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| 1 | Cosmogenic ^(10)Be dating of Guxiang and Baiyu Glaciations显示文摘Guxiang and Baiyu Glaciations are two previously recognized local glaciations of the Tibetan Plateau. They have been widely used as the reference standard for classifying Late Quaternary glaciations on the Tibetan Plateau and its surrounding mountains. However, the numerical chronologies of both glaciations have been lacking. In this study, cosmogenic 10Be dating was undertaken to define the timing of these two glaciations. The surface boulders deposited by the glaciers of the Guxiang and Baiyu Glaciations have exposure ages of 112.9±16.7―136.5±15.8 ka BP and 11.1±1.9―18.5±2.2 ka BP, respectively. It is likely that the Guxiang and Baiyu Glaciations correspond to marine isotope stages 6 and 2, respectively. | ZHOU ShangZhe XU LiuBing PATRICK M. Colgan DAVID M. Mickelson WANG XiaoLi WANG Jie ZHONG Wei | 2007 | Chinese Science Bulletin2007，52，10： | 28 |
| 2 | Novel Insights into Energy Storage Mechanism of Aqueous Rechargeable Zn/MnO2 Batteries with Participation of Mn2+显示文摘Aqueous rechargeable Zn/MnO2 zinc-ion batteries(ZIBs)are reviving recently due to their low cost,non-toxicity,and natural abundance.However,their energy storage mechanism remains controversial due to their complicated electrochemical reactions.Meanwhile,to achieve satisfactory cyclic stability and rate performance of the Zn/MnO2 ZIBs,Mn2+ is introduced in the electrolyte(e.g.,ZnSO4 solution),which leads to more complicated reactions inside the ZIBs systems.Herein,based on comprehensive analysis methods including electrochemical analysis and Pourbaix diagram,we provide novel insights into the energy storage mechanism of Zn/MnO2 batteries in the presence of Mn2+.A complex series of electrochemical reactions with the coparticipation of Zn2+,H+,Mn2+,SO42-,and OH-were revealed.During the first discharge process,co-insertion of Zn2+ and H+ promotes the transformation of MnO2 into ZnxMnO4,MnOOH,and Mn2O3,accompanying with increased electrolyte pH and the formation of ZnSO4·3 Zn(OH)2-5 H2O.During the subsequent charge process,ZnxMnO4,MnOOH,and Mn2O3 revert to a-MnO2 with the extraction of Zn2+ and H+,while ZnSO4·3Zn(OH)2·5H2O reacts with Mn2+ to form ZnMn3O7·3 H2O.In the following charge/discharge processes,besides aforementioned electrochemical reactions,Zn2+ reversibly insert into/extract from α-MnO2,ZnxMnO4,and ZnMn3O7·3H2O hosts;ZnSO4·3Zn(OH)2·5 H2O,Zn2Mn3O8,and ZnMn2O4 convert mutually with the participation of Mn2+.This work is believed to provide theoretical guidance for further research on high-performance ZIBs. | Yongfeng Huang Jian Mou Wenbao Liu Xianli Wang Liubing Dong Feiyu Kang Chengjun Xu | 2019 | Nano-Micro Letters2019，11，3： | 11 |
| 3 | Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties:preparation, characterization and application in a vaginal drug delivery system显示文摘Lack of mucoadhesive properties is the major drawback to poloxamer 407(F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an aminofunctionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407(F127-NH2) was synthesized and characterized with respect to its micellization behavior and interaction with mucin. Then using acetate gossypol(AG) as model drug, AG-loaded F127-NH2-based in situ hydrogels(NFGs) were evaluated with respect to rheology, drug release, ex vivo vaginal mucosal adhesion, in vivo intravaginal retention and local irritation after vaginal administration to healthy female mice. The results show that F127-NH2 is capable of forming a thermosensitive in situ hydrogel with sustained drug release properties. An interaction between positively charged F127-NH2 and negatively charged mucin wasrevealed by changes in the particle size and zeta potential of mucin particles as well as an increase in the complex modulus of NFG caused by mucin. Ex vivo and in vivo fluorescence imaging and quantitative analysis of the amount of AG remaining in mouse vaginal lavage all demonstrated greater intravaginal retention of NFG than that of an unmodified F127-based in situ hydrogel. In conclusion, amino group functionalization confers valuable mucoadhesive properties on poloxamer 407. | Liqian Ci Zhigang Huang Yu Liub Zhepeng Liu Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 11 |
