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| 1 | Mitochondrial dysfunction,oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate显示文摘The treatment of microglial BV-2 cells with sodium arsenate(As(V):0.1-400 μmol/L — 48 hr)induces a dose-dependent response.The neurotoxic effects of high concentrations of As(V)(100,200 and 400 μmol/L) are characterized by increased levels of mitochondrial complexesⅠ,Ⅱ,and Ⅳ followed by increased superoxide anion generation.Moreover,As(V) triggers an apoptotic mode of cell death,demonstrated by an apoptotic SubG1 peak,associated with an alteration of plasma membrane integrity.There is also a decrease in transmembrane mitochondrial potential and mitochondrial adenosine triphosphate ATP.It is therefore tempting to speculate that As(V) triggers mitochondrial dysfunction,which may lead to defective oxidative phosphorylation subsequently causing mitochondrial oxidative damage,which in turn induces an apoptotic mode of cell death. | Wafa Kharroubi Samia Hai Ahmed Thomas Nury Pierre Andreoletti Rachid Sakly Mohamed Hammami Gerard Lizard | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 2 | Differential Alterations of Lipid Status and Lipid Metabolism, Induction of Oxidative Stress by Sodium Arsenate in Female Rat's Liver and Kidney显示文摘Three groups of female rats(n=6 per group) were exposed to 1 and 10 mg/L of sodium arsenate for 90 days. The antioxidant and peroxidation parameters in kidney and liver tissues were evaluated, also the fatty acid composition were determined. In liver the synthesis pathway of n-3 polyunsaturated fatty acids(PUFA) seemed to be more affected than the n-6 PUFA, while in kidney the n-6 pathway was more affected. The Δ5 ‘desaturase index' was decreased in kidney. Both in liver and kidney an increase in the percentage of trans PUFA was observed, also we noted a disturbance in antioxidant parameters as SOD, GPx, CAT, and GSH(P<0.05). While the protein carbonyl levels increased only in liver. | Kharroubi Wafa Dhibi Madiha Chreif Imed Gérard Lizard Hammami Mohamed Sakly Rachid | 2015 | Biomedical and Environmental Sciences2015，28，11： | 2 |
| 3 | Introduction of apoptosis and of interleukin-1 beta secretion by 7-beta-hydroxycholesterol and 7-ketocholesterol: Partial inhibition by bcl-2 overexpression 显示文摘 | Lizard G Lemire S Monier S | 1997 | FEBS Lett1997，419，： | 1 |
| 4 | Adhesion molecules (ICAM- 1 and VCAM-1) and diabetic retinopathy in type 2 diabetes显示文摘 | Taoufik Khalfaoui Ge'rard Lizard Amel Ouertani-Meddeb | 2008 | J Mol Hist2008，39，： | 1 |
| 5 | Glutathione is implied in file control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production显示文摘 | Lizard G Gueldry S Sordet D | 1998 | FASEB J1998，12，15： | 1 |
| 6 | Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: Preliminary study显示文摘 | T. Khalfaoui G. Lizard O. Beltaief D. Colin J. Ben Hamida K. Errais I. Ammous W. Zbiba L. Tounsi R. Zhioua R. Anane A. Ouertani-Meddeb | 2008 | Pathologie Biologie2008，，7： | 1 |
| 7 | Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associ- ated with radical oxygen species production显示文摘 | Lizard G Gueldry S Sordet O | 1998 | FASEB J1998，12，15： | 1 |
| 8 | Introduction of apoptosis and of interleukin-1 beta secretion by 7-beta-hydroxycholesterol and 7- ketocholesterol Partial inhibition by bcl-2 overexpression 显示文摘 | Lizard G Lemire S Monler S | 1997 | FEBS Lett1997，419，： | 1 |
| 9 | Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type?2 diabetes显示文摘 | Taoufik Khalfaoui Gérard Lizard Amel Ouertani-Meddeb | 2008 | Journal of Molecular Histology2008，，2： | 1 |
| 10 | Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or onco- sis), oxidative and inflammatory activities, and phospholipidosis 显示文摘 | Vejux A Lizard G | 2009 | Mol Aspects Med2009，30，3： | 1 |
| 11 | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall 显示文摘 | Lizard G Monier S Cordelet C | 1999 | Arterioscler Thromb Vasc Biol1999，19，5： | 1 |
| 12 | Glutathione is implied in the control of 7 - ketocholesterol induced apoptosis, which is associated with radical oxygen species production显示文摘 | Lizard G Gueldry S Sordet D | 1998 | FASEB J1998，12，15： | 1 |
| 13 | Kinetics of plasma membrane and mitochondrial alterations in cells undergoing apoptosis显示文摘 | Lizard G Fournel S Genestier L | 1995 | Cytometry1995，21，： | 1 |
| 14 | Cell surface expression of LDL receptor is decreased in type 2 diabetic patients and is normalized by insulin therapy显示文摘 | Laurenced Duvillard Emmanuel Florentin G′erard Lizard Jean-Michel Pettt Franc OiseGalland | 2003 | Diabetescare2003，26，5： | 1 |
| 15 | Predictive value of survivin alternative transcript expression in locally advanced breast cancer patients treated with neoadjuvant chemotherapy显示文摘 | Boidot R Vegran F Lizard Naeol S | 2009 | Int J Mol Med2009，23，2： | 1 |
| 16 | In situ hy- bridization detection of single-copy human papillomavirus on isolated cells,using a catalyzed signal amplification system: Gen Point显示文摘 | Lizard G Demares-Poulet MJ Roignot P | 2001 | Diagn Cytopathol2001，24，2： | 1 |
| 17 | Effects of resveratrol analogs on cell cycle progression,cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells显示文摘 | Colin D Gimazane A Lizard G | | 0，，： | 1 |
| 18 | Potential roles of peroxisomes in Alzheimer’s disease and in dementia of the Alzheimer’s type显示文摘 | LIZARD G ROUAUD O DEMARQUOY J | 2012 | Journal of Alzheimers Disease2012，29，2： | 1 |
| 19 | A simple and sensitive assay for 1-aminocy-clopropane-1-carbroxylic acid显示文摘 | Lizard MCC Yang SF | 1979 | Anal Biochem1979，100，： | 1 |
| 20 | Comparative evaluation of the antiproliferative effect of eyclosporin A and γ-interferon on normal and HPV-transformed keratinoeytes by cell counting, MTT assay and tritiated thymidine incorporation显示文摘 | MARIONNET A V LIZARD G CHARDONNET Y | 1997 | Cell Biology and Toxicology1997，13，2： | 1 |
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