scales显示文摘 | Loewen SC Anderson BA | 1990 | Stroke1990，21，1： | 1 |
| 18 | The broadly selective human Na+/nucleoside cotransport- er (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics 显示文摘 | Smith K M Slugoski M D Loewen S K | 2005 | J Biol Chem2005，280，25： | 1 |
| 19 | Response of genioglossus muscle to increasing chemical drive in sleeping obstructive apnea patients显示文摘 | Loewen AH Ostrowski M Laprairie J | 2011 | Sleep2011，34，8： | 1 |
| 20 | Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment显示文摘 | Loewen G Natarajan N Tan D | 2007 | Thorax2007，62，4： | 1 |
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