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| 1 | Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer显示文摘AIM: To compare the clinicopathological features of patients with non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer.METHODS: All the patients with rectosigmoid carcinoma who underwent laparoscopic radical surgical resection in the Shanghai Minimally Invasive Surgical Center at Ruijin Hospital affiliated to Shanghai JiaoTong University between October 2009 and October2013 were included in this study. Twenty-six cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected. Symptoms,endoscopic findings and clinicopathological characteristics were evaluated retrospectively.RESULTS: There were no significant differences between patients with and without schistosomiasis in gender, age, CEA, CA19-9, preoperative biopsy findings or postoperative pathology. Patients with rectosigmoid schistosomiasis had a significantly higher CA-125 level and a larger proportion of these patients were at an early tumor stage(P = 0.003). Various morphological characteristics of schistosomiasis combined with rectosigmoid cancer could be found by colonoscopic examination: 46% were fungating mass polyps, 23%were congestive and ulcerative polyps, 23% were cauliflower-like masses, 8% were annular masses.Only 27% of the patients were diagnosed with rectal carcinoma preoperatively after the biopsy. Computed tomography(CT) scans showed thickened intestinal walls combined with linear and tram-track calcifications in 26 patients.CONCLUSION: Rectosigmoid carcinoma combined with schistosomiasis is associated with higher CA-125 values and early tumor stages. CA-125 and CT scans have a reasonable sensitivity for the accurate diagnosis. | Hao Feng Ai-Guo Lu Xue-Wei Zhao Ding-Pei Han Jing-Kun Zhao Lei Shi Tobias S Schiergens Serene ML Lee Wen-Peng Zhang Wolfgang E Thasler | 2015 | World Journal of Gastroenterology2015，21，23： | 6 |
| 2 | Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells显示文摘AIM:To investigate the role of reactive oxygen species(ROS) in ethanol-mediated cell death of polarized hepatic(WIF-B) cells.METHODS:In this work,WIF-B cultures were treated with pyrazole(inducer of cytochrome P4502E1,CYP2E1) and/or L-buthionine sulfoximine(BSO),a known inhibitor of hepatic glutathione(GSH),followed by evaluation of ROS production,antioxidant levels,and measures of cell injury(apoptosis and necrosis).RESULTS:The results revealed that ethanol treatment alone caused a significant two-fold increase in the activation of caspase-3 as well as a similar doubling in ROS.When the activity of the CYP2E1 was increased by pyrazole pretreatment,an additional two-fold elevation in ROS was detected.However,the CYP2E1-related ROS elevation was not accompanied with a correlative increase in apoptotic cell injury,but rather was found to be associated with an increase in necrotic cell death.Interestingly,when the thiol status of the cells was manipulated using BSO,the ethanol-induced activation of caspase-3 was abrogated.Additionally,ethanol-treated cells displayed enhanced susceptibility to Fas-mediated apoptosis that was blocked by GSH depletion as a result of diminished caspase-8 activity.CONCLUSION:Apoptotic cell death induced as a consequence of ethanol metabolism is not completely dependent upon ROS status but is dependent on sustained GSH levels. | Benita L McVicker Pamela L Tuma Kusum K Kharbanda Serene ML Lee Dean J Tuma | 2009 | World Journal of Gastroenterology2009，15，21： | 5 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Impact of asialoglycoprotein receptor deficiency on the development of liver injury显示文摘The asialoglycoprotein (ASGP) receptor is a wellcharacterized hepatic receptor that is recycled via the common cellular process of receptor-mediated endocytosis (RME). The RME process plays an integral part in the proper traff icking and routing of receptors and ligands in the healthy cell. Thus, the missorting or altered transport of proteins during RME is thought to play a role in several diseases associated with hepatocyte and liver