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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Plasma insulin,glu- cose,IGF- Ⅰ ,IGF- Ⅱ,and IGFBP-3 and risk of recurrent colorectal adenomas 显示文摘 | Kang M Peery AF Locklear C | 2013 | J Gastroenterol Hepatol Res2013，2，4： | 1 |
| 3 | Partial compliance and risk of rehospitalization among California Medicaid patients with schizophrenia显示文摘 | WEIDEN PJ KOZMA C GROGG A LOCKLEAR J | 2004 | Psychiatric Services2004，55，8： | 1 |
| 4 | Cost efffectiveness of long-acting risperidone injection versus alternative antipsychotic agents in patients with schizophrenia in USA显示文摘 | EDWARDS NC LOCKLEAR JC Rupnow MF | 2005 | Pharmacoeconomics2005，23，1： | 1 |
| 5 | Using the BTE Primus to measure grip and wrist flexion strength in physi- cally active wheelchair users: an exploratory study显示文摘 | Shechtman O MacKinnon L Locklear C | 2001 | Am J Occup Ther2001，55，4： | 1 |
| 6 | Plasma insulin,glucose,IGF-I,IGF-II,and IGFBP-3and risk of recurrent colorectal adenomas显示文摘 | Kang M Peery A F Locklear C | 2013 | J Gastroenterol Hepatol Res2013，2，4： | 1 |
| 7 | PMH71 The Impact of Once-Daily Extended-Release Quetiapine Fumarate(Quetiapine XR)on Length and Costs of Hospitalisation of Patients with Schizophrenia or Bipolar Disorder显示文摘 | Locklear J C Wahlqvist P Gustafsson U | 2011 | Value in Health2011，14，7： | 1 |
| 8 | PMH72 the impact of once-daily extended-release quetiapine fumarate(Quetiapine XR)on length of hospitalisation of patients with acute bipolar mania显示文摘 | Bonafede M Locklear JC Wahlqvist P | 2011 | Value in Health2011，14，7： | 1 |
| 9 | Assessment of the effects of sex and sex hormones on spatial cognition in adult rats using the Barnes maze显示文摘 | Locklear MN Kritzer MF | 2014 | Horm Behav2014，66，2： | 1 |
| 10 | Assessment of compliance with antipsychotic treatment and resource utilization in a Medicaid population显示文摘 | Eaddy M Grogg A Locklear J | | 0，，2： | 1 |
| 11 | Static tests of jet fuel thermal and oxidative stability显示文摘 | Hendghan Shawn P Locklear Stacy L Geiger David L | 1993 | Journal of Propulsion and Power1993，9，1： | 1 |
| 12 | Effects of the dietary phytoestrogens daidzein and genistein on the incidence of vulvar carcinomas in 129/J mice显示文摘 | Julis E Thigpen Jacqueline Locklear Joseph K | 2001 | Cancer detection and prevention2001，25，： | 1 |
| 13 | Effects of the dietary phytoe-strogens daidzein and genistein on the incidence of vulvar carcinomas in 129/J mice显示文摘 | Thigpen J E Locklear J Joseph K | 2001 | Cancer Detection and Prevention2001，25，： | 1 |
| 14 | A single step purification for autolytic zinc, proteinases显示文摘 | Wilfong EM Locklear U Toone EJ | 2010 | Bioorg Med Chem Lett2010，20，1： | 1 |
| 15 | Ionic constituents and osmolality of gastric and smallintestinal fluids after eating 显示文摘 | Fordtran JS Locklear TW | 1966 | Am J Dig Dis1966，11，7： | 1 |
| 16 | Arbitration in Olympic Disputes: Should Arbitrators Review the Field of Play Decisions of Officials 显示文摘 | LOCKLEAR R J | 2003 | Texas Review of Entertainment&Sports Law2003，4，1： | 1 |
| 17 | Ionic constituents and osmolality of gastric and small-intestinal fluids after eating显示文摘 | John S. Fordtran Travis Ward Locklear | 1966 | The American Journal of Digestive Diseases1966，，7： | 1 |
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