| 4 | LiNbO3-coated LiNi0.8Co0.1Mn0.1O2 cathode with high discharge capacity and rate performance for all-solid-state lithium battery显示文摘In order to obtain high power density,energy density and safe energy storage lithium ion batteries(LIB)to meet growing demand for electronic products,oxide cathodes have been widely explored in all-solidstate lithium batteries(ASSLB)using sulfide solid electrolyte.However,the electrochemical performances are still not satisfactory,due to the high interfacial resistance caused by severe interfacial instability between sulfide solid electrolyte and oxide cathode,especially Ni-rich oxide cathodes,in charge-discharge process.Ni-rich LiNi0.8Co0.1Mn0.1O2(NCM811)material at present is one of the most key cathode candidates to achieve the high energy density up to 300 Wh kg^-1 in liquid LIB,but rarely investigated in ASSLB using sulfide electrolyte.To design the stable interface between NCM811 and sulfide electrolyte should be extremely necessary.In this work,in view of our previous work,LiNbO3 coating with about 1 wt% content is adopted to improve the interfacial stability and the electrochemical performances of NCM811 cathode in ASSLB using Li10GeP2S12 solid electrolyte.Consequently,LiNbO3-coated NCM811 cathode displays the higher discharge capacity and rate performance than the reported oxide electrodes in ASSLB using sulfide solid electrolyte to our knowledge. | Xuelei Li Liubing Jin Dawei Song Hongzhou Zhang Xixi Shi Zhenyu Wang Lianqi Zhang Lingyun Zhu | 2020 | Journal of Energy Chemistry2020，29，1： | 7 |
| 5 | A simple method for the isolation and purification of resveratrol from Polygonum cuspidatum显示文摘Resveratrol, a polyphenol compound with strong biological activity, has been widely used in medicine, health products and cosmetic industries. It is also the main active component of Polygonum cuspidatum, a well-known traditional Chinese medicine. We developed a simple and effective method for the preparation of resveratrol from P. cuspidatum. The whole preparative process consisted of reflux extraction, filtering, hydrolyzing, liquid-liquid extraction and eluting. Filtering is to remove non polar or less polar compounds and debris fragments from the extract. Hydrolyzing is to transform polydatin to resveratrol to improve the yield of resveratrol. Eluting is to remove impurities including strong acidic and water-soluble compounds. By acid hydrolysis of glycoside (polydatin), the yield of resveratrol increased about 4-fold. The extraction recovery in different stages was high, and the content of resveratrol in the final product was over 73.8%. Compared with other methods reported, this technology is eco-friendly, easier to perform, and also has a lower cost. | Dong-Geng Wanga Wen-Ying Liub Guang-Tong Chena | 2013 | Journal of Pharmaceutical Analysis2013，3，4： | 6 |
| 6 | High-Performance Aqueous Zinc-Ion Batteries Realized by MOF Materials显示文摘Rechargeable aqueous zinc-ion batteries(ZIB s) have been gaining increasing interest for large-scale energy storage applications due to their high safety,good rate capability,and low cost.However,the further development of ZIB s is impeded by two main challenges:Currently reported cathode materials usually suffer from rapid capacity fading or high toxicity,and meanwhile,unstable zinc stripping/plating on Zn anode seriously shortens the cycling life of ZIBs.In this paper,metal-organic framework(MOF) materials are proposed to simultaneously address these issues and realize high-performance ZIB s with Mn(BTC) MOF cathodes and ZIF-8-coated Zn(ZIF-8@Zn) anodes.Various MOF materials were synthesized,and Mn(BTC) MOF was found to exhibit the best Zn^2+-storage ability with a capacity of 112 mAh g^-1.Zn^2+ storage mechanism of the Mn(BTC) was carefully studied.Besides,ZIF-8@Zn anodes were prepared by coating ZIF-8 MOF material on Zn foils.Unique porous structure of the ZIF-8 coating guided uniform Zn stripping/plating on the surface of Zn anodes.As a result,the ZIF-8@Zn anodes exhibited stable Zn stripping/plating behaviors,with 8 times longer cycle life than bare Zn foils.Based on the above,high-performance aqueous ZIBs were constructed using the Mn(BTC) cathodes and the ZIF-8@Zn anodes,which displayed an excellent long-cycling stability without obvious capacity fading after 900 charge/discharge cycles.This work provides a new opportunity for high-performance energy storage system. | Xuechao Pu Baozheng Jiang Xianli Wang Wenbao Liu Liubing Dong Feiyu Kang Chengjun Xu | 2020 | Nano-Micro Letters2020，12，11： | 5 |
