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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Extracellular proteolysis in brain injury and inflammation:role for plasminogen activators and matrix metalloproteinases显示文摘 | Lo EH Wang X Cuzner ML | 2002 | J Neurosci Res2002，69，： | 1 |
| 3 | Expression of theapoptosis inhibitor survivin in aggressive squamous cellcarcinoma显示文摘 | Lo ML Staibano S Pannone G | 2001 | Exp Mol Pathol2001，70，3： | 1 |
| 4 | The artery of the atrioventricular node: an anatomic study Based on38 injection-dissections显示文摘 | Sow ML NdoyeJM Lo EA | 1996 | SurgRadi- olArmt1996，18，3： | 1 |
| 5 | Oral lichen planus and HCV infection : a clinical evaluation of 263 cases 显示文摘 | Mignogna MD Lo ML Favia G | 1998 | Int J Dermatol1998，37，8： | 1 |
| 6 | Oral lichen planus: different clinical features in HCV-positive and HCV-negative patients 显示文摘 | Mignogna MD Lo ML Lo RL | 2000 | Int J Dermatol2000，39，2： | 1 |
| 7 | Postoperative sore throat and katamine gargle显示文摘 | Chan L Lee ML Lo YL | 2010 | BrJ Anaesth2010，105，1： | 1 |
| 8 | Gap junction communication and the modulation of cardiac neural crest cells 显示文摘 | Lo CW Waldo KL Kirby ML | 1999 | Trends Cardiovasc Med1999，9，34： | 1 |
| 9 | Expression of neuronal nitric oxide synthase during embryonic development of the rat cerebral cortex 显示文摘 | Santacana M Uttenthal LO Bentura ML | 1998 | Brain Res Dev Brain Res1998，111，2： | 1 |
| 10 | Apolipoprotein D expression in retinoblastoma显示文摘 | Alvarez ML Barbon JJ Gonzalex LO | 2003 | Ophthalmic Res2003，35，2： | 1 |
| 11 | Apolipoprotein D expression in endometrial carcinomas显示文摘 | Rojo JV Gonzalez LO Lamelas ML | 2001 | Acta Obstet Gynecol Scand2001，80，2： | 1 |
| 12 | Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma显示文摘 | Lo ML Staibano S Pannone G | | 0，，： | 1 |
| 13 | Extracellular proteolysis inbrain in jury and inflammation: role for plasminogen activators and matrix metalloproteinases显示文摘 | Lo EH Wang X Cuzner ML | 2002 | J Neurosci Res2002，69，1： | 1 |
| 14 | GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children 显示文摘 | Testi AM Biondi A Lo Coco F Moleti ML Giona F Vignetti M | 2005 | Blood2005，106，2： | 1 |
| 15 | Preserved oxygenation despite reduced blood flow in poststenotic kidneys in human atherosclerotic renal artery stenosis显示文摘 | Gloviczki ML Glockner JF Lerman LO | 2010 | Hypertension2010，55，4： | 1 |
| 16 | Leptin显示文摘 | Lo P Wong ML Licinio J | 1998 | Int J Biochem Cell Biol1998，30，： | 1 |
| 17 | GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children显示文摘 | Testi AM Biondi A Lo Coco F Moleti ML Giona F Vignetti M | 2005 | Blood2005，106，2： | 1 |
| 18 | Brain necrosis after radiotherapy for primary intracerebral tumor显示文摘 | Hohwieler ML Lo TCM Silverman ML | 1992 | Neurosurgery1992，18，： | 1 |
| 19 | An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors显示文摘 | Choong ML Tan LK Lo SL | 2001 | FEBS Lett2001，，23： | 1 |
| 20 | Phototherapy fortreating pressure ulcers显示文摘 | Chen C Hou WH Chan ES Yeh ML Lo HL | 2014 | Cochrane Database Syst Rev2014，7，00： | 1 |
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