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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | 立体定向融合影像技术在治疗脑动静脉畸形引发癫痫的定位作用显示文摘目的探讨立体定向结合脑血管造影与MRI影像融合在治疗脑动静脉畸形引发癫痫时对脑功能区、脑内病变和致痫灶空间范围的定位作用。方法对17例患者采用Talairach立体定向系统,绘制脑皮质表面血管图,并与三维MRI成像进行融合,标注脑功能区并设计术前深部电极放置部位和手术方案。结果17例患者获得了清晰的立体脑血管造影与MRI图像,涉及手术部位包括额叶8例、顶叶6例、颞叶2例和枕叶1例。手术完整切除动静脉畸形。术后随访1年,8例未见癫痫发作。结论该技术可以保证术前准确定位病灶,有利于术中判断脑沟回和功能区,避免损伤皮质功能区和血管。 | 赵国光 F Cardinale M Cossu G Lo Russo | 2005 | 中国脑血管病杂志2005，2，7： | 3 |
| 3 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 4 | Biomechanical correlations of lesions assocjated with traumatic diseases of the anterjor cruciate ligament:Analysis with MR显示文摘 | Demaria M Barbiera F Lo Casto A | 1996 | Radiol Med Torino1996，91，6： | 1 |
| 5 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 6 | Anthro- pogenic carbon distributions in the Atlantic Ocean: Data-based estimates from the Arctic to the Antarctic 显示文摘 | V~izquez-Rodriguez M Touratier F Lo Monaco C | 2009 | Biogeosciences2009，6，3： | 1 |
| 7 | Kinetics g plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma 显示文摘 | Lo Y M Leung S F Chart L Y | 2000 | Cancer Res2000，60，： | 1 |
| 8 | Molecular prognostication of nasopharygeal carcinoma by quantitative analysis Of circulating Epstein-Barr virus DNA 显示文摘 | LO Y M LEUNG S F CHAN L Y | 2000 | CancerRes2000，60，： | 1 |
| 9 | The investigation of electrochemical properties and ionic motion of functionalized copolymer electrolytes based on polysiloxane 显示文摘 | WANG F M HU C C LO S C | 2009 | Solid State Ionics2009，180，45： | 1 |
| 10 | New modalities of regional and global left ventricular function analysis:state of the art显示文摘 | Fedele F J rambaio lo P M agn G | | 0，，01： | 1 |
| 11 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 12 | Transcriptional analysis of the ribbonnudeotide reductase genes of shrimp white spot syndrome virus显示文摘 | TSAI M F LO C F VAN HULTEN M C | 2000 | Virology2000，277，1： | 1 |
| 13 | ATRA and arsenic trioxide (ATO) versus ATRA and idarubicin (AI- DA) for newly diagnosed, non high-risk acute promyelo- cytie leukemia (APL) : results of the phase III, prospec- tive, randomized, intergroup APL0406 study by the Ital- ian-German cooperative groups GIMEMA-SAL-AMLSG 显示文摘 | Lo Coco F Avvisati G Orlando S M | 2012 | Blood2012，120，1： | 1 |
| 14 | Pulsed laser deposition and electrochemical characterization of LiFePO4-Ag composite thin films显示文摘 | Lu Z G Cheng H Lo M F | | 0，，18： | 1 |
| 15 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model 显示文摘 | Henderson WR Jr Tang LO Chu SJ Tsao SM Chiang GK Jones F Jonas M Pae C Wang H Chi EY | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 16 | Isolated hydatid diseases of the spleen: CT findings in patients and differential diagnosis显示文摘 | Lo Gasto A Galia M Barbiera F | 2002 | Radiol Med(Torino)2002，104，3： | 1 |
| 17 | Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases显示文摘 | YU X M LO C Y CHAN W F | | 0，，22： | 1 |
| 18 | The effect of humidity and state of water surfaces on deposition of aerosol particles onto a water surface显示文摘 | LO A K F ZHANG L M SIEVERING H | 1999 | Atmospheric Environment1999，33，28： | 1 |
| 19 | Definition of relapse risk and role of nonanthracychne drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，4： | 1 |
| 20 | The effects of tertiary wastewater treatment on the prevalence of antimicrobial re- sistant bacteria显示文摘 | Luca G Danilo M A Lo F W | 2002 | Water Research2002，36，： | 1 |
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