| 7 | Influence of acupuncture with exercise training on learning and memory functions, as well as microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region, in a rat model of cerebral infarction显示文摘The present study was designed to determine microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region in a rat model of middle cerebral artery occlusion. The rats were treated with acupuncture at Baihui (GV 20), Qubin (GB 7), and Qianding (GV 21) points, in addition to exercise training. Results were compared with rats undergoing exercise training only. The Y-maze method and immunohistochemistry revealed decreased error frequency of passing through Y-maze, as well as significantly increased microtubule-associated protein-2 and synaptophysin expression, in the acupuncture with exercise training group compared with the model and exercise training groups after 5 weeks. Microtubule-associated protein-2 and synaptophysin expressions negatively correlated with error frequency of passing through the Y-maze. These results suggested that acupuncture combined with exercise training improved learning and memory functions in a rat model of cerebral infarction. The mechanisms of action were hypothesized to be associated with dendritic or synaptic plasticity in the ipsilateral hippocampal CA3 region. | Wei Jiang Liubing Li Min Yang Yanzhen Bi Kehui Hu Peng Zhang Yixin Shen Qian Yu | 2011 | Neural Regeneration Research2011，6，27： | 4 |
| 8 | Simultaneously Regulating Uniform Zn^(2+) Flux and Electron Conduction by MOF/rGO Interlayers for High‑Performance Zn Anodes显示文摘Owing to the merits of low cost,high safety and environmental benignity,rechargeable aqueous Zn-based batteries(ZBs)have gained tremendous attention in recent years.Nevertheless,the poor reversibility of Zn anodes that originates from dendrite growth,surface passivation and corrosion,severely hinders the further development of ZBs.To tackle these issues,here we report a Janus separator based on a Zn-ion conductive metal-organic framework(MOF)and reduced graphene oxide(rGO),which is able to regulate uniform Zn2+flux and electron conduction simultaneously during battery operation.Facilitated by the MOF/rGO bifunctional interlayers,the Zn anodes demonstrate stable plating/stripping behavior(over 500 h at 1 mA cm^(−2)),high Coulombic efficiency(99.2%at 2 mA cm^(−2) after 100 cycles)and reduced redox barrier.Moreover,it is also found that the Zn corrosion can be effectively retarded through diminishing the potential discrepancy on Zn surface.Such a separator engineering also saliently promotes the overall performance of Zn|MnO2 full cells,which deliver nearly 100%capacity retention after 2000 cycles at 4 A g^(−1) and high power density over 10 kW kg^(−1).This work provides a feasible route to the high-performance Zn anodes for ZBs. | Ziqi Wang Liubing Dong Weiyuan Huang Hao Jia Qinghe Zhao Yidi Wang Bin Fei Feng Pan | 2021 | Nano-Micro Letters2021，13，5： | 3 |
| 9 | A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery显示文摘SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far.Due to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined in the biosafety level 3(BSL3)laboratory but this would hinder the basic research and antiviral drug development of SARS-CoV-2 because the BSL3 facility is not commonly available and the work in the containment is costly and laborious.In this study,we constructed a reverse genetics system of SARS-CoV-2 by assembling the viral cDNA in a bacterial artificial chromosome(BAC)vector with deletion of the spike(S)gene.Transfection of the cDNA into cells results in the production of an RNA replicon that keeps the capability of genome or subgenome replication but is deficient in virion assembly and infection due to the absence of S protein.Therefore,such a replicon system is not infectious and can be used in ordinary biological laboratories.We confirmed the efficient replication of the replicon by demonstrating the expression of the subgenomic RNAs which have similar profiles to the wild-type virus.By mutational