dysfunction. Previously, we examined in detail alterations that occur in hepatocellular RME and associated receptor functions as a result of one particular liver injury, alcoholic liver disease (ALD). The studies revealed profound ethanolmediated impairments to the ASGP receptor and the RME process, indicating the importance of this receptor and the maintenance of proper endocytic events in normal tissue. To further clarify these observations, studies were performed utilizing knockout mice (lacking a functional ASGP receptor) to which were administered several liver toxicants. In addition to alcohol, we examined the effects following administration of antiFas (CD95) antibody, carbon tetrachloride (CCl4) and lipopolysaccharide (LPS)/galactosamine. The results of these studies demonstrated that the knockout mice sustained enhanced liver injury in response to all of the treatments, as shown by increased indices of liver damage, such as enhancement of serum enzyme levels, histopathological scores, as well as hepatocellular death. Overall, the work completed to date suggests a possible link between hepatic receptors and liver injury. In particular, adequate function and content of the ASGP receptor may provide protection against various toxinmediated liver diseases. | Serene ML Lee Carol A Casey Benita L McVicker | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 5 | Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism 显示文摘 | Wolfe MW Lee RT Feldstein ML | 1994 | Am Heart J1994，127，5： | 1 |
| 6 | Thrombospondin modules and angiogenesis显示文摘 | Iruela-Arispe ML Luque A Lee N | 2004 | Int J Biochem Cell Biol2004，36，6： | 1 |
| 7 | Vascular endothelial growth factor gene polymorphism and pro- tein expression in the pathogenesis of pterygium显示文摘 | Peng ML Tsai YY Tung JN Chiang CC Huang YC Lee H | 2014 | Br J Oph- thalmol2014，98，4： | 1 |
| 8 | Percutaneous versus surgical treatment for patients with hypertrophic obstructive cardiomyopathy and enlarged anterior mitral valve leaflets显示文摘 | Van der Lee C ten Cate FJ Geleijnse ML | 2005 | Circulation2005，112，4： | 1 |
| 9 | Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor 显示文摘 | Lee JE Fusco ML Hessell AJ et O1 | 2008 | Nature2008，454，7201： | 1 |
| 10 | Surgical outcome in patients with epilepsy with occult vascular malformations treated with lesionectomy 显示文摘 | Kraemer DL Griebel ML Lee N | 1998 | Epilepsia1998，39，6： | 1 |
| 11 | High-resolution sonography versus EMG in the diagnosis of carpal tunnel syndrome显示文摘 | Visser LH Smidt MH Lee ML | 2008 | Neurol Neurosurg Psychiatry2008，79，1： | 1 |
| 12 | Type I interferons protect mice against enterovirus 71 infection 显示文摘 | Liu ML Lee YP Wang YF Lei HY Liu CC Wang SM Su IJ Wang JR Yeh TM Chen SH Yu CK | 2005 | J Gen Virol2005，86，12： | 1 |
| 13 | Pathogenesis of hair infection and black dots in tinea capitis caused by Trichophyton violaceum:a histopathological study显示文摘 | Lee JY Hsu ML | 1992 | J Cutan Pathol1992，19，1： | 1 |
| 14 | Paeoniae radix, a Chinese herbal extract, inbibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway 显示文摘 | Lee M Li ML Tse YC | 2002 | Life Sci2002，71，19： | 1 |
| 15 | Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice显示文摘 | Lee CR Imig JD Edin ML | 2010 | FASEB J2010，24，10： | 1 |
| 16 | Vasopressin:a new target for the treatment of heart failure 显示文摘 | Lee CR Watkins ML Ratterson JH | 2003 | Am heart J2003，146，： | 1 |
| 17 | Interferon alfa2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C显示文摘 | McHutchison JG Gordon SC Schiff ER Shiffrnan ML Lee WM Rustgi VK Goodman ZD Ling MH Cort S Albrecht JK | | 0，，： | 1 |
| 18 | Alpha-synuclein in Lewy bodies显示文摘 | Spillantini MG Schmidt ML Lee VM | 1997 | Nature1997，388，： | 1 |
| 19 | Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2and TLR-4activation显示文摘 | Kim KW Cho ML Lee SH | 2007 | Immunol Lett2007，110，1： | 1 |
| 20 | Micropropagation of Cucurbita foetidissima and Asclepias syriaca throught shoot tip culture of seeding 显示文摘 | Lian ML Lee S Paek KY | 2000 | Korea J Plant Tissue Cuhure2000，27，： | 1 |
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