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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | Trade policy and the Third World metropolis显示文摘 | Paul Krugman Raul Livas Elizondo | 1996 | Journal of Development Economics1996，，1： | 3 |
| 3 | Gastric autoimmune disorders in patients with chronic hepatitis C before,during and after interferon-alpha therapy显示文摘AIM: To explore the prevalence of autoimmune gastritis in chronic hepatitis C virus (HCV) patients and the influence of α-intefferon (IFN) treatment on autoimmune gastritis.METHODS: We performed a prospective study on 189patients with positive anti-HCV and viral RNA enrolled in a 12-month IFN protocol. We evaluated: a) the baseline prevalence of autoimmune gastritis, b) the impact of IFN treatment on development of biochemical signs of autoimmune gastritis (at 3, 6 and 12 months), c) the evolution after IFN withdrawal (12 months) in terms of anti-gastric-parietal-cell antibodies (APCA), gastrin, anti-thyroid, and anti-non-organ-specific antibodies.RESULTS: APCA positivity and 3-fold gastrin levels were detected in 3 (1.6 %) and 9 (5 %) patients, respectively, at baseline, in 25 (13 %) and 31 (16 %) patients at the end of treatment (both P<0.001, vs baseline), and in 7 (4 %) and 14 (7 %) patients 12 months after withdrawal (P=0.002and ,P=0.01 respectively, vs baseline; P=not significant vs end of treatment). The development of autoimmune gastritis was strictly associated with the presence of autoimmune thyroiditis (P =0.0001), no relationship was found with other markers of autoimmunity.CONCLUSION: In HCV patients, IFN frequently precipitates latent autoimmune gastritis, particularly in females. Following our 12-month protocol, the phenomenon generally regressed. Since APCA positivity and high gastrin levels are associated with the presence of antithyroid antibodies,development of autoimmune thyroiditis during IFN treatment may provide a surrogate preliminary indicator of possible autoimmune gastritis to limit the need for invasive examinations. | Carlo Fabbri M.Francesca Jaboli Silvia Giovanelli Francesco Azzaroli Alessandro Pezzoli Esterita Accogli Stefania Liva Giovanni Nigro Anna Miracolo Davide Festi Antonio Colecchia Marco Montagnani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 3 |
| 4 | Graph-based analysis and optimization of conten-tion resolution diversity slotted ALOHA显示文摘 | LIVA G | 2011 | IEEE Trans-actions on Communications2011，59，2： | 1 |
| 5 | Estriol ameliorate sauto immune demyelinating disease implication formultiple sclerosis 显示文摘 | Kim S Liva S M Dalai MA et ai | 1999 | Neurology1999，52，： | 1 |
| 6 | Facts and myths regarding the maxillary midline frenum and its treatment: a systematic review of the literature 显示文摘 | Delli K Livas C Sculean A | 2013 | Quintessence Int2013，44，2： | 1 |
| 7 | Quasi-cyclic general ized LDPC codes with low error floors显示文摘 | Liva G Ryan W E Chiani M | 2008 | IEEE Transactions on Communications2008，56，1： | 1 |
| 8 | Focused ultrasound and molecularly imprinted polymers: A new approach to organotin analysis in environmental samples显示文摘 | GALLEGO-GALLEGOS M LIVA M MUNOZ O R | 2006 | Journal of Chromatography A2006，1114，： | 1 |
| 9 | Maxillary sinus floor extension and posterior tooth inclination in adolescent patients with Class II division 1 malocclusion treated with maxillary first molar extractions显示文摘 | Livas C Halazonetis DJ Booij JW | 2013 | Am J Orthod Dentofacial Orthop2013，143，4： | 1 |
| 10 | Estriol ameliorates autoimmune demyelihating disease: Implications for multiple sclerosis injury显示文摘 | Kim S Liva S Dalai M | 1999 | Neurology1999，52，6： | 1 |
| 11 | Quantification of white spot lesions around orthodontic brackets with image analysis显示文摘 | Livas C Kuijpers-Jagtman AM Bronkhorst E | 2008 | Angle Orthod2008，78，4： | 1 |
| 12 | Induction of P-selectin by oxidized lipoproteins:Separats effects of synthesis and surface expression显示文摘 | Vora DK Fang TZ Liva SM | 1997 | Circ Res1997，80，： | 1 |
| 13 | Tumor necrosis factor-alpha regulation of the Id gene family in astrocytes and microglia during CNS inflammatory injury显示文摘 | Tzeng SF Kahn M Liva S | 1999 | Glia1999，26，2： | 1 |
| 14 | Short turbo codes over highorder fields显示文摘 | Liva G Paolini E Matuz B | 2013 | IEEE Trans on Communications2013，61，6： | 1 |
| 15 | Treatment of multiple sclerosis with the pregnancy hormone estriol显示文摘 | Sicotte NL Liva SM Klutch R | 2002 | Ann Neurol2002，52，4： | 1 |
| 16 | Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis显示文摘 | Kim S Liva SM Dalai M A | 1999 | Neurology1999，52，6： | 1 |
| 17 | Induction of P-selectin by oxidized lipoproteins: Separate effects of synthesis and surface expression 显示文摘 | Fang TZ Liva SM | 1997 | Circ Res1997，80，： | 1 |
| 18 | Trade Policy and the Third World Metropolis显示文摘 | Krugman P Livas R | 1996 | Journal of Development Economics1996，49，1： | 1 |
| 19 | Imaging of renovascular hypertension:respective Values of renal scintigraphy,renal Doppler U S,and M R angiography显示文摘 | Soulez G O liva VL Turpin S | 2000 | Radiographics2000，57，2： | 1 |
| 20 | Testosterone acts directly on CD4 + T lymphocytes to incrase IL-10 production显示文摘 | Liva SM Voskuhl RR | 2001 | J Immunol2001，167，4： | 1 |
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