analysis of nsp12 and nsp14,we showed that the RNA polymerase,exonuclease,and cap N7 methyltransferase play essential roles in genome replication and sgRNA production.We also created a SARS-CoV-2 replicon carrying a luciferase reporter gene and this system was validated by the inhibition assays with known anti-SARS-CoV-2 inhibitors.Thus,such a one-plasmid system is biosafe and convenient to use,which will benefit both fundamental research and development of antiviral drugs. | Yun-Yun Jin Hanwen Lin Liu Cao Wei-Chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing Fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo | 2021 | Virologica Sinica2021，36，5： | 2 |
| 10 | Printable Zinc‑Ion Hybrid Micro‑Capacitors for Flexible Self‑Powered Integrated Units显示文摘Wearable self-powered systems integrated with energy conversion and storage devices such as solar-charging power units arouse widespread concerns in scientific and industrial realms.However,their applications are hampered by the restrictions of unbefitting size matching between integrated modules,limited tolerance to the variation of input current,reliability,and safety issues.Herein,flexible solar-charging self-powered units based on printed Zn-ion hybrid micro-capacitor as the energy storage module is developed.Unique 3D micro-/nano-architecture of the biomass kelp-carbon combined with multivalent ion(Zn2+)storage endows the aqueous Zn-ion hybrid capacitor with high specific capacity(196.7 mAh g^−1 at 0.1 A g^−1).By employing an in-plane asymmetric printing technique,the fabricated quasi-solid-state Zn-ion hybrid microcapacitors exhibit high rate,long life and energy density up to 8.2μWh cm^−2.After integrating the micro-capacitor with organic solar cells,the derived self-powered system presents outstanding energy conversion/storage efficiency(ηoverall=17.8%),solar-charging cyclic stability(95%after 100 cycles),wide current tolerance,and good mechanical flexibility.Such portable,wearable,and green integrated units offer new insights into design of advanced self-powered systems toward the goal of developing highly safe,economic,stable,and long-life smart wearable electronics. | Juan Zeng Liubing Dong Lulu Sun Wen Wang Yinhua Zhou Lu Wei Xin Guo | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 11 | Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay显示文摘Plasma quinolone concentrations are not routinely measured in clinical practice.However,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients.In this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate method.After the assay procedure was optimized,the standard curve of sparfloxacin was established.The practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/mL.The recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,respectively.To demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin. | Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 12 | BOUNDARY VALUE PROBLEM FOR A GENERALIZED LINARD EQUATION显示文摘By coincidence degree,the existence of solution to the boundary value problem of a generalized Liénard equationa(t)x'+F(x,x′)x′+g(x)=e(t), x(0)=x(2π),x′(0)=x′(2π)is proved,where a∈C 1[0,2π],a(t)>0(0≤t≤2π),a(0)=a(2π),F(x,y)=f(x)+α|y| β,α>0,β>0 are all constants,f∈C(R,R),e∈C[0,2π]. An example is given as an application. | LiuBing YuJianshe | 2002 | Applied Mathematics(A Journal of Chinese Universities)2002，17，1： | 2 |
| 13 | Towards High-Energy and Anti-Self-Discharge Zn-Ion Hybrid Supercapacitors with New Understanding of the Electrochemistry显示文摘Aqueous Zn-ion hybrid supercapacitors(ZHSs)are increasingly being studied as a novel electrochemical energy storage system with prominent electrochemical performance,high safety and low cost.Herein,high-energy and anti-self-discharge ZHSs are realized based on the fibrous carbon cathodes with hierarchically porous surface and O/N heteroatom functional groups.Hierarchically porous surface of the fabricated free-standing fibrous carbon cathodes not only provides abundant active sites for divalent ion storage,but also optimizes ion transport kinetics.Consequently,the cathodes show a high gravimetric capacity of 156 mAh g^(−1),superior rate capability(79 mAh g^(−1)with a very short charge/discharge time of 14 s)and exceptional cycling stability.Meanwhile,hierarchical pore