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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | 用喷雾法提高哈次木霉1295-22对草坪草病害的生防效果显示文摘哈次木霉(Trichoderma harzianum)1295-22菌株是一种对多种真菌病害具有较好防治效果的生物制剂。研究报道了施用1295-22的颗粒剂和雾剂对匍匐剪股颖的腐霉根腐、褐斑和币斑病的防治效果。研究表明在温室或田间,喷施1295-22的分生孢子悬浮液(SA),都显著减轻了匍匐剪股颖草坪的这3种病害。若在孢子水悬液中添加0.1%的Triton X-100的防治效果更好。若每周都喷洒SA,其防治效果相当于常规杀菌剂。撒施颗粒剂(GA)也能显著减轻根腐病、币斑病和褐斑病的叶部症状,草坪质量也有所提高。用1295-22的SA或GA处理过的剪股颖根区的木霉菌(Trichoderma spp.)群体比未处理的提高了10~100倍,但是仅在喷施SA之后,1295-22才以高水平存在。总之,1295-22在根围和叶围都有较强的竞争力。在使用颗粒剂之后再喷施分生孢子悬浮液可减轻根部和叶部病害。 | Lo C T Nelson E B 朱廷恒 | 1999 | 国外畜牧学(草原与牧草)1999，，2： | 4 |
| 3 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 4 | Composting salmon farm mortalities with passive areration显示文摘 | Liao P H Vizcarra A T Chen A Lo K V | 1996 | Compost Science and Utilization1996，2，4： | 2 |
| 5 | Modulation of plasminogen activator inbibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition显示文摘 | OIKAWA T FREEMAN M LO W | 1997 | Kidney Int1997，51，1： | 2 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 8 | Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy显示文摘 | Olson L G Lo Y S Beebe T P | 2001 | Analytical Chemistry2001，73，： | 1 |
| 9 | Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phos- phatidylinositol 3-kinase-dependent pathway 显示文摘 | Gurlo T Haataja LO Hsueh WA | 2005 | J Clin Endocrinol Metab2005，90，12： | 1 |
| 10 | Rapid clearance of fetal DNA from maternal plasma显示文摘 | Lo Y M Zhang J Leung T N | 1999 | Am J Hum Genet1999，64，： | 1 |
| 11 | Novel baculovirus DNA elements strongly stimulate activities of exogenous and endogenous promoters 显示文摘 | LO H R CHOU C C WU T Y | 2002 | The Journal of Biological Chemistry2002，277，7： | 1 |
| 12 | ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonistinduced μ-opioid receptor endocytosis 显示文摘 | Koch T Brandenburg LO Schulz S | 2003 | J Biol Chem2003，278，11： | 1 |
| 13 | Remote Sensing of Complex Permittivity by Multipole Resonances in RCS显示文摘 | DAVID J BURR YUEN T LO | 1973 | IEEE Transactions on Antennas and Propagation1973，21，4： | 1 |
| 14 | Real-time garbage collection for flash-memory storage systems of realtime embedded systems 显示文摘 | Chang L P Kuo T W Lo S W | 2004 | ACM Transactions on Embedded Computing Systems2004，3，4： | 1 |
| 15 | Advances in stroke neuroprotection: hyperoxia and beyond 显示文摘 | SINGHAL AB LO EH DALKARA T | 2005 | Neuroimag Clin N Am2005，15，3： | 1 |
| 16 | Mechanisms of hyperbaric oxygen and neuroprotection in stroke 显示文摘 | Zhang JH Lo T Mychaskiw G | 2005 | Pathophysiology2005，12，1： | 1 |
| 17 | Time-to-voltage converter for on- chip jitter measurement 显示文摘 | XIA T LO J C | 2003 | IEEE Trans Instru Measur2003，52，6： | 1 |
| 18 | Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange(Citrus sinensis) peel显示文摘 | Li S Lo C Y Ho C T | 2006 | Journal of Agriculture Food Chemistry2006，54，： | 1 |
| 19 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 20 | Removal of refractory compounds from stabilized landfill leachate using an integrated 1-1202 oxidation and granular activated carbon (GAC) adsorption treatment显示文摘 | Kumiawan T A Lo W | 2009 | Water Research2009，43，16： | 1 |
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