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| 1 | Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer’s disease显示文摘Gene therapy represents a promising treatment for the Alzheimer’s disease(AD). However,gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able to be specifically delivered to the amyloid plaques through surface modification with both CGN peptide for the blood–brain barrier(BBB)penetration and QSH peptide for β-amyloid binding. But, whether the as-designed nanocomplex could indeed improve the gene accumulation in the impaired neuron cells and ameliorate AD-associated symptoms remains further study. Herein, we prepared the nanocomplexes with an siRNA against β-site amyloid precursor protein-cleaving enzyme 1(BACE1), the rate-limiting enzyme of Aβ production, as the therapeutic siRNA of AD. The nanocomplexes exhibited high distribution in the Aβ deposits-enriched hippocampus, especially in the neurons near the amyloid plaques after intravenous administration. In APP/PS1 transgenic mice, the nanocomplexes down-regulated BACE1 in both mRNA and protein levels,as well as Aβ and amyloid plaques to the level of wild-type mice. Moreover, the nanocomplexes significantly increased the level of synaptophysin and rescued memory loss of the AD transgenic mice without hematological or histological toxicity. Taken together, this work presented direct evidences that the design of precise gene delivery to the AD lesions markedly improves the therapeutic outcome. | Qian Guo Xiaoyao Zheng Peng Yang Xiaoying Pang Kang Qian Pengzhen Wang Shuting Xu Dongyu Sheng Liuchang Wang Jinxu Cao Wei Lu Qizhi Zhang Xinguo Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 2 | SARS epidemical forecast research in mathematical model显示文摘The SIJR model, simplified from the SEIJR model, is adopted to analyze the important parameters of the model of SARS epidemic such as the transmission rate, basic reproductive number. And some important parameters are obtained such as the transmission rate by applying this model to analyzing the situation in Hong Kong, Singapore and Canada at the outbreak of SARS. Then forecast of the transmission of SARS is drawn out here by the adjustment of parameters (such as quarantined rate) in the model. It is obvious that inflexion lies on the crunode of the graph, which indicates the big difference in transmission characteristics between the epidemic under control and not under control. This model can also be used in the comparison of the control effectiveness among different regions. The results from this model match well with the actual data in Hong Kong, Singa- pore and Canada and as a by-product, the index of the effec- tiveness of control in the later period can be acquired. It of- fers some quantitative indexes, which may help the further research in epidemic diseases. | DINGGuanghong LIUChang GONGJianqiu WANGLing CHENGKe ZHANGDi | 2004 | Chinese Science Bulletin2004，49，21： | 2 |
| 3 | The hypoliPidemie and antioxidative effects of Pu-erh tea显示文摘 | Lin L C Liuchang H C Hwang L S | 1998 | Atheroselerosis1998，56，1： | 1 |
| 4 | 显示文摘 | FuHengzhi(傅恒志) LiXinzhong(李新中) LiuChang(刘畅)etal | 2005 | 中国有色金属学报2005，15，： | 1 |
| 5 | The hypolipidemic and antioxidative effects of pu-erh tea显示文摘 | Lin L C Liuchang H C Hwang L S | | Atherosclerosis0，136，1： | 1 |
| 6 | Advancedmaterialsforenergystorage显示文摘 | LiuChang LiFeng MaLaipeng etal | 2010 | AdvancedMaterials2010，22，8： | 1 |
| 7 | The hypolipidemic and antioxidative effects of pu-erh tea 显示文摘 | LAN-CHI LIN HUEI-CHIUAN LIUCHANG LUCY SUN HWANG | 1998 | Atherosclerosis1998，136，： | 1 |
| 8 | Unsafe care cardiovascular department of internal medicine analysis 显示文摘 | Zhou Liuchang | 2010 | China herald of medicine2010，25，16： | 1 |
| 9 | 显示文摘 | LIUChang HONGHan-lie YINKe etal(刘畅 洪汉烈 殷科 等) | 2012 | 宝石和宝石学杂志2012，14，2： | 1 |
| 10 | StudiesonthePollenMorphologyandPollenGerminationMorpholo-gyinGrapecultivars[J]显示文摘 | LIUChang′ell(刘长恩) ZHULin(朱林) | 1985 | 园艺学报1985，12，1： | 1 |
| 11 | The hypolipidemic and antioxidative effects of pu-erh tea显示文摘 | Lan-Chi Lin Huei-Chiuan Liuchang Lucy Sun Hwang | 1998 | Atherosclerosis1998，136，1： | 1 |
| 12 | The hypolipidemic and antioxidative effects of pu-erh tea显示文摘 | Lan-Chi Lin Huei-Chiuan Liuchang Lucy Sun Hwang et al | 1998 | Atherosclerosis[J]1998，136，1： | 1 |
| 13 | The hypolipidemic and antioxidafive effects of pu-erh tea显示文摘 | LIN L C LIUCHANG H C HWANG L S | 1998 | Atherosclerosis1998，136，1： | 1 |
| 14 | The design and fabrication on gate type resonant tunneling transistor显示文摘In light of fabricating resonant tunneling diode(RTD),in this paper a GaAs-based resonant tunneling transistor with gate structure(GRTT)has been designed and fabricated successfully.A systematic depiction centers on the designs of material structure,device structure,photo-lithography mask,fabrication of device and the measurement and analysis of parameters.The fabricated GRTT has a maximum PVCR of 46 and a maximum transconductance of 8 mS.The work lays the foundation for further improve-ment on the performance and parameters of RTT. | Weilian GUO Huilai LIANG Ruiliang SONG Shilin ZHANG Luhong MAO Liuchang HU Jianheng LI Haitao QI Zhen FENG Guoping TIAN Yuehui SHANG Yongqiang LIU Yali LI Mingwen YUAN Xiaobai LI | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，2： | 0 |
| 15 | Preparation and luminescent properties of CaF_2:Ln^(3+)(Ln:Er, Er/Yb)/Nafion composite films显示文摘In this work, CaF_2:Ln^(3+)(Ln:Er,Er/Yb)/Nafion composite films were prepared using Nafion as modifications and matrices by dripping method. The composite films were characterized by Fourier transform infrared spectroscopy(FT-IR), X-ray diffraction(XRD) and scanning electron microscopy(SEM). Composite films are transparent and CaF_2:Ln^(3+)(Ln:Er,Er/Yb) nanoparticles are well dispersed in Nafion films.The thicknesses of CaF_2:Er^(3+)/Nafion and CaF_2:Er^(3+),Yb^(3+)/Nafion composite film are about 77 and 73 μm,respectively. The nanoparticles in composite film possess cubic phase. CaF_2:Er^(3+),Yb^(3+)/Nafion composite film has stronger characteristic emission of Er^(3+) around 1530 nm with full width at half-maximum(FWHM) of 73 nm and longer luminescence lifetimes of 22.04 μs(25.03%) and 100.77 μs(74.97%). | Limei Song Jianhua Gao Minmin Liang Xiaojun Li Jiangtao Li Liuchang Wang | 2019 | Journal of Rare Earths2019，37，3： | 0 |
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