structure and suitable surface functional groups of the cathodes endow ZHSs with a high energy density of 127 Wh kg−1,a high power density of 15.3 kW kg^(−1)and good anti-self-discharge performance.Mechanism investigation reveals that ZHS electrochemistry involves cation adsorption/desorption and Zn_(4)SO_(4)(OH)_(6)·5H_(2)O formation/dissolution at low voltage and anion adsorption/desorption at high voltage on carbon cathodes.The roles of these reactions in energy storage of ZHSs are elucidated.This work not only paves a way for high-performance cathode materials of ZHSs,but also provides a deeper understanding of ZHS electrochemistry. | Yang Li Wang Yang Wu Yang Ziqi Wang Jianhua Rong Guoxiu Wang Chengjun Xu Feiyu Kang Liubing Dong | 2021 | Nano-Micro Letters2021，13，6： | 2 |
| 14 | The sedimentary source, planform stability and shore normal morphological change of the Xichong beach on the southern coast of the Dapeng Peninsula of Shenzhen, Guangdong Province, China显示文摘The coast of the Dapeng Peninsula has been honored as one of 'the eight most beautiful coasts in China'. The most precious tourism resource for the peninsula is headland bay beaches, among which the beach at Xichong on the southern coast of the peninsula is the longest and the most important one. The information of the stability, sedimentary source and shape change of the beach is very important for maintaining the beach in terms of sustainable development of the peninsula. Heavy minerals in the sand of the beach and the inland stream at Xichong are compared with those of a nearby beach on the same coast to determine the beach sand source; with help of a computer software, MEPBAY, the equilibrium planforms of the beaches on the peninsula are compared with those of an island without rivers to evaluate the stream's effects on the beach stability; cross shore profiles along the Xichong beach are also surveyed in different seasons of a year to assess the annual shore normal beach changes affected by the stream input, and the relation between the equilibrium planform state and cross shore changes of the beach. It is shown that(1) stream is the main sedimentary source of the beach and the weathering materials of the rocky headlands on both sides of the bay transported by waves are the second source for the beach but it is limited, sand from an inner shelf is not the sedimentary source for the beach at present and was not even during the Holocene transgression;(2) the Xichong beach cannot reach static equilibrium around the entire bay shoreline, the segment of the shoreline where a stream outlet is located is in dynamic equilibrium, and the unstable section occurs in the wave shadow region in the lee of an offshore island;(3) no matter whether the section of the beach shoreline at Xichong is in an equilibrium state or not, it is eroded in the typhoon season and recovered after the season, the maximum change in erosion and accretion occurs in the unstable segment;(4) the Xichong beach can only have small sand body since it is supplied with sand mainly form inland streams, resulting in a possible danger in which sand loss induced by human activities or huge storms cannot be replenished naturally. | ZHANG Song WANG Wei HUANG Rihui XU Liubing | 2015 | Acta Oceanologica Sinica2015，34，3： | 2 |
| 15 | HMSHzmutationsinhereditarynonpolyposiscolorectalcancerkindreds显示文摘 | LiuB ParsonsRE HamiltonSR etal | 1994 | CaneerRes1994，54，17： | 1 |
| 16 | MappingChina’ s mangroves based on an object-oriented classification of Landsatimagery显示文摘 | JIAM WANGZ LIL SONGK RENC LIUB MAO D | 2013 | Wetlands2013，34，2： | 1 |
| 17 | Research on Data Transmission Based on CC2530 of ZigBee显示文摘 | Linlin Cuia Yude Liub Wentian Shi Quan Gan Qi Liu | 2010 | 4th International Conference on Intelligent Information Technology Application:92-942010，4，： | 1 |
| 18 | Synthesisandcharacterizationofsinglecrystalα-Fe2O3 nanobelts显示文摘 | Wang H Z ZhangX T LiuB etal | 2006 | ChemistryLetters2006，35，1： | 1 |
| 19 | The dynamic effects of government-supported R&D subsidies:An empirical study on the Taiwan science park显示文摘 | Kuang-Hsien Wanga Jin-Long Liub | | 0，，1： | 1 |
| 20 | Collaboration diversity technology in wireless mobile communication显示文摘 | Liubing | | 0，，02： | 